Basic Information:

  VIRBase ID:  

HHID00010394

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          FAM20B:  NM_001324311     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	FAM20B
miRBase Accession/Entrez ID	MIMAT0004588	9917
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	gxk1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM20B	chr1:179044079(+) A-I      3'UTR chr1:179036539(+) A-I      intronic chr1:179044168(+) A-I      3'UTR chr1:179044167(+) A-I      3'UTR chr1:179036554(+) A-I      intronic chr1:179044173(+) A-I      3'UTR chr1:179036556(+) A-I      intronic chr1:179044142(+) A-I      3'UTR chr1:179036563(+) A-I      intronic chr1:179036564(+) A-I      intronic chr1:179044129(+) A-I      3'UTR chr1:179042575(+) A-I      3'UTR chr1:179044177(+) A-I      3'UTR chr1:179020511(+) A-I      intronic chr1:179031767(+) A-I      intronic chr1:179044229(+) A-I      3'UTR chr1:179044339(+) A-I      3'UTR chr1:179044188(+) A-I      3'UTR chr1:179042550(+) A-I      3'UTR chr1:179036680(+) A-I      intronic chr1:179044223(+) A-I      3'UTR chr1:179042667(+) A-I      3'UTR chr1:179042531(+) A-I      3'UTR chr1:179039857(+) A-I      intronic chr1:179007471(+) A-I      intronic chr1:179042494(+) A-I      3'UTR chr1:179006689(+) A-I      intronic chr1:179042631(+) A-I      3'UTR chr1:179042476(+) A-I      3'UTR chr1:179042612(+) A-I      3'UTR chr1:179042587(+) A-I      3'UTR chr1:179020703(+) A-I      intronic chr1:179020885(+) A-I      intronic chr1:179001508(+) A-I      intronic chr1:179044309(+) A-I      3'UTR chr1:179044292(+) A-I      3'UTR chr1:179042475(+) A-I      3'UTR chr1:179044277(+) A-I      3'UTR chr1:179044183(+) A-I      3'UTR chr1:179006651(+) A-I      intronic chr1:179038635(+) A-I      intronic chr1:179044174(+) A-I      3'UTR chr1:179044260(+) A-I      3'UTR chr1:179020002(+) A-I      intronic chr1:179037696(+) A-I      intronic chr1:179031271(+) A-I      intronic chr1:179019979(+) A-I      intronic chr1:179020559(+) A-I      intronic chr1:179020983(+) A-I      intronic chr1:179037055(+) A-I      intronic chr1:179020603(+) A-I      intronic chr1:179042568(+) A-I      3'UTR chr1:179001483(+) A-I      intronic chr1:179044248(+) A-I      3'UTR chr1:179044247(+) A-I      3'UTR chr1:179037028(+) A-I      intronic chr1:179038645(+) A-I      intronic chr1:179044118(+) A-I      3'UTR chr1:179044071(+) A-I      3'UTR chr1:179020861(+) A-I      intronic chr1:179042720(+) A-I      3'UTR chr1:179020095(+) A-I      intronic chr1:179020096(+) A-I      intronic chr1:179020966(+) A-I      intronic chr1:179042710(+) A-I      3'UTR chr1:179042673(+) A-I      3'UTR chr1:179020484(+) A-I      intronic chr1:179039378(+) A-I      intronic chr1:179020927(+) A-I      intronic chr1:179020092(+) A-I      intronic chr1:179015667(+) A-I      intronic chr1:179007280(+) A-I      intronic chr1:179015702(+) A-I      intronic chr1:179042544(+) A-I      3'UTR chr1:179031755(+) A-I      intronic chr1:179037044(+) A-I      intronic chr1:179020980(+) A-I      intronic chr1:179044252(+) A-I      3'UTR chr1:179005010(+) A-I      intronic chr1:179005009(+) A-I      intronic chr1:179042692(+) A-I      3'UTR chr1:179042555(+) A-I      3'UTR chr1:179020682(+) A-I      intronic chr1:179020840(+) A-I      intronic chr1:179037038(+) A-I      intronic chr1:179044212(+) A-I      3'UTR chr1:179042590(+) A-I      3'UTR chr1:179044181(+) A-I      3'UTR chr1:179037736(+) A-I      intronic chr1:179037003(+) A-I      intronic chr1:179036613(+) A-I      intronic chr1:179015621(+) A-I      intronic chr1:179007386(+) A-I      intronic chr1:179036632(+) A-I      intronic chr1:179036628(+) A-I      intronic chr1:179044233(+) A-I      3'UTR chr1:179042617(+) A-I      3'UTR chr1:179006896(+) A-I      intronic chr1:179044169(+) A-I      3'UTR chr1:179044216(+) A-I      3'UTR chr1:179044315(+) A-I      3'UTR chr1:179007368(+) A-I      intronic chr1:179030734(+) A-I      intronic chr1:179020583(+) A-I      intronic chr1:179042623(+) A-I      3'UTR chr1:179044096(+) A-I      3'UTR chr1:179020620(+) A-I      intronic chr1:179042719(+) A-I      3'UTR chr1:179042687(+) A-I      3'UTR chr1:179044180(+) A-I      3'UTR