Detail Information

Basic Information:


  VIRBase ID:  

HHID00010221

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           UBTF:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p UBTF
miRBase
Accession/Entrez ID		 MIMAT0004588 7343
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CONDBA//NOR-90//UBF//UBF-1//UBF1//UBF2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UBTF
chr17:42285600(-) A-I      intronic
chr17:42286309(-) A-I      intronic
chr17:42286480(-) A-I      intronic
chr17:42285690(-) A-I      intronic
chr17:42286474(-) A-I      intronic
chr17:42285580(-) A-I      intronic
chr17:42285610(-) A-I      intronic
chr17:42285746(-) A-I      intronic
chr17:42286475(-) A-I      intronic
chr17:42286305(-) A-I      intronic
chr17:42286553(-) A-I      intronic
chr17:42286413(-) A-I      intronic
chr17:42285691(-) A-I      intronic
chr17:42286425(-) A-I      intronic
chr17:42285543(-) A-I      intronic
chr17:42285636(-) A-I      intronic
chr17:42286405(-) A-I      intronic
chr17:42286296(-) A-I      intronic
chr17:42285745(-) A-I      intronic
chr17:42285574(-) A-I      intronic
chr17:42286501(-) A-I      intronic
chr17:42285569(-) A-I      intronic
chr17:42285538(-) A-I      intronic
chr17:42285699(-) A-I      intronic
chr17:42285729(-) A-I      intronic
chr17:42286415(-) A-I      intronic
chr17:42285762(-) A-I      intronic
chr17:42286374(-) A-I      intronic
chr17:42285648(-) A-I      intronic
chr17:42285620(-) A-I      intronic
chr17:42285737(-) A-I      intronic
chr17:42285560(-) A-I      intronic
chr17:42286308(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UBTF
chr17:42285610(-) A-G intron -    22484847
chr17:42285636(-) A-G intron -    22484847
chr17:42286474(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UBTF
chr17:42282940-42282941(-) m6A 3'UTR       24981863
chr17:42282961-42282962(-) m6A 3'UTR       24981863
chr17:42283044-42283045(-) m6A 3'UTR       24981863
chr17:42283427-42283428(-) m6A 3'UTR       -
chr17:42283899-42283900(-) m6A 3'UTR       27773535
chr17:42284053-42284054(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr17:42284109-42284110(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr17:42284144-42284145(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:42284158-42284159(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:42284172-42284173(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284205-42284206(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284296-42284297(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284303-42284304(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284352-42284353(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284368-42284369(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284382-42284383(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284412-42284413(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284429-42284430(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284625-42284626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284634-42284635(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:42284888-42284889(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr17:42284912-42284913(-) m1A 3'UTR//CDS       26863196
chr17:42285086-42285087(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr17:42285103-42285104(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960
chr17:42285262-42285263(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960
chr17:42286015-42286016(-) m6A 3'UTR//intron       24981863//27773535
chr17:42286025-42286026(-) m6A 3'UTR//intron       24981863//27773535
chr17:42286144-42286145(-) m6A 3'UTR//intron       27773535
chr17:42286152-42286153(-) m6A 3'UTR//intron       27773535
chr17:42286177-42286178(-) m6A 3'UTR//intron       27773535
chr17:42286243-42286244(-) m6A 3'UTR//intron       27773535
chr17:42286675-42286676(-) m6A exon//intron       24981863
chr17:42286690-42286691(-) m6A exon//intron       24981863
chr17:42286703-42286704(-) m6A exon//intron       24981863
chr17:42286732-42286733(-) m6A CDS//exon       24981863//27773535//27371828
chr17:42286858-42286859(-) m6A CDS//exon       24284625//24981863//27371828//27773536//22575960
chr17:42287029-42287030(-) m6A CDS//exon       24284625//24981863//27371828
chr17:42287507-42287508(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960
chr17:42287536-42287537(-) m6A CDS       24284625//24209618//24981863//27773535//22575960
chr17:42288318-42288319(-) m6A 5'UTR//intron       24284625//24209618//27371828//27773536//22575960
chr17:42288339-42288340(-) m6A 5'UTR//intron       24284625//24209618//27371828//27773536//22575960
chr17:42288365-42288366(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr17:42288467-42288468(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr17:42289112-42289113(-) m6A CDS       24284625//27773535//27371828//27773536
chr17:42289273-42289274(-) m6A CDS       24284625//27773535//27371828//27773536
chr17:42289333-42289334(-) m6A CDS       24981863//27773535//27371828//27773536
chr17:42289360-42289361(-) m6A CDS       24981863//27773535//27371828//27773536
chr17:42289766-42289767(-) m6A CDS//exon//intron       24981863//27371828
chr17:42289799-42289800(-) m6A CDS//exon//intron       24981863//27773535//27371828//27773536
chr17:42290245-42290246(-) m6A CDS//exon       24981863//26404942//27773535//27371828//27773536
chr17:42290265-42290266(-) m6A CDS//exon       24981863//26404942//27773535//27371828//27773536
chr17:42290600-42290601(-) m6A CDS//exon       24981863//26404942//27773535//27371828//27773536
chr17:42290617-42290618(-) m6A CDS//exon       24981863//27773535//27371828//27773536
chr17:42290633-42290634(-) m6A CDS//exon       24981863//27773535//27371828//27773536
chr17:42292815-42292816(-) m6A exon//intron       24284625
chr17:42293933-42293934(-) m6A CDS//exon       27371828
chr17:42293945-42293946(-) m6A CDS//exon       27371828
chr17:42293969-42293970(-) m6A CDS//exon       27371828
chr17:42293988-42293989(-) m6A CDS//exon       26404942//27371828//27773536
chr17:42294023-42294024(-) m6A CDS//exon       26404942//27371828//27773536
chr17:42294053-42294054(-) m6A CDS//exon       24284625//26404942//27371828//27773536
chr17:42295568-42295569(-) m6A CDS//exon       24284625//27371828//27773536
chr17:42295607-42295608(-) m6A 5'UTR//exon       24284625//25456834//27371828//27773536
chr17:42295682-42295683(-) m6A 5'UTR//exon//intron       24284625//25456834//27371828//27773536//22608085
chr17:42295752-42295753(-) m6A 5'UTR//exon//intron       27371828
chr17:42295798-42295799(-) m6A 5'UTR//exon//intron       27371828
chr17:42298685-42298686(-) m6A 5'UTR       25456834
chr17:42298819-42298820(-) m6A 5'UTR       25456834//27371828//27773536
chr17:42298829-42298830(-) m6A 5'UTR       25456834//27371828//27773536
chr17:42298991-42298992(-) m6A 5'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
UBTF
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: UBTF

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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