Detail Information

Basic Information:


  VIRBase ID:  

HHID00010215

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           TRPS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p TRPS1
miRBase
Accession/Entrez ID		 MIMAT0004588 7227
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GC79//LGCR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRPS1
chr8:116651569(-) A-I      intronic
chr8:116512497(-) A-I      intronic
chr8:116512450(-) A-I      intronic
chr8:116512434(-) A-I      intronic
chr8:116512427(-) A-I      intronic
chr8:116512397(-) A-I      intronic
chr8:116500790(-) A-I      intronic
chr8:116500780(-) A-I      intronic
chr8:116500692(-) A-I      intronic
chr8:116512324(-) A-I      intronic
chr8:116512957(-) A-I      intronic
chr8:116651405(-) A-I      intronic
chr8:116468118(-) A-I      intronic
chr8:116500674(-) A-I      intronic
chr8:116513020(-) A-I      intronic
chr8:116482037(-) A-I      intronic
chr8:116481975(-) A-I      intronic
chr8:116481828(-) A-I      intronic
chr8:116481822(-) A-I      intronic
chr8:116513042(-) A-I      intronic
chr8:116536595(-) A-I      intronic
chr8:116471489(-) A-I      intronic
chr8:116536644(-) A-I      intronic
chr8:116512961(-) A-I      intronic
chr8:116455291(-) A-I      intronic
chr8:116468085(-) A-I      intronic
chr8:116468105(-) A-I      intronic
chr8:116468109(-) A-I      intronic
chr8:116468167(-) A-I      intronic
chr8:116560427(-) A-I      intronic
chr8:116560676(-) A-I      intronic
chr8:116536653(-) A-I      intronic
chr8:116536658(-) A-I      intronic
chr8:116536672(-) A-I      intronic
chr8:116481354(-) A-I      intronic
chr8:116623249(-) A-I      intronic
chr8:116468183(-) A-I      intronic
chr8:116471371(-) A-I      intronic
chr8:116536685(-) A-I      intronic
chr8:116536686(-) A-I      intronic
chr8:116536694(-) A-I      intronic
chr8:116536712(-) A-I      intronic
chr8:116651969(-) A-I      intronic
chr8:116651944(-) A-I      intronic
chr8:116471375(-) A-I      intronic
chr8:116471397(-) A-I      intronic
chr8:116651932(-) A-I      intronic
chr8:116651813(-) A-I      intronic
chr8:116560192(-) A-I      intronic
chr8:116471406(-) A-I      intronic
chr8:116481306(-) A-I      intronic
chr8:116481282(-) A-I      intronic
chr8:116481215(-) A-I      intronic
chr8:116536721(-) A-I      intronic
chr8:116536727(-) A-I      intronic
chr8:116512319(-) A-I      intronic
chr8:116536751(-) A-I      intronic
chr8:116500816(-) A-I      intronic
chr8:116500815(-) A-I      intronic
chr8:116538373(-) A-I      intronic
chr8:116481196(-) A-I      intronic
chr8:116538404(-) A-I      intronic
chr8:116560214(-) A-I      intronic
chr8:116560415(-) A-I      intronic
chr8:116512929(-) A-I      intronic
chr8:116569366(-) A-I      intronic
chr8:116481292(-) A-I      intronic
chr8:116512925(-) A-I      intronic
chr8:116481175(-) A-I      intronic
chr8:116465428(-) A-I      intronic
chr8:116560201(-) A-I      intronic
chr8:116538484(-) A-I      intronic
chr8:116651546(-) A-I      intronic
chr8:116652050(-) A-I      intronic
chr8:116538370(-) A-I      intronic
chr8:116510510(-) A-I      intronic
chr8:116560425(-) A-I      intronic
chr8:116434715(-) A-I      intronic
chr8:116512385(-) A-I      intronic
chr8:116538453(-) A-I      intronic
chr8:116652070(-) A-I      intronic
chr8:116512439(-) A-I      intronic
chr8:116538436(-) A-I      intronic
chr8:116510378(-) A-I      intronic
chr8:116510482(-) A-I      intronic
chr8:116652042(-) A-I      intronic
chr8:116471488(-) A-I      intronic
chr8:116510572(-) A-I      intronic
chr8:116512368(-) A-I      intronic
chr8:116536608(-) A-I      intronic
chr8:116512460(-) A-I      intronic
chr8:116560801(-) A-I      intronic
chr8:116560784(-) A-I      intronic
chr8:116538424(-) A-I      intronic
chr8:116512527(-) A-I      intronic
chr8:116651575(-) A-I      intronic
chr8:116538454(-) A-I      intronic
chr8:116651552(-) A-I      intronic
chr8:116512304(-) A-I      intronic
chr8:116651499(-) A-I      intronic
chr8:116560785(-) A-I      intronic
chr8:116465417(-) A-I      intronic
chr8:116505715(-) A-I      intronic
chr8:116652066(-) A-I      intronic
chr8:116560213(-) A-I      intronic
chr8:116513006(-) A-I      intronic
chr8:116512394(-) A-I      intronic
chr8:116560378(-) A-I      intronic
chr8:116512534(-) A-I      intronic
