Basic Information:

  VIRBase ID:  

HHID00010197

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          TCTA:  NM_022171     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	TCTA
miRBase Accession/Entrez ID	MIMAT0004588	6988
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TCTA	chr3:49451887(+) A-I      intronic chr3:49451847(+) A-I      intronic chr3:49451846(+) A-I      intronic chr3:49451728(+) A-I      intronic chr3:49451820(+) A-I      intronic chr3:49451768(+) A-I      intronic chr3:49451742(+) A-I      intronic chr3:49452858(+) A-I      3'UTR chr3:49452877(+) A-I      3'UTR chr3:49452931(+) A-I      3'UTR chr3:49452761(+) A-I      3'UTR chr3:49452758(+) A-I      3'UTR chr3:49452790(+) A-I      3'UTR chr3:49452793(+) A-I      3'UTR chr3:49452798(+) A-I      3'UTR chr3:49452799(+) A-I      3'UTR chr3:49452822(+) A-I      3'UTR chr3:49452834(+) A-I      3'UTR chr3:49452795(+) A-I      3'UTR chr3:49452825(+) A-I      3'UTR chr3:49452890(+) A-I      3'UTR chr3:49452901(+) A-I      3'UTR chr3:49452928(+) A-I      3'UTR chr3:49452762(+) A-I      3'UTR chr3:49452738(+) A-I      3'UTR chr3:49452752(+) A-I      3'UTR chr3:49452701(+) A-I      3'UTR chr3:49452686(+) A-I      3'UTR chr3:49452764(+) A-I      3'UTR chr3:49452772(+) A-I      3'UTR chr3:49452773(+) A-I      3'UTR chr3:49452789(+) A-I      3'UTR chr3:49452784(+) A-I      3'UTR chr3:49452787(+) A-I      3'UTR chr3:49452818(+) A-I      3'UTR chr3:49452788(+) A-I      3'UTR chr3:49452721(+) A-I      3'UTR chr3:49452953(+) A-I      3'UTR chr3:49452855(+) A-I      3'UTR chr3:49452828(+) A-I      3'UTR chr3:49452802(+) A-I      3'UTR chr3:49452929(+) A-I      3'UTR chr3:49452898(+) A-I      3'UTR chr3:49452796(+) A-I      3'UTR chr3:49452936(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TCTA	chr3:49452672(+) A-G intron -    22484847 chr3:49452695(+) A-G intron -    22484847 chr3:49452787(+) A-G intron -    22484847 chr3:49452788(+) A-G intron -    22484847 chr3:49452802(+) A-G intron -    22484847 chr3:49452818(+) A-G intron -    22484847 chr3:49452829(+) A-G intron -    22484847 chr3:49452852(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TCTA	chr3:49449798-49449799(+) m6A 5'UTR//exon       24981863 chr3:49449820-49449821(+) m6A 5'UTR//exon       24981863 chr3:49449956-49449957(+) m6A CDS//exon       24284625//24981863 chr3:49452369-49452370(+) m6A 3'UTR//exon       24284625 chr3:49452378-49452379(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	TCTA	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: TCTA

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).