Basic Information:

  VIRBase ID:  

HHID00010368

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          RBM39:  NR_040723     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	RBM39
miRBase Accession/Entrez ID	MIMAT0004588	9584
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAPER//CAPERalpha//FSAP59//HCC1//RNPC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RBM39	chr20:34305730(-) A-I      intronic chr20:34305720(-) A-I      intronic chr20:34301705(-) A-I      intronic chr20:34301187(-) A-I      intronic chr20:34301133(-) A-I      intronic chr20:34301131(-) A-I      intronic chr20:34325955(-) A-I      intronic chr20:34329160(-) A-I      intronic chr20:34326021(-) A-I      intronic chr20:34325443(-) A-I      intronic chr20:34325423(-) A-I      intronic chr20:34324707(-) A-I      intronic chr20:34324662(-) A-I      intronic chr20:34316916(-) A-I      intronic chr20:34316889(-) A-I      intronic chr20:34313707(-) A-I      intronic chr20:34313701(-) A-I      intronic chr20:34313694(-) A-I      intronic chr20:34314856(-) A-I      intronic chr20:34314271(-) A-I      intronic chr20:34314163(-) A-I      intronic chr20:34314162(-) A-I      intronic chr20:34314150(-) A-I      intronic chr20:34314130(-) A-I      intronic chr20:34314126(-) A-I      intronic chr20:34314121(-) A-I      intronic chr20:34314095(-) A-I      intronic chr20:34313812(-) A-I      intronic chr20:34316941(-) A-I      intronic chr20:34316915(-) A-I      intronic chr20:34316898(-) A-I      intronic chr20:34316890(-) A-I      intronic chr20:34314868(-) A-I      intronic chr20:34313799(-) A-I      intronic chr20:34324742(-) A-I      intronic chr20:34324744(-) A-I      intronic chr20:34313652(-) A-I      intronic chr20:34313598(-) A-I      intronic chr20:34313578(-) A-I      intronic chr20:34313576(-) A-I      intronic chr20:34313575(-) A-I      intronic chr20:34313419(-) A-I      intronic chr20:34313416(-) A-I      intronic chr20:34313411(-) A-I      intronic chr20:34312185(-) A-I      intronic chr20:34312028(-) A-I      intronic chr20:34312010(-) A-I      intronic chr20:34311997(-) A-I      intronic chr20:34311880(-) A-I      intronic chr20:34311648(-) A-I      intronic chr20:34311539(-) A-I      intronic chr20:34325370(-) A-I      intronic chr20:34325430(-) A-I      intronic chr20:34325440(-) A-I      intronic chr20:34325649(-) A-I      intronic chr20:34325656(-) A-I      intronic chr20:34311525(-) A-I      intronic chr20:34311517(-) A-I      intronic chr20:34311485(-) A-I      intronic chr20:34309402(-) A-I      intronic chr20:34309357(-) A-I      intronic chr20:34329228(-) A-I      intronic chr20:34326002(-) A-I      intronic chr20:34324746(-) A-I      intronic chr20:34324770(-) A-I      intronic chr20:34324808(-) A-I      intronic chr20:34315976(-) A-I      intronic chr20:34315509(-) A-I      intronic chr20:34315483(-) A-I      intronic chr20:34315210(-) A-I      intronic chr20:34315141(-) A-I      intronic chr20:34329196(-) A-I      intronic chr20:34329135(-) A-I      intronic chr20:34308944(-) A-I      intronic chr20:34308919(-) A-I      intronic chr20:34325991(-) A-I      intronic chr20:34308688(-) A-I      intronic chr20:34308650(-) A-I      intronic chr20:34308004(-) A-I      intronic chr20:34307932(-) A-I      intronic chr20:34307816(-) A-I      intronic chr20:34325684(-) A-I      intronic chr20:34307729(-) A-I      intronic chr20:34307487(-) A-I      intronic chr20:34306659(-) A-I      intronic chr20:34306611(-) A-I      intronic chr20:34306490(-) A-I      intronic chr20:34306426(-) A-I      intronic chr20:34305064(-) A-I      intronic chr20:34305074(-) A-I      intronic chr20:34305115(-) A-I      intronic chr20:34305816(-) A-I      intronic chr20:34305841(-) A-I      intronic chr20:34305866(-) A-I      intronic chr20:34305896(-) A-I      intronic chr20:34305909(-) A-I      intronic chr20:34328994(-) A-I      intronic chr20:34314915(-) A-I      intronic