Detail Information

Basic Information:


  VIRBase ID:  

HHID00010377

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           N4BP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p N4BP1
miRBase
Accession/Entrez ID		 MIMAT0004588 9683
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR N4BP1
chr16:48628556(-) A-I      intronic
chr16:48635651(-) A-I      intronic
chr16:48604949(-) A-I      intronic
chr16:48618603(-) A-I      intronic
chr16:48619880(-) A-I      intronic
chr16:48619896(-) A-I      intronic
chr16:48579692(-) A-I      intronic
chr16:48627710(-) A-I      intronic
chr16:48627789(-) A-I      intronic
chr16:48579937(-) A-I      intronic
chr16:48604840(-) A-I      intronic
chr16:48579674(-) A-I      intronic
chr16:48578972(-) A-I      intronic
chr16:48579389(-) A-I      intronic
chr16:48579402(-) A-I      intronic
chr16:48628534(-) A-I      intronic
chr16:48628430(-) A-I      intronic
chr16:48641984(-) A-I      intronic
chr16:48638244(-) A-I      intronic
chr16:48638243(-) A-I      intronic
chr16:48579013(-) A-I      intronic
chr16:48635859(-) A-I      intronic
chr16:48635714(-) A-I      intronic
chr16:48579045(-) A-I      intronic
chr16:48579122(-) A-I      intronic
chr16:48635673(-) A-I      intronic
chr16:48597171(-) A-I      intronic
chr16:48603346(-) A-I      intronic
chr16:48604422(-) A-I      intronic
chr16:48604506(-) A-I      intronic
chr16:48604507(-) A-I      intronic
chr16:48604818(-) A-I      intronic
chr16:48604819(-) A-I      intronic
chr16:48604896(-) A-I      intronic
chr16:48579143(-) A-I      intronic
chr16:48604906(-) A-I      intronic
chr16:48604916(-) A-I      intronic
chr16:48604934(-) A-I      intronic
chr16:48579359(-) A-I      intronic
chr16:48629138(-) A-I      intronic
chr16:48638205(-) A-I      intronic
chr16:48628509(-) A-I      intronic
chr16:48579259(-) A-I      intronic
chr16:48642187(-) A-I      intronic
chr16:48579069(-) A-I      intronic
chr16:48606812(-) A-I      intronic
chr16:48643122(-) A-I      intronic
chr16:48641901(-) A-I      intronic
chr16:48636782(-) A-I      intronic
chr16:48638407(-) A-I      intronic
chr16:48638342(-) A-I      intronic
chr16:48643074(-) A-I      intronic
chr16:48636799(-) A-I      intronic
chr16:48579426(-) A-I      intronic
chr16:48643043(-) A-I      intronic
chr16:48579450(-) A-I      intronic
chr16:48627718(-) A-I      intronic
chr16:48578930(-) A-I      intronic
chr16:48619382(-) A-I      intronic
chr16:48639040(-) A-I      intronic
chr16:48638217(-) A-I      intronic
chr16:48579365(-) A-I      intronic
chr16:48579771(-) A-I      intronic
chr16:48619376(-) A-I      intronic
chr16:48628351(-) A-I      intronic
chr16:48628403(-) A-I      intronic
chr16:48643004(-) A-I      intronic
chr16:48635746(-) A-I      intronic
chr16:48603431(-) A-I      intronic
chr16:48579745(-) A-I      intronic
chr16:48579079(-) A-I      intronic
chr16:48579481(-) A-I      intronic
chr16:48639214(-) A-I      intronic
chr16:48639012(-) A-I      intronic
chr16:48619844(-) A-I      intronic
chr16:48616945(-) A-I      intronic
chr16:48638352(-) A-I      intronic
chr16:48628386(-) A-I      intronic
chr16:48579293(-) A-I      intronic
chr16:48639082(-) A-I      intronic
chr16:48639011(-) A-I      intronic
chr16:48643031(-) A-I      intronic
chr16:48635883(-) A-I      intronic
chr16:48579488(-) A-I      intronic
chr16:48641869(-) A-I      intronic
chr16:48635875(-) A-I      intronic
chr16:48643010(-) A-I      intronic
chr16:48638264(-) A-I      intronic
chr16:48628363(-) A-I      intronic
chr16:48579148(-) A-I      intronic
chr16:48627813(-) A-I      intronic
chr16:48641905(-) A-I      intronic
chr16:48619289(-) A-I      intronic
chr16:48627830(-) A-I      intronic
chr16:48628542(-) A-I      intronic
chr16:48579855(-) A-I      intronic
chr16:48639137(-) A-I      intronic
chr16:48607497(-) A-I      intronic
chr16:48642000(-) A-I      intronic
chr16:48579367(-) A-I      intronic
chr16:48579843(-) A-I      intronic
chr16:48636121(-) A-I      intronic
chr16:48579354(-) A-I      intronic
chr16:48639136(-) A-I      intronic
chr16:48579932(-) A-I      intronic
chr16:48578905(-) A-I      intronic
chr16:48579403(-) A-I      intronic
chr16:48638355(-) A-I      intronic
chr16:48628485(-) A-I      intronic
chr16:48627801(-) A-I      intronic
chr16:48607337(-) A-I      intronic
chr16:48628406(-) A-I      intronic
chr16:48578978(-) A-I      intronic
chr16:48579774(-) A-I      intronic
chr16:48619801(-) A-I      intronic
chr16:48579113(-) A-I      intronic
