Detail Information

Basic Information:


  VIRBase ID:  

HHID00010399

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           HS3ST3B1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p HS3ST3B1
miRBase
Accession/Entrez ID		 MIMAT0004588 9953
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 3-OST-3B//3OST3B1//h3-OST-3B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HS3ST3B1
chr17:14228277(+) A-I      intronic
chr17:14228290(+) A-I      intronic
chr17:14228296(+) A-I      intronic
chr17:14228295(+) A-I      intronic
chr17:14228297(+) A-I      intronic
chr17:14246373(+) A-I      intronic
chr17:14247340(+) A-I      intronic
chr17:14247343(+) A-I      intronic
chr17:14218890(+) A-I      intronic
chr17:14238805(+) A-I      intronic
chr17:14230159(+) A-I      intronic
chr17:14218954(+) A-I      intronic
chr17:14236529(+) A-I      intronic
chr17:14241816(+) A-I      intronic
chr17:14217377(+) A-I      intronic
chr17:14218963(+) A-I      intronic
chr17:14236637(+) A-I      intronic
chr17:14217376(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HS3ST3B1
chr17:14232451(+) A-I intron -    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HS3ST3B1
chr17:14204459-14204460(+) m6A 5'UTR       24981863
chr17:14204724-14204725(+) m6A 5'UTR       25456834
chr17:14204757-14204758(+) m6A 5'UTR       25456834//24981863
chr17:14204785-14204786(+) m6A 5'UTR       25456834//24981863
chr17:14205193-14205194(+) m6A CDS       25456834//24981863
chr17:14207180-14207181(+) m6A intron       25456834//24981863//22608085
chr17:14207205-14207206(+) m6A intron       25456834//24981863//22608085
chr17:14207220-14207221(+) m6A intron       25456834//24981863//22608085
chr17:14207225-14207226(+) m6A intron       25456834//24981863//22608085
chr17:14207378-14207379(+) m6A intron       25456834//24981863//22608085
chr17:14207402-14207403(+) m6A intron       25456834//24981863//22608085
chr17:14207478-14207479(+) m6A intron       25456834//24981863//22608085
chr17:14207553-14207554(+) m6A intron       25456834//22608085
chr17:14207566-14207567(+) m6A intron       25456834//22608085
chr17:14207659-14207660(+) m6A intron       25456834//24981863//22608085
chr17:14207674-14207675(+) m6A intron       25456834//22608085
chr17:14208099-14208100(+) m6A intron       22608085
chr17:14208123-14208124(+) m6A intron       22608085
chr17:14208143-14208144(+) m6A intron       22608085
chr17:14208507-14208508(+) m6A intron       25456834//24981863//22608085
chr17:14208595-14208596(+) m6A intron       25456834//24981863//22608085
chr17:14208604-14208605(+) m6A intron       25456834//24981863//22608085
chr17:14208616-14208617(+) m6A intron       25456834//24981863//22608085
chr17:14208651-14208652(+) m6A intron       25456834//24981863//22608085
chr17:14208698-14208699(+) m6A intron       25456834//22608085
chr17:14232560-14232561(+) m6A intron       27773535
chr17:14248727-14248728(+) m6A CDS       24981863
chr17:14248757-14248758(+) m6A CDS       24981863
chr17:14248780-14248781(+) m6A CDS       24981863//22608085
chr17:14248843-14248844(+) m6A CDS       25456834//24981863//22608085
chr17:14248855-14248856(+) m6A CDS       25456834//24981863//22608085
chr17:14248967-14248968(+) m6A 3'UTR       25456834//24981863//22608085
chr17:14251468-14251469(+) m6A 3'UTR       24981863//22608085
chr17:14251521-14251522(+) m6A 3'UTR       24981863//22608085
chr17:14251558-14251559(+) m6A 3'UTR       24981863//22608085
chr17:14251564-14251565(+) m6A 3'UTR       24981863//22608085
chr17:14251605-14251606(+) m6A 3'UTR       24981863//22608085
chr17:14252305-14252306(+) m6A 3'UTR       22608085
chr17:14252364-14252365(+) m6A 3'UTR       24981863//22608085
chr17:14252371-14252372(+) m6A 3'UTR       24981863//22608085
chr17:14252443-14252444(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
HS3ST3B1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: HS3ST3B1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...