chr8:116512435(-) A-I      intronic
chr8:116512299(-) A-I      intronic
chr8:116560414(-) A-I      intronic
chr8:116468284(-) A-I      intronic
chr8:116560339(-) A-I      intronic
chr8:116538414(-) A-I      intronic
chr8:116468073(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TRPS1
chr8:116471443(-) A-I intron -    21960545
chr8:116481200(-) A-I intron -    21960545
chr8:116481282(-) A-I intron -    21960545
chr8:116505079(-) A-I intron -    21960545
chr8:116505714(-) A-I intron -    21960545
chr8:116512248(-) A-I intron -    21960545
chr8:116512299(-) A-I intron -    21960545
chr8:116538424(-) A-I intron -    21960545
chr8:116546715(-) A-I intron -    21960545
chr8:116560414(-) A-I intron -    21960545
chr8:116560452(-) A-I intron -    21960545
chr8:116560702(-) A-I intron -    21960545
chr8:116569225(-) A-I intron -    21960545
chr8:116569226(-) A-I intron -    21960545
chr8:116569292(-) A-I intron -    21960545
chr8:116569293(-) A-I intron -    21960545
chr8:116569366(-) A-I intron -    21960545
chr8:116569639(-) A-I intron -    21960545
chr8:116569649(-) A-I intron -    21960545
chr8:116569752(-) A-I intron -    21960545
chr8:116569759(-) A-I intron -    21960545
chr8:116569760(-) A-I intron -    21960545
chr8:116569830(-) A-I intron -    21960545
chr8:116569905(-) A-I intron -    21960545
chr8:116569928(-) A-I intron -    21960545
chr8:116569950(-) A-I intron -    21960545
chr8:116604699(-) A-I intron -    21960545
chr8:116604738(-) A-I intron -    21960545
chr8:116651320(-) A-I intron -    21960545
chr8:116651321(-) A-I intron -    21960545
chr8:116652042(-) A-I intron -    21960545
chr8:116652066(-) A-I intron -    21960545
chr8:116652070(-) A-I intron -    21960545
chr8:116657924(-) A-I intron -    21960545
chr8:116657965(-) A-I intron -    21960545
chr8:116569639(-) A-G intron -    22484847
chr8:116569649(-) A-G intron -    22484847
chr8:116569760(-) A-G intron -    22484847
chr8:116569775(-) A-G intron -    22484847
chr8:116569950(-) A-G intron -    22484847
chr8:116468073(-) A-G intron -    22484847
chr8:116481175(-) A-G intron -    22484847
chr8:116505715(-) A-G intron -    22484847
chr8:116512299(-) A-G intron -    22484847
chr8:116536608(-) A-G intron -    22484847
chr8:116538370(-) A-G intron -    22484847
chr8:116538414(-) A-G intron -    22484847
chr8:116538436(-) A-G intron -    22484847
chr8:116560201(-) A-G intron -    22484847
chr8:116560213(-) A-G intron -    22484847
chr8:116560378(-) A-G intron -    22484847
chr8:116560702(-) A-G intron -    22484847
chr8:116560784(-) A-G intron -    22484847
chr8:116560785(-) A-G intron -    22484847
chr8:116651321(-) A-G intron -    22484847
chr8:116651442(-) A-G intron -    22484847
chr8:116651575(-) A-G intron -    22484847
chr8:116651979(-) A-G intron -    22484847
chr8:116652042(-) A-G intron -    22484847
chr8:116652050(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRPS1
chr8:116421044-116421045(-) m6A 3'UTR       27773535
chr8:116421069-116421070(-) m6A 3'UTR       27773535
chr8:116421092-116421093(-) m6A 3'UTR       27773535
chr8:116421181-116421182(-) m6A 3'UTR       27773535
chr8:116424772-116424773(-) m6A 3'UTR       27773535//22608085
chr8:116424790-116424791(-) m6A 3'UTR       27773535//22608085
chr8:116424919-116424920(-) m6A 3'UTR       27773535//22608085
chr8:116426032-116426033(-) m6A 3'UTR       27773535
chr8:116426172-116426173(-) m6A 3'UTR       27773535//22608085
chr8:116426248-116426249(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:116426262-116426263(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr8:116426290-116426291(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27773536//22575960//22608085
chr8:116426335-116426336(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr8:116426373-116426374(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr8:116426460-116426461(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:116426492-116426493(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:116426580-116426581(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116426620-116426621(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116426677-116426678(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116426808-116426809(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116426868-116426869(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116426877-116426878(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116427023-116427024(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr8:116427201-116427202(-) m6A CDS       24284625//24981863//27773535//22608085