chr16:48636861(-) A-I      intronic
chr16:48579905(-) A-I      intronic
chr16:48579734(-) A-I      intronic
chr16:48636842(-) A-I      intronic
chr16:48606838(-) A-I      intronic
chr16:48639016(-) A-I      intronic
chr16:48579901(-) A-I      intronic
chr16:48639032(-) A-I      intronic
chr16:48627994(-) A-I      intronic
chr16:48579118(-) A-I      intronic
chr16:48638265(-) A-I      intronic
chr16:48579236(-) A-I      intronic
chr16:48629211(-) A-I      intronic
chr16:48641911(-) A-I      intronic
chr16:48639081(-) A-I      intronic
chr16:48579014(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED N4BP1
chr16:48638265(-) A-G intron -    22484847
chr16:48638407(-) A-G intron -    22484847
chr16:48639081(-) A-G intron -    22484847
chr16:48639082(-) A-G intron -    22484847
chr16:48642000(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase N4BP1
chr16:48576510-48576511(-) m6A 3'UTR       27773535
chr16:48576562-48576563(-) m6A 3'UTR       27773535
chr16:48576651-48576652(-) m6A 3'UTR       24981863//27773535
chr16:48576720-48576721(-) m6A 3'UTR       24209618//24981863//27773535//22608085
chr16:48576735-48576736(-) m6A 3'UTR       24209618//24981863//27773535//22608085
chr16:48576768-48576769(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:48576881-48576882(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr16:48576892-48576893(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr16:48576945-48576946(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr16:48576980-48576981(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr16:48580024-48580025(-) m6A exon//intron       27773535
chr16:48587502-48587503(-) m6A CDS//exon       27773535
chr16:48594699-48594700(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr16:48594720-48594721(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr16:48594810-48594811(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr16:48594960-48594961(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr16:48595088-48595089(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595096-48595097(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595114-48595115(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595120-48595121(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595140-48595141(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr16:48595146-48595147(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr16:48595160-48595161(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr16:48595197-48595198(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr16:48595265-48595266(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr16:48595328-48595329(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr16:48595337-48595338(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr16:48595372-48595373(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr16:48595425-48595426(-) m6A CDS//exon       24284625//24981863//28052920//27773535//22608085
chr16:48595437-48595438(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr16:48595487-48595488(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr16:48595498-48595499(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr16:48595532-48595533(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr16:48595610-48595611(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr16:48595798-48595799(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr16:48595806-48595807(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr16:48595829-48595830(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595865-48595866(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595916-48595917(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595958-48595959(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48595998-48595999(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48596047-48596048(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48596070-48596071(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48596116-48596117(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr16:48596212-48596213(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr16:48596296-48596297(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr16:48596325-48596326(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr16:48596331-48596332(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
N4BP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: N4BP1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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