chr20:34326133(-) A-I      intronic chr20:34306048(-) A-I      intronic chr20:34326127(-) A-I      intronic chr20:34326016(-) A-I      intronic chr20:34324829(-) A-I      intronic chr20:34324837(-) A-I      intronic chr20:34300173(-) A-I      intronic chr20:34300194(-) A-I      intronic chr20:34300211(-) A-I      intronic chr20:34300269(-) A-I      intronic chr20:34300272(-) A-I      intronic chr20:34301158(-) A-I      intronic chr20:34301300(-) A-I      intronic chr20:34301350(-) A-I      intronic chr20:34301376(-) A-I      intronic chr20:34300208(-) A-I      intronic chr20:34301380(-) A-I      intronic chr20:34301386(-) A-I      intronic chr20:34301484(-) A-I      intronic chr20:34301511(-) A-I      intronic chr20:34304556(-) A-I      intronic chr20:34325071(-) A-I      intronic chr20:34324681(-) A-I      intronic chr20:34324670(-) A-I      intronic chr20:34324669(-) A-I      intronic chr20:34316952(-) A-I      intronic chr20:34307477(-) A-I      intronic chr20:34315982(-) A-I      intronic chr20:34301359(-) A-I      intronic chr20:34305765(-) A-I      intronic chr20:34315536(-) A-I      intronic chr20:34324611(-) A-I      intronic chr20:34314328(-) A-I      intronic chr20:34316886(-) A-I      intronic chr20:34312009(-) A-I      intronic chr20:34326000(-) A-I      intronic chr20:34316756(-) A-I      intronic chr20:34307898(-) A-I      intronic chr20:34304966(-) A-I      intronic chr20:34315981(-) A-I      intronic chr20:34315226(-) A-I      intronic chr20:34312210(-) A-I      intronic chr20:34324745(-) A-I      intronic chr20:34312154(-) A-I      intronic chr20:34306454(-) A-I      intronic chr20:34324852(-) A-I      intronic chr20:34325031(-) A-I      intronic chr20:34308956(-) A-I      intronic chr20:34313697(-) A-I      intronic chr20:34325598(-) A-I      intronic chr20:34305116(-) A-I      intronic chr20:34325659(-) A-I      intronic chr20:34324962(-) A-I      intronic chr20:34312142(-) A-I      intronic chr20:34307118(-) A-I      intronic chr20:34325882(-) A-I      intronic chr20:34315576(-) A-I      intronic chr20:34314756(-) A-I      intronic chr20:34301372(-) A-I      intronic chr20:34325164(-) A-I      intronic chr20:34307181(-) A-I      intronic chr20:34324802(-) A-I      intronic chr20:34310282(-) A-I      intronic chr20:34314911(-) A-I      intronic chr20:34311610(-) A-I      intronic chr20:34315180(-) A-I      intronic chr20:34324678(-) A-I      intronic chr20:34325582(-) A-I      intronic chr20:34301353(-) A-I      intronic chr20:34311498(-) A-I      intronic chr20:34314914(-) A-I      intronic chr20:34306489(-) A-I      intronic chr20:34316957(-) A-I      intronic chr20:34326012(-) A-I      intronic chr20:34307828(-) A-I      intronic chr20:34325913(-) A-I      intronic chr20:34310739(-) A-I      intronic chr20:34301192(-) A-I      intronic chr20:34300146(-) A-I      intronic chr20:34301324(-) A-I      intronic chr20:34311428(-) A-I      intronic chr20:34304967(-) A-I      intronic chr20:34311499(-) A-I      intronic chr20:34301191(-) A-I      intronic chr20:34324779(-) A-I      intronic chr20:34305719(-) A-I      intronic chr20:34316850(-) A-I      intronic chr20:34314258(-) A-I      intronic chr20:34307998(-) A-I      intronic chr20:34306530(-) A-I      intronic chr20:34325957(-) A-I      intronic chr20:34315096(-) A-I      intronic chr20:34313449(-) A-I      intronic chr20:34301528(-) A-I      intronic chr20:34315241(-) A-I      intronic chr20:34305166(-) A-I      intronic chr20:34325996(-) A-I      intronic chr20:34314259(-) A-I      intronic chr20:34300134(-) A-I      intronic chr20:34316749(-) A-I      intronic chr20:34307988(-) A-I      intronic chr20:34316755(-) A-I      intronic chr20:34310085(-) A-I      intronic chr20:34324769(-) A-I      intronic chr20:34309027(-) A-I      intronic chr20:34301520(-) A-I      intronic chr20:34311745(-) A-I      intronic chr20:34314937(-) A-I      intronic chr20:34307523(-) A-I      