Detail Information

Basic Information:


  VIRBase ID:  

HHID00010403

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           ABCF2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p ABCF2
miRBase
Accession/Entrez ID		 MIMAT0004588 10061
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ABC28//EST133090//HUSSY-18//HUSSY18

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ABCF2
chr7:150913842(-) A-I      intronic
chr7:150917996(-) A-I      intronic
chr7:150913795(-) A-I      intronic
chr7:150913827(-) A-I      intronic
chr7:150917063(-) A-I      intronic
chr7:150917974(-) A-I      intronic
chr7:150914665(-) A-I      intronic
chr7:150917882(-) A-I      intronic
chr7:150918434(-) A-I      intronic
chr7:150918489(-) A-I      intronic
chr7:150913873(-) A-I      intronic
chr7:150917997(-) A-I      intronic
chr7:150908258(-) A-I      intronic
chr7:150913766(-) A-I      intronic
chr7:150913693(-) A-I      intronic
chr7:150917979(-) A-I      intronic
chr7:150914767(-) A-I      intronic
chr7:150914722(-) A-I      intronic
chr7:150913794(-) A-I      intronic
chr7:150917829(-) A-I      intronic
chr7:150914839(-) A-I      intronic
chr7:150914630(-) A-I      intronic
chr7:150917987(-) A-I      intronic
chr7:150913813(-) A-I      intronic
chr7:150913687(-) A-I      intronic
chr7:150913846(-) A-I      intronic
chr7:150914827(-) A-I      intronic
chr7:150914719(-) A-I      intronic
chr7:150914757(-) A-I      intronic
chr7:150917926(-) A-I      intronic
chr7:150914693(-) A-I      intronic
chr7:150913769(-) A-I      intronic
chr7:150914628(-) A-I      intronic
chr7:150917073(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ABCF2
chr7:150913760(-) A-G intron -    22484847
chr7:150913846(-) A-G intron -    22484847
chr7:150913879(-) A-G intron -    22484847
chr7:150914827(-) A-G intron -    22484847
chr7:150914838(-) T-G intron -    22484847
chr7:150917073(-) A-G intron -    22484847
chr7:150917839(-) A-G intron -    22484847
chr7:150917857(-) A-G intron -    22484847
chr7:150917979(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ABCF2
chr7:150909612-150909613(-) m6A 3'UTR//intron       24981863//22608085
chr7:150909618-150909619(-) m6A 3'UTR//intron       24981863//22608085
chr7:150909739-150909740(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:150909769-150909770(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:150909792-150909793(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr7:150909889-150909890(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22608085
chr7:150909911-150909912(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr7:150910042-150910043(-) m6A 3'UTR//intron       24284625//24209618
chr7:150910052-150910053(-) m6A 3'UTR//intron       24284625
chr7:150910065-150910066(-) m6A 3'UTR//intron       24284625
chr7:150910234-150910235(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr7:150910246-150910247(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr7:150910306-150910307(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr7:150910399-150910400(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr7:150910458-150910459(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:150910481-150910482(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:150910488-150910489(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:150910640-150910641(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:150910691-150910692(-) m6A 3'UTR//intron       27773535
chr7:150910697-150910698(-) m6A 3'UTR//intron       27773535
chr7:150910910-150910911(-) m6A 3'UTR//intron       24284625//24209618//24981863//22575960
chr7:150910963-150910964(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chr7:150911061-150911062(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr7:150911066-150911067(-) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr7:150911099-150911100(-) m6A 3'UTR//intron       24284625//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr7:150911153-150911154(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr7:150911221-150911222(-) m6A CDS       24284625//27773536//22575960//22608085
chr7:150911243-150911244(-) m6A CDS       22575960
chr7:150913085-150913086(-) m6A CDS       24284625
chr7:150915866-150915867(-) m6A CDS//exon       27371828//27773536
chr7:150916198-150916199(-) m6A CDS//exon       27773535
chr7:150918678-150918679(-) m6A CDS//exon       27773535
chr7:150918878-150918879(-) m6A exon//intron       27773535
chr7:150919614-150919615(-) m6A CDS       24284625
chr7:150919645-150919646(-) m6A CDS       24284625//25456834
chr7:150920802-150920803(-) m6A CDS       24284625//25456834//24981863//27371828//22575960
chr7:150920843-150920844(-) m6A CDS       24284625//25456834//24981863//27371828//22575960
chr7:150921098-150921099(-) m6A CDS       24284625//27371828//22575960
chr7:150922043-150922044(-) m6A CDS       24981863//27773535//27371828//27773536
chr7:150923396-150923397(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chr7:150923436-150923437(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chr7:150923466-150923467(-) m6A CDS       24284625//24981863//27773535//27371828//27773536//22575960
chr7:150923519-150923520(-) m1A CDS       26863196
chr7:150923575-150923576(-) m6A 5'UTR//exon       24284625//24981863//27773535//27371828//27773536//22575960
chr7:150923867-150923868(-) m6A exon//intron       24981863
chr7:150923886-150923887(-) m6A exon//intron       24981863
chr7:150923899-150923900(-) m6A exon//intron       25456834//24981863
chr7:150924058-150924059(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr7:150924069-150924070(-) m6A 5'UTR//intron       24284625//25456834//24981863
chr7:150924092-150924093(-) m6A 5'UTR//intron       24284625//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ABCF2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: ABCF2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...