Detail Information

Basic Information:


  VIRBase ID:  

HHID00010266

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           FZD8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p FZD8
miRBase
Accession/Entrez ID		 MIMAT0004588 8325
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FZ-8//hFZ8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FZD8
chr10:35927359-35927360(-) m6A 3'UTR       24981863
chr10:35927402-35927403(-) m6A 3'UTR       24981863
chr10:35927462-35927463(-) m6A 3'UTR       24981863//27773535
chr10:35927864-35927865(-) m6A 3'UTR       24284625//27773535
chr10:35927897-35927898(-) m6A 3'UTR       24284625//24981863//27773535
chr10:35927971-35927972(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr10:35927990-35927991(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr10:35928068-35928069(-) m6A 3'UTR       24284625//24981863//26404942//22608085
chr10:35928097-35928098(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr10:35928117-35928118(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr10:35928143-35928144(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr10:35928205-35928206(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr10:35928642-35928643(-) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr10:35928921-35928922(-) m6A CDS       24284625//25456834//24981863//27773536
chr10:35929597-35929598(-) m6A CDS       24284625//24981863
chr10:35929908-35929909(-) m6A CDS       24209618//25456834//24981863//26404942//27773536//22575960
chr10:35930061-35930062(-) m6A CDS       24284625//25456834//24981863//26404942//27773536//22575960//22608085
chr10:35930464-35930465(-) m6A 5'UTR       -
chr10:35930493-35930494(-) m6A 5'UTR       -
chr10:35930591-35930592(-) m6A 5'UTR       -
chr10:35930621-35930622(-) m6A 5'UTR       -
chr10:35930629-35930630(-) m6A 5'UTR       -
chr10:35930797-35930798(-) m6A 5'UTR       -
chr10:35931079-35931080(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FZD8
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: FZD8

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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