intronic chr20:34301479(-) A-I      intronic chr20:34324754(-) A-I      intronic chr20:34316803(-) A-I      intronic chr20:34325360(-) A-I      intronic chr20:34325212(-) A-I      intronic chr20:34314228(-) A-I      intronic chr20:34311847(-) A-I      intronic chr20:34311712(-) A-I      intronic chr20:34315137(-) A-I      intronic chr20:34308526(-) A-I      intronic chr20:34325540(-) A-I      intronic chr20:34301154(-) A-I      intronic chr20:34301315(-) A-I      intronic chr20:34306850(-) A-I      intronic chr20:34315076(-) A-I      intronic chr20:34325607(-) A-I      intronic chr20:34301686(-) A-I      intronic chr20:34305667(-) A-I      intronic chr20:34325528(-) A-I      intronic chr20:34325055(-) A-I      intronic chr20:34314273(-) A-I      intronic chr20:34311458(-) A-I      intronic chr20:34324936(-) A-I      intronic chr20:34308571(-) A-I      intronic chr20:34301692(-) A-I      intronic chr20:34315789(-) A-I      intronic chr20:34315663(-) A-I      intronic chr20:34306531(-) A-I      intronic chr20:34300223(-) A-I      intronic chr20:34306623(-) A-I      intronic chr20:34325477(-) A-I      intronic chr20:34315225(-) A-I      intronic chr20:34305707(-) A-I      intronic chr20:34325419(-) A-I      intronic chr20:34325190(-) A-I      intronic chr20:34324778(-) A-I      intronic chr20:34312172(-) A-I      intronic chr20:34312132(-) A-I      intronic chr20:34304529(-) A-I      intronic chr20:34307451(-) A-I      intronic chr20:34305119(-) A-I      intronic chr20:34314901(-) A-I      intronic chr20:34325057(-) A-I      intronic chr20:34315913(-) A-I      intronic chr20:34313754(-) A-I      intronic chr20:34307419(-) A-I      intronic chr20:34325400(-) A-I      intronic chr20:34324743(-) A-I      intronic chr20:34312057(-) A-I      intronic chr20:34305919(-) A-I      intronic chr20:34307813(-) A-I      intronic chr20:34325146(-) A-I      intronic chr20:34315787(-) A-I      intronic chr20:34325013(-) A-I      intronic chr20:34315471(-) A-I      intronic chr20:34299929(-) A-I      intronic chr20:34305987(-) A-I      intronic chr20:34307186(-) A-I      intronic chr20:34305668(-) A-I      intronic chr20:34306587(-) A-I      intronic chr20:34324721(-) A-I      intronic chr20:34312171(-) A-I      intronic chr20:34316912(-) A-I      intronic chr20:34305976(-) A-I      intronic chr20:34301760(-) A-I      intronic chr20:34315936(-) A-I      intronic chr20:34314759(-) A-I      intronic chr20:34325888(-) A-I      intronic chr20:34316770(-) A-I      intronic chr20:34314325(-) A-I      intronic chr20:34324739(-) A-I      intronic chr20:34325016(-) A-I      intronic chr20:34310140(-) A-I      intronic chr20:34312247(-) A-I      intronic chr20:34301749(-) A-I      intronic chr20:34311446(-) A-I      intronic chr20:34325229(-) A-I      intronic chr20:34315578(-) A-I      intronic chr20:34324854(-) A-I      intronic chr20:34316903(-) A-I      intronic chr20:34325995(-) A-I      intronic chr20:34304997(-) A-I      intronic chr20:34310418(-) A-I      intronic chr20:34314815(-) A-I      intronic chr20:34325030(-) A-I      intronic chr20:34314192(-) A-I      intronic chr20:34325967(-) A-I      intronic chr20:34304957(-) A-I      intronic chr20:34325622(-) A-I      intronic chr20:34325456(-) A-I      intronic chr20:34324797(-) A-I      intronic chr20:34326015(-) A-I      intronic chr20:34325155(-) A-I      intronic chr20:34311489(-) A-I      intronic chr20:34314237(-) A-I      intronic chr20:34314320(-) A-I      intronic chr20:34316599(-) A-I      intronic chr20:34312091(-) A-I      intronic chr20:34301295(-) A-I      intronic chr20:34306826(-) A-I      intronic chr20:34301149(-) A-I      intronic chr20:34307499(-) A-I      intronic chr20:34305090(-) A-I      intronic chr20:34325249(-) A-I      intronic chr20:34316935(-) A-I      intronic chr20:34300147(-) A-I      intronic chr20:34325902(-) A-I      intronic chr20:34301412(-) A-I      intronic chr20:34325382(-) A-I      