Detail Information

Basic Information:


  VIRBase ID:  

HHID00010238

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           ZFP36:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p ZFP36
miRBase
Accession/Entrez ID		 MIMAT0004588 7538
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZFP36
chr19:39897641-39897642(+) m6A CDS//intron       24981863
chr19:39897729-39897730(+) m6A CDS//intron       24981863
chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863
chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863
chr19:39898115-39898116(+) m6A CDS//intron       25456834
chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834
chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625
chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942
chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942
chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863
chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863
chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863
chr19:39899168-39899169(+) m6A CDS       24284625//24981863
chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942
chr19:39899703-39899704(+) m6A 3'UTR       27773535
chr19:39899735-39899736(+) m6A 3'UTR       27773535
chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ZFP36
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: ZFP36

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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