chr1:179044317(+) A-I      3'UTR chr1:179044206(+) A-I      3'UTR chr1:179020641(+) A-I      intronic chr1:179030571(+) A-I      intronic chr1:179020518(+) A-I      intronic chr1:179020639(+) A-I      intronic chr1:179015610(+) A-I      intronic chr1:179044329(+) A-I      3'UTR chr1:179044268(+) A-I      3'UTR chr1:179031267(+) A-I      intronic chr1:179039381(+) A-I      intronic chr1:179042551(+) A-I      3'UTR chr1:179044110(+) A-I      3'UTR chr1:179036584(+) A-I      intronic chr1:179037095(+) A-I      intronic chr1:179042482(+) A-I      3'UTR chr1:179007475(+) A-I      intronic chr1:179044196(+) A-I      3'UTR chr1:179042697(+) A-I      3'UTR chr1:179007496(+) A-I      intronic chr1:179020008(+) A-I      intronic chr1:179044092(+) A-I      3'UTR chr1:179039928(+) A-I      intronic chr1:179036587(+) A-I      intronic chr1:179014900(+) A-I      intronic chr1:179042732(+) A-I      3'UTR chr1:179031235(+) A-I      intronic chr1:179015693(+) A-I      intronic chr1:179036484(+) A-I      intronic chr1:179030307(+) A-I      intronic chr1:179018699(+) A-I      intronic chr1:179020882(+) A-I      intronic chr1:179044242(+) A-I      3'UTR chr1:179015676(+) A-I      intronic chr1:179044105(+) A-I      3'UTR chr1:179007536(+) A-I      intronic chr1:179042592(+) A-I      3'UTR chr1:179020957(+) A-I      intronic chr1:179044004(+) A-I      3'UTR chr1:179042905(+) A-I      3'UTR chr1:179007425(+) A-I      intronic chr1:179044272(+) A-I      3'UTR chr1:179044115(+) A-I      3'UTR chr1:179044297(+) A-I      3'UTR chr1:178997667(+) A-I      intronic chr1:179044100(+) A-I      3'UTR chr1:179036968(+) A-I      intronic chr1:179039224(+) A-I      intronic chr1:179044165(+) A-I      3'UTR chr1:179044239(+) A-I      3'UTR chr1:179042616(+) A-I      3'UTR chr1:179018938(+) A-I      intronic chr1:179020651(+) A-I      intronic chr1:179042512(+) A-I      3'UTR chr1:179039860(+) A-I      intronic chr1:179042701(+) A-I      3'UTR chr1:179020923(+) A-I      intronic chr1:179044255(+) A-I      3'UTR chr1:179044175(+) A-I      3'UTR chr1:179007382(+) A-I      intronic chr1:179043382(+) A-I      3'UTR chr1:179018951(+) A-I      intronic chr1:179018707(+) A-I      intronic chr1:179014898(+) A-I      intronic chr1:179036999(+) A-I      intronic chr1:179044076(+) A-I      3'UTR chr1:179007491(+) A-I      intronic chr1:179044279(+) A-I      3'UTR chr1:179031670(+) A-I      intronic chr1:179036651(+) A-I      intronic chr1:179021044(+) A-I      intronic chr1:179036609(+) A-I      intronic chr1:179042741(+) A-I      3'UTR chr1:179044166(+) A-I      3'UTR chr1:179036589(+) A-I      intronic chr1:178997464(+) A-I      intronic chr1:179044261(+) A-I      3'UTR chr1:179036462(+) A-I      intronic chr1:179044151(+) A-I      3'UTR chr1:179042580(+) A-I      3'UTR chr1:179037166(+) A-I      intronic chr1:179020967(+) A-I      intronic chr1:179031674(+) A-I      intronic chr1:179044176(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM20B	chr1:179042544(+) A-I exon 3'UTR    15342557 chr1:179042701(+) A-I exon 3'UTR    15342557   //22327324 chr1:179044100(+) A-I exon 3'UTR    15342557   //21960545 chr1:179044105(+) A-I exon 3'UTR    15342557 chr1:179044110(+) A-I exon 3'UTR    15342557   //22327324 chr1:179044180(+) A-I exon 3'UTR    15342557   //22327324 chr1:179044196(+) A-I exon 3'UTR    15342557 chr1:179044206(+) A-I exon 3'UTR    15342557   //22327324 chr1:179044216(+) A-I exon 3'UTR    15342557   //22327324 chr1:179044239(+) A-I exon 3'UTR    15342557 chr1:179044242(+) A-I exon 3'UTR    15342557 chr1:179044252(+) A-I exon 3'UTR    15342557   //22327324 chr1:179042482(+) A-I intron -    22327324 chr1:179042616(+) A-I intron -    22327324 chr1:179042905(+) A-I intron -    22327324 chr1:179044004(+) A-I intron -    22327324 chr1:179044092(+) A-I intron -    22327324 chr1:179044181(+) A-I intron -    22327324 chr1:179042667(+) A-I intron -    21960545 chr1:179042905(+) A-G intron -    21725310   //22484847 chr1:179018699(+) A-G intron -    22484847 chr1:179018707(+) A-G intron -    22484847 chr1:179018951(+) A-G intron -    22484847 chr1:179020008(+) A-G intron -    22484847 chr1:179020092(+) A-G intron -    22484847 chr1:179020518(+) A-G intron -    22484847 chr1:179020620(+) A-G intron -    22484847 chr1:179020840(+) A-G intron -    22484847 chr1:179020882(+) A-G intron -    22484847 chr1:179020923(+) A-G intron -    22484847 chr1:179020957(+) A-G intron -    22484847 chr1:179020967(+) A-G intron -    22484847 chr1:179020980(+) A-G intron -    22484847 chr1:179030585(+) G-A intron -    22484847 chr1:179036584(+) A-G intron -    22484847 chr1:179036589(+) A-G intron -    22484847 chr1:179037166(+) A-G intron -    22484847 chr1:179042482(+) A-G intron -    22484847 chr1:179042555(+) A-G intron -    22484847 chr1:179042580(+) A-G intron -    22484847 chr1:179042590(+) A-G intron -    22484847 chr1:179042616(+) A-G intron -    22484847 chr1:179042617(+) A-G intron -    22484847 chr1:179042697(+) A-G intron -    22484847 chr1:179042701(+) A-G intron -    22484847 chr1:179042719(+) A-G intron -    22484847 chr1:179044092(+) A-G intron -    22484847 chr1:179044096(+) A-G intron -    22484847 chr1:179044100(+) A-G intron -    22484847 chr1:179044105(+) A-G intron -    22484847 chr1:179044110(+) A-G intron -    22484847 chr1:179044175(+) A-G intron -    22484847 chr1:179044176(+) A-G intron -    22484847 chr1:179044180(+) A-G intron -    22484847 chr1:179044181(+) A-G intron -    22484847 chr1:179044196(+) A-G intron -    22484847 chr1:179044206(+) A-G intron -    22484847 chr1:179044212(+) A-G intron -    22484847 chr1:179044216(+) A-G intron -    22484847 chr1:179044242(+) A-G intron -    22484847 chr1:179044252(+) A-G intron -    22484847 chr1:179044279(+) A-G intron -    22484847 chr1:179044315(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM20B	chr1:179000263-179000264(+) Am intron       - chr1:179012851-179012852(+) m6A 5'UTR       24209618 chr1:179012881-179012882(+) m6A 5'UTR       24209618 chr1:179013091-179013092(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:179013151-179013152(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179013222-179013223(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr1:179013297-179013298(+) m6A CDS       24209618//24981863//22608085 chr1:179035942-179035943(+) m6A CDS       24284625 chr1:179041067-179041068(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr1:179041076-179041077(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr1:179041175-179041176(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041235-179041236(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:179041253-179041254(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:179041301-179041302(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:179041325-179041326(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:179041393-179041394(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041435-179041436(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041447-179041448(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041470-179041471(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041564-179041565(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr1:179041631-179041632(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041671-179041672(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041710-179041711(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:179041759-179041760(+) m6A 3'UTR       24284625//24209618//24981863 chr1:179041835-179041836(+) m6A 3'UTR       24209618//24981863 chr1:179041841-179041842(+) m6A 3'UTR       24209618//24981863 chr1:179041918-179041919(+) m6A 3'UTR       24209618//24981863 chr1:179041931-179041932(+) m6A 3'UTR       24981863 chr1:179041954-179041955(+) m6A 3'UTR       24981863//26404942 chr1:179041965-179041966(+) m6A 3'UTR       24981863//26404942 chr1:179042009-179042010(+) m6A 3'UTR       24981863 chr1:179042294-179042295(+) Gm 3'UTR       - chr1:179043647-179043648(+) m6A 3'UTR       24981863 chr1:179043654-179043655(+) m6A 3'UTR       24981863 chr1:179044125-179044126(+) m6A 3'UTR       24209618 chr1:179044152-179044153(+) m6A 3'UTR       24209618 chr1:179045026-179045027(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	FAM20B	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: FAM20B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).