Detail Information

Basic Information:


  VIRBase ID:  

HHID00010247

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           TRIM25:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p TRIM25
miRBase
Accession/Entrez ID		 MIMAT0004588 7706
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EFP//RNF147//Z147//ZNF147

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM25
chr17:54983917(-) A-I      intronic
chr17:54983310(-) A-I      intronic
chr17:54984137(-) A-I      intronic
chr17:54982581(-) A-I      intronic
chr17:54984144(-) A-I      intronic
chr17:54983127(-) A-I      intronic
chr17:54990368(-) A-I      intronic
chr17:54983238(-) A-I      intronic
chr17:54983262(-) A-I      intronic
chr17:54983101(-) A-I      intronic
chr17:54982662(-) A-I      intronic
chr17:54983993(-) A-I      intronic
chr17:54983951(-) A-I      intronic
chr17:54982577(-) A-I      intronic
chr17:54984059(-) A-I      intronic
chr17:54982601(-) A-I      intronic
chr17:54983995(-) A-I      intronic
chr17:54982585(-) A-I      intronic
chr17:54965860(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRIM25
chr17:54973875(-) C-T intron -    22484847
chr17:54982577(-) A-G intron -    22484847
chr17:54965860(-) A-G exon 3'UTR    22484847
chr17:54990654(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM25
chr17:54965284-54965285(-) m6A 3'UTR       28052920//27773535//22608085
chr17:54965340-54965341(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965350-54965351(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//22608085
chr17:54965456-54965457(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965463-54965464(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965475-54965476(-) m6A 3'UTR       24284625//24981863//28052920//22608085
chr17:54965528-54965529(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54965590-54965591(-) m6A 3'UTR       24284625//24981863//22608085
chr17:54966028-54966029(-) m6A 3'UTR       -
chr17:54966062-54966063(-) m6A 3'UTR       -
chr17:54967981-54967982(-) m6A 3'UTR//exon       24284625
chr17:54968194-54968195(-) m6A 3'UTR//exon       24284625//24981863//22575960
chr17:54968394-54968395(-) m6A 3'UTR//exon       24284625
chr17:54968401-54968402(-) m6A 3'UTR//exon       24284625
chr17:54968499-54968500(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968524-54968525(-) m6A 3'UTR//exon       24284625//24981863
chr17:54968581-54968582(-) m6A 3'UTR//exon       24284625
chr17:54968989-54968990(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969015-54969016(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr17:54969136-54969137(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960
chr17:54969251-54969252(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969352-54969353(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969391-54969392(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:54969493-54969494(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54969568-54969569(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:54972719-54972720(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972739-54972740(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535
chr17:54972771-54972772(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535
chr17:54972897-54972898(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54972915-54972916(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr17:54973248-54973249(-) m6A exon//intron       24981863
chr17:54973290-54973291(-) m6A 3'UTR//CDS//exon       24981863
chr17:54976371-54976372(-) m6A exon//intron       24981863
chr17:54978838-54978839(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:54978877-54978878(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978882-54978883(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54978927-54978928(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981654-54981655(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981674-54981675(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54981773-54981774(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//27371828
chr17:54981838-54981839(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985847-54985848(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54985906-54985907(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr17:54989481-54989482(-) m6A CDS//intron       27371828
chr17:54989506-54989507(-) m6A CDS//intron       27371828
chr17:54989511-54989512(-) m6A CDS//intron       27371828
chr17:54990924-54990925(-) m6A CDS       24284625
chr17:54991152-54991153(-) m6A CDS       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TRIM25
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: TRIM25

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...