Detail Information

Basic Information:


  VIRBase ID:  

HHID00010279

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           CNTNAP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p CNTNAP1
miRBase
Accession/Entrez ID		 MIMAT0004588 8506
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CASPR//CHN3//CNTNAP//NRXN4//P190

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CNTNAP1
chr17:40837701(+) A-I      intronic
chr17:40848937(+) A-I      intronic
chr17:40848930(+) A-I      intronic
chr17:40848503(+) A-I      intronic
chr17:40848422(+) A-I      intronic
chr17:40848442(+) A-I      intronic
chr17:40848411(+) A-I      intronic
chr17:40848421(+) A-I      intronic
chr17:40848717(+) A-I      intronic
chr17:40848784(+) A-I      intronic
chr17:40848800(+) A-I      intronic
chr17:40848982(+) A-I      intronic
chr17:40848367(+) A-I      intronic
chr17:40846412(+) A-I      intronic
chr17:40845861(+) A-I      intronic
chr17:40848765(+) A-I      intronic
chr17:40846347(+) A-I      intronic
chr17:40846563(+) A-I      intronic
chr17:40848713(+) A-I      intronic
chr17:40848550(+) A-I      intronic
chr17:40848617(+) A-I      intronic
chr17:40846294(+) A-I      intronic
chr17:40845825(+) A-I      intronic
chr17:40845854(+) A-I      intronic
chr17:40845963(+) A-I      intronic
chr17:40848914(+) A-I      intronic
chr17:40845839(+) A-I      intronic
chr17:40842426(+) A-I      intronic
chr17:40848588(+) A-I      intronic
chr17:40845856(+) A-I      intronic
chr17:40845902(+) A-I      intronic
chr17:40845996(+) A-I      intronic
chr17:40845807(+) A-I      intronic
chr17:40846503(+) A-I      intronic
chr17:40846387(+) A-I      intronic
chr17:40846654(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CNTNAP1
chr17:40846532(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CNTNAP1
chr17:40834642-40834643(+) m6A 5'UTR       24209618//25456834//24981863
chr17:40834649-40834650(+) m6A 5'UTR       24209618//25456834//24981863
chr17:40834684-40834685(+) m6A 5'UTR       24209618//25456834//24981863
chr17:40834755-40834756(+) m6A 5'UTR       24209618//25456834//24981863
chr17:40834788-40834789(+) m6A 5'UTR       24209618//24981863
chr17:40834833-40834834(+) m6A 5'UTR       24209618//24981863
chr17:40839870-40839871(+) m6A CDS//exon       27371828
chr17:40851093-40851094(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
CNTNAP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: CNTNAP1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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