chr8:116427251-116427252(-) m6A CDS       24981863//27773535
chr8:116427280-116427281(-) m6A CDS       24981863//27773535
chr8:116427285-116427286(-) m6A CDS       24981863//27773535
chr8:116427295-116427296(-) m6A CDS       24981863//27773535
chr8:116430631-116430632(-) m6A CDS       27773535
chr8:116527457-116527458(-) m6A 3'UTR//intron       24284625
chr8:116599261-116599262(-) m6A CDS       24284625//22608085
chr8:116599343-116599344(-) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr8:116599412-116599413(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773536//22575960//22608085
chr8:116599418-116599419(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773536//22575960//22608085
chr8:116599495-116599496(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr8:116599544-116599545(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr8:116599630-116599631(-) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr8:116599729-116599730(-) m6A CDS       24284625//24981863//27773535//22608085
chr8:116599734-116599735(-) m6A CDS       24284625//24981863//27773535//22608085
chr8:116616200-116616201(-) Am CDS       -
chr8:116616446-116616447(-) m6A CDS//intron       24284625//24209618//22608085
chr8:116616470-116616471(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr8:116616630-116616631(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:116616664-116616665(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:116616676-116616677(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr8:116616797-116616798(-) m6A CDS//intron       24284625//22608085
chr8:116616806-116616807(-) m6A CDS//intron       24284625//22608085
chr8:116616884-116616885(-) m6A CDS       24284625//24981863//22608085
chr8:116616960-116616961(-) m6A CDS       24284625//24981863//22608085
chr8:116616978-116616979(-) m6A CDS       24284625//24981863//22608085
chr8:116617023-116617024(-) m6A CDS       24284625//24981863//22608085
chr8:116617037-116617038(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116617077-116617078(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116617087-116617088(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116617103-116617104(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:116617170-116617171(-) m6A CDS       24284625//24981863//27773535//22608085
chr8:116617189-116617190(-) m6A CDS       24284625//27773535//22608085
chr8:116617213-116617214(-) m6A CDS       24284625//27773535//22608085
chr8:116631372-116631373(-) m6A CDS       24284625//27773535//22608085
chr8:116631407-116631408(-) m6A CDS       24284625//24981863//22608085
chr8:116631452-116631453(-) m6A CDS       24284625//24981863//22608085
chr8:116631503-116631504(-) m6A CDS       24284625//24981863//22575960//22608085
chr8:116631538-116631539(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr8:116631623-116631624(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116631653-116631654(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116631681-116631682(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116631697-116631698(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116631728-116631729(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:116631795-116631796(-) m6A CDS       24284625//24981863//27773535//22608085
chr8:116631830-116631831(-) Am CDS       -
chr8:116631837-116631838(-) m6A CDS       24284625//24981863//22608085
chr8:116631848-116631849(-) m6A CDS       24284625//24981863//22608085
chr8:116631965-116631966(-) m6A CDS//intron       24284625//24981863//22608085
chr8:116631998-116631999(-) m6A CDS//intron       24284625//24981863//22608085
chr8:116632064-116632065(-) m6A CDS//intron       24981863//22608085
chr8:116632108-116632109(-) m6A CDS       24981863//22608085
chr8:116632126-116632127(-) m6A CDS       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TRPS1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: TRPS1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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