Basic Information:

  VIRBase ID:  

HHID00010365

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          GTPBP1:  NM_004286     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	GTPBP1
miRBase Accession/Entrez ID	MIMAT0004588	9567
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GP-1//GP1//HSPC018

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GTPBP1	chr22:39108015(+) A-I      intronic chr22:39107583(+) A-I      intronic chr22:39108069(+) A-I      intronic chr22:39107651(+) A-I      intronic chr22:39107950(+) A-I      intronic chr22:39107985(+) A-I      intronic chr22:39107686(+) A-I      intronic chr22:39107589(+) A-I      intronic chr22:39107728(+) A-I      intronic chr22:39108154(+) A-I      intronic chr22:39107909(+) A-I      intronic chr22:39117270(+) A-I      intronic chr22:39110324(+) A-I      intronic chr22:39107986(+) A-I      intronic chr22:39107989(+) A-I      intronic chr22:39105177(+) A-I      intronic chr22:39107763(+) A-I      intronic chr22:39107741(+) A-I      intronic chr22:39107665(+) A-I      intronic chr22:39107727(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GTPBP1	chr22:39107665(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GTPBP1	chr22:39101991-39101992(+) m6A CDS//intron       24209618//24981863 chr22:39102093-39102094(+) m6A CDS//intron       24209618//24981863//22575960 chr22:39102138-39102139(+) m6A CDS//exon//intron       22575960 chr22:39102835-39102836(+) m6A 5'UTR//intron       - chr22:39104933-39104934(+) m6A CDS//exon//intron       24284625//24209618//24981863 chr22:39111916-39111917(+) m6A CDS//exon       24284625//24209618//24981863 chr22:39111981-39111982(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr22:39112070-39112071(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr22:39112108-39112109(+) m6A exon//intron       24284625//24209618//24981863//22575960 chr22:39112727-39112728(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112755-39112756(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112770-39112771(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr22:39112847-39112848(+) m6A 3'UTR//CDS       - chr22:39124010-39124011(+) m6A CDS       - chr22:39124021-39124022(+) Y CDS       26075521 chr22:39124032-39124033(+) m6A CDS       - chr22:39124038-39124039(+) m6A CDS       - chr22:39124056-39124057(+) m6A CDS       - chr22:39124088-39124089(+) m6A CDS       - chr22:39124110-39124111(+) m6A CDS       24981863 chr22:39124274-39124275(+) m6A exon//intron       24981863 chr22:39125475-39125476(+) m6A CDS//exon       24981863 chr22:39125497-39125498(+) m6A CDS//exon       24981863 chr22:39126709-39126710(+) m6A 3'UTR//exon//intron       24284625 chr22:39126894-39126895(+) m6A 3'UTR//exon//intron       24981863 chr22:39126905-39126906(+) m6A 3'UTR//exon//intron       24981863 chr22:39127831-39127832(+) Y 3'UTR//exon//intron       26075521 chr22:39127838-39127839(+) m6A 3'UTR//exon//intron       - chr22:39127882-39127883(+) m6A 3'UTR//exon//intron       25456834 chr22:39127899-39127900(+) m6A 3'UTR//exon//intron       25456834 chr22:39127924-39127925(+) m6A 3'UTR//exon//intron       25456834 chr22:39127942-39127943(+) m6A 3'UTR//exon//intron       25456834 chr22:39127976-39127977(+) m6A 3'UTR//exon//intron       25456834 chr22:39127986-39127987(+) m6A 3'UTR//exon//intron       25456834 chr22:39128061-39128062(+) m6A 3'UTR//exon//intron       25456834 chr22:39128836-39128837(+) m6A 3'UTR//intron       24209618 chr22:39128887-39128888(+) m6A 3'UTR//intron       24209618 chr22:39130223-39130224(+) m6A 3'UTR//intron       - chr22:39130232-39130233(+) m6A 3'UTR//intron       - chr22:39131230-39131231(+) m6A CDS//intron       - chr22:39132123-39132124(+) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//26404942 chr22:39134224-39134225(+) m6A 3'UTR       27773535 chr22:39134266-39134267(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	GTPBP1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: GTPBP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).