intronic chr20:34316837(-) A-I      intronic chr20:34325910(-) A-I      intronic chr20:34301519(-) A-I      intronic chr20:34324748(-) A-I      intronic chr20:34315508(-) A-I      intronic chr20:34315923(-) A-I      intronic chr20:34324937(-) A-I      intronic chr20:34315095(-) A-I      intronic chr20:34301186(-) A-I      intronic chr20:34324768(-) A-I      intronic chr20:34299915(-) A-I      intronic chr20:34314165(-) A-I      intronic chr20:34301385(-) A-I      intronic chr20:34315784(-) A-I      intronic chr20:34316817(-) A-I      intronic chr20:34313710(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RBM39	chr20:34311423(-) A-I intron -    15258596 chr20:34311428(-) A-I intron -    15258596 chr20:34311459(-) A-I intron -    15258596 chr20:34311466(-) A-I intron -    15258596 chr20:34301191(-) A-I intron -    21960545   //22327324 chr20:34301192(-) A-I intron -    21960545   //22327324 chr20:34301692(-) A-I intron -    22327324 chr20:34324713(-) A-I intron -    22327324 chr20:34324739(-) A-I intron -    22327324 chr20:34300290(-) C-T intron -    22484847 chr20:34301191(-) A-G intron -    22484847 chr20:34301192(-) A-G intron -    22484847 chr20:34301359(-) A-G intron -    22484847 chr20:34301533(-) A-G intron -    22484847 chr20:34301692(-) A-G intron -    22484847 chr20:34301749(-) A-G intron -    22484847 chr20:34305668(-) A-G intron -    22484847 chr20:34305765(-) A-G intron -    22484847 chr20:34310140(-) A-G intron -    22484847 chr20:34311459(-) A-G intron -    22484847 chr20:34314254(-) A-G intron -    22484847 chr20:34314815(-) A-G intron -    22484847 chr20:34315936(-) A-G intron -    22484847 chr20:34315982(-) A-G intron -    22484847 chr20:34316599(-) A-G intron -    22484847 chr20:34316803(-) A-G intron -    22484847 chr20:34316817(-) A-G intron -    22484847 chr20:34324635(-) A-G intron -    22484847 chr20:34324658(-) A-G intron -    22484847 chr20:34324684(-) A-G intron -    22484847 chr20:34324713(-) A-G intron -    22484847 chr20:34324739(-) A-G intron -    22484847 chr20:34325396(-) A-G intron -    22484847 chr20:34325400(-) A-G intron -    22484847 chr20:34325477(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RBM39	chr20:34293191-34293192(-) m6A 3'UTR//CDS//exon       26404942 chr20:34293246-34293247(-) m1A 3'UTR//CDS//exon       26863410 chr20:34313073-34313074(-) m6A 3'UTR//CDS//exon       24981863 chr20:34317248-34317249(-) m6A 3'UTR//CDS//exon       24981863 chr20:34317442-34317443(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr20:34319287-34319288(-) m6A 3'UTR//exon//intron       24981863//27773535 chr20:34319976-34319977(-) Gm 3'UTR//CDS//exon       - chr20:34319979-34319980(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//27773535//22575960//22608085 chr20:34320168-34320169(-) m6A exon//intron       24209618//24981863//27773535 chr20:34326931-34326932(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22575960 chr20:34327196-34327197(-) m6A exon//intron       26404942 chr20:34327266-34327267(-) m6A exon//intron       24981863//27773535 chr20:34327271-34327272(-) m6A exon//intron       24981863//27773535 chr20:34327278-34327279(-) m6A exon//intron       24981863//27773535 chr20:34327298-34327299(-) m6A exon//intron       24981863//27773535 chr20:34328668-34328669(-) m6A exon//intron       24209618//24981863 chr20:34328686-34328687(-) m6A exon//intron       24209618//24981863 chr20:34328734-34328735(-) m6A exon//intron       24209618//24981863 chr20:34329865-34329866(-) m6A 5'UTR//exon       24284625//24209618//24981863//22575960 chr20:34329896-34329897(-) m6A 5'UTR//exon       24284625//24209618//24981863//22575960 chr20:34330007-34330008(-) m6A 5'UTR//exon       24284625//24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RBM39	Chromatin HCC cell line (HepG2)|K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: RBM39

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).