Detail Information

Basic Information:


  VIRBase ID:  

HHID00010336

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           MED14:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p MED14
miRBase
Accession/Entrez ID		 MIMAT0004588 9282
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CRSP150//CRSP2//CSRP//CXorf4//DRIP150//EXLM1//RGR1//TRAP170

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MED14
chrX:40577869(-) A-I      intronic
chrX:40566253(-) A-I      intronic
chrX:40566250(-) A-I      intronic
chrX:40548896(-) A-I      intronic
chrX:40548701(-) A-I      intronic
chrX:40547383(-) A-I      intronic
chrX:40547357(-) A-I      intronic
chrX:40518063(-) A-I      intronic
chrX:40517923(-) A-I      intronic
chrX:40517590(-) A-I      intronic
chrX:40517548(-) A-I      intronic
chrX:40517538(-) A-I      intronic
chrX:40517537(-) A-I      intronic
chrX:40517325(-) A-I      intronic
chrX:40517303(-) A-I      intronic
chrX:40577865(-) A-I      intronic
chrX:40577868(-) A-I      intronic
chrX:40566256(-) A-I      intronic
chrX:40548904(-) A-I      intronic
chrX:40592601(-) A-I      intronic
chrX:40592496(-) A-I      intronic
chrX:40591910(-) A-I      intronic
chrX:40517302(-) A-I      intronic
chrX:40577064(-) A-I      intronic
chrX:40576886(-) A-I      intronic
chrX:40568339(-) A-I      intronic
chrX:40566437(-) A-I      intronic
chrX:40566296(-) A-I      intronic
chrX:40566295(-) A-I      intronic
chrX:40566292(-) A-I      intronic
chrX:40517200(-) A-I      intronic
chrX:40566291(-) A-I      intronic
chrX:40566268(-) A-I      intronic
chrX:40559220(-) A-I      intronic
chrX:40559237(-) A-I      intronic
chrX:40559256(-) A-I      intronic
chrX:40559257(-) A-I      intronic
chrX:40559258(-) A-I      intronic
chrX:40559263(-) A-I      intronic
chrX:40559266(-) A-I      intronic
chrX:40559279(-) A-I      intronic
chrX:40577826(-) A-I      intronic
chrX:40577828(-) A-I      intronic
chrX:40517318(-) A-I      intronic
chrX:40549763(-) A-I      intronic
chrX:40592539(-) A-I      intronic
chrX:40591649(-) A-I      intronic
chrX:40592513(-) A-I      intronic
chrX:40568333(-) A-I      intronic
chrX:40590251(-) A-I      intronic
chrX:40591709(-) A-I      intronic
chrX:40577940(-) A-I      intronic
chrX:40577939(-) A-I      intronic
chrX:40517182(-) A-I      intronic
chrX:40590236(-) A-I      intronic
chrX:40521393(-) A-I      intronic
chrX:40592549(-) A-I      intronic
chrX:40551046(-) A-I      intronic
chrX:40591688(-) A-I      intronic
chrX:40517073(-) A-I      intronic
chrX:40592556(-) A-I      intronic
chrX:40592628(-) A-I      intronic
chrX:40517439(-) A-I      intronic
chrX:40576939(-) A-I      intronic
chrX:40590252(-) A-I      intronic
chrX:40592520(-) A-I      intronic
chrX:40576872(-) A-I      intronic
chrX:40568308(-) A-I      intronic
chrX:40582755(-) A-I      intronic
chrX:40517249(-) A-I      intronic
chrX:40517929(-) A-I      intronic
chrX:40592547(-) A-I      intronic
chrX:40520331(-) A-I      intronic
chrX:40517547(-) A-I      intronic
chrX:40548940(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MED14
chrX:40528429(-) A-I intron -    21960545
chrX:40529587(-) A-I intron -    21960545
chrX:40529571(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MED14
chrX:40510531-40510532(-) m6A 3'UTR//intron       27773535
chrX:40510543-40510544(-) m6A 3'UTR//intron       27773535
chrX:40510573-40510574(-) m6A 3'UTR//intron       27773535
chrX:40510646-40510647(-) m6A 3'UTR//intron       27773535
chrX:40510656-40510657(-) m6A 3'UTR//intron       27773535
chrX:40510758-40510759(-) m6A 3'UTR//intron       27773535
chrX:40510846-40510847(-) m6A 3'UTR//intron       24981863//27773535//22608085
chrX:40510870-40510871(-) m6A 3'UTR//intron       24981863//27773535//22608085
chrX:40510934-40510935(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40510957-40510958(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40510970-40510971(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40511018-40511019(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40511040-40511041(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40511056-40511057(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chrX:40513689-40513690(-) m6A CDS       -
chrX:40513697-40513698(-) m6A CDS       -
chrX:40513707-40513708(-) m6A CDS       -
chrX:40513769-40513770(-) m6A CDS       27773535
chrX:40513789-40513790(-) m6A CDS       27773535
chrX:40518774-40518775(-) m6A CDS//exon       27773535
chrX:40518813-40518814(-) m6A CDS//exon       27773535
chrX:40518835-40518836(-) m6A CDS//exon       27773535
chrX:40518927-40518928(-) m6A exon//intron       27773535
chrX:40522312-40522313(-) m6A CDS       27773535
chrX:40522371-40522372(-) m6A CDS       27773535
chrX:40522390-40522391(-) m6A CDS       27773535
chrX:40522403-40522404(-) m6A CDS       27773535
chrX:40523561-40523562(-) m6A CDS       27773535
chrX:40523683-40523684(-) m6A CDS       27773535
chrX:40523738-40523739(-) m6A CDS       27773535
chrX:40525999-40526000(-) m6A CDS       27773535
chrX:40531202-40531203(-) m6A CDS       24981863//27773535
chrX:40539121-40539122(-) m6A CDS//intron       27773535
chrX:40552077-40552078(-) Cm CDS       -
chrX:40573117-40573118(-) m6A CDS//exon       -
chrX:40573139-40573140(-) m6A CDS//exon       -
chrX:40573918-40573919(-) m6A CDS//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MED14
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: MED14

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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