Detail Information

Basic Information:


  VIRBase ID:  

HHID00010288

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           PRKRA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p PRKRA
miRBase
Accession/Entrez ID		 MIMAT0004588 8575
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DYT16//HSD14//PACT//RAX

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRKRA
chr2:179300058(-) A-I      intronic
chr2:179300064(-) A-I      intronic
chr2:179300066(-) A-I      intronic
chr2:179310789(-) A-I      intronic
chr2:179298940(-) A-I      intronic
chr2:179300074(-) A-I      intronic
chr2:179310780(-) A-I      intronic
chr2:179298943(-) A-I      intronic
chr2:179298966(-) A-I      intronic
chr2:179298975(-) A-I      intronic
chr2:179300047(-) A-I      intronic
chr2:179300048(-) A-I      intronic
chr2:179310898(-) A-I      intronic
chr2:179310890(-) A-I      intronic
chr2:179310547(-) A-I      intronic
chr2:179310534(-) A-I      intronic
chr2:179310880(-) A-I      intronic
chr2:179310725(-) A-I      intronic
chr2:179310663(-) A-I      intronic
chr2:179310653(-) A-I      intronic
chr2:179310641(-) A-I      intronic
chr2:179310638(-) A-I      intronic
chr2:179310632(-) A-I      intronic
chr2:179311663(-) A-I      intronic
chr2:179311657(-) A-I      intronic
chr2:179311620(-) A-I      intronic
chr2:179311611(-) A-I      intronic
chr2:179311608(-) A-I      intronic
chr2:179311598(-) A-I      intronic
chr2:179311572(-) A-I      intronic
chr2:179311571(-) A-I      intronic
chr2:179311539(-) A-I      intronic
chr2:179311531(-) A-I      intronic
chr2:179311492(-) A-I      intronic
chr2:179310961(-) A-I      intronic
chr2:179310946(-) A-I      intronic
chr2:179310945(-) A-I      intronic
chr2:179310938(-) A-I      intronic
chr2:179310937(-) A-I      intronic
chr2:179310935(-) A-I      intronic
chr2:179310606(-) A-I      intronic
chr2:179310625(-) A-I      intronic
chr2:179310915(-) A-I      intronic
chr2:179310906(-) A-I      intronic
chr2:179310902(-) A-I      intronic
chr2:179310622(-) A-I      intronic
chr2:179310879(-) A-I      intronic
chr2:179310809(-) A-I      intronic
chr2:179310596(-) A-I      intronic
chr2:179310595(-) A-I      intronic
chr2:179310543(-) A-I      intronic
chr2:179310700(-) A-I      intronic
chr2:179306727(-) A-I      intronic
chr2:179310550(-) A-I      intronic
chr2:179310814(-) A-I      intronic
chr2:179310634(-) A-I      intronic
chr2:179299988(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PRKRA
chr2:179298405(-) A-I intron -    22327324
chr2:179299291(-) A-I intron -    22327324
chr2:179299628(-) A-I intron -    22327324
chr2:179299647(-) A-I intron -    22327324
chr2:179299662(-) A-I intron -    22327324
chr2:179299758(-) A-I intron -    22327324
chr2:179299864(-) A-I intron -    22327324
chr2:179299876(-) A-I intron -    22327324
chr2:179299883(-) A-I intron -    22327324
chr2:179300016(-) A-I intron -    22327324
chr2:179300030(-) A-I intron -    22327324
chr2:179300031(-) A-I intron -    22327324
chr2:179303617(-) A-I intron -    22327324
chr2:179303641(-) A-I intron -    22327324
chr2:179310809(-) A-I intron -    22327324
chr2:179310815(-) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRKRA
chr2:179315103-179315104(-) m6A CDS//exon       -
chr2:179315207-179315208(-) m6A 5'UTR//intron       27773536
chr2:179315245-179315246(-) m6A 5'UTR//intron       27773536
chr2:179315699-179315700(-) m6A 5'UTR//CDS//exon       27371828//27773536
chr2:179315707-179315708(-) m6A 5'UTR//CDS//exon       25456834//27371828//27773536//22575960
chr2:179315829-179315830(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PRKRA
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: PRKRA

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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