Basic Information:

  VIRBase ID:  

HHID00010174

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          SPAST:  NM_014946     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	SPAST
miRBase Accession/Entrez ID	MIMAT0004588	6683
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADPSP//FSP2//SPG4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SPAST	chr2:32294050(+) A-I      intronic chr2:32294040(+) A-I      intronic chr2:32291883(+) A-I      intronic chr2:32291884(+) A-I      intronic chr2:32291896(+) A-I      intronic chr2:32291900(+) A-I      intronic chr2:32294024(+) A-I      intronic chr2:32294029(+) A-I      intronic chr2:32323440(+) A-I      intronic chr2:32323446(+) A-I      intronic chr2:32357257(+) A-I      intronic chr2:32357258(+) A-I      intronic chr2:32357260(+) A-I      intronic chr2:32357297(+) A-I      intronic chr2:32357306(+) A-I      intronic chr2:32376740(+) A-I      intronic chr2:32376750(+) A-I      intronic chr2:32376803(+) A-I      intronic chr2:32359844(+) A-I      intronic chr2:32359965(+) A-I      intronic chr2:32359948(+) A-I      intronic chr2:32308089(+) A-I      intronic chr2:32309359(+) A-I      intronic chr2:32309366(+) A-I      intronic chr2:32309424(+) A-I      intronic chr2:32309432(+) A-I      intronic chr2:32309440(+) A-I      intronic chr2:32309768(+) A-I      intronic chr2:32309769(+) A-I      intronic chr2:32309835(+) A-I      intronic chr2:32309836(+) A-I      intronic chr2:32311031(+) A-I      intronic chr2:32311035(+) A-I      intronic chr2:32313033(+) A-I      intronic chr2:32313657(+) A-I      intronic chr2:32314962(+) A-I      intronic chr2:32314972(+) A-I      intronic chr2:32315024(+) A-I      intronic chr2:32316782(+) A-I      intronic chr2:32317949(+) A-I      intronic chr2:32317955(+) A-I      intronic chr2:32317956(+) A-I      intronic chr2:32359939(+) A-I      intronic chr2:32359858(+) A-I      intronic chr2:32359480(+) A-I      intronic chr2:32303473(+) A-I      intronic chr2:32300420(+) A-I      intronic chr2:32378890(+) A-I      intronic chr2:32300314(+) A-I      intronic chr2:32300319(+) A-I      intronic chr2:32300329(+) A-I      intronic chr2:32300330(+) A-I      intronic chr2:32300331(+) A-I      intronic chr2:32300401(+) A-I      intronic chr2:32317969(+) A-I      intronic chr2:32318001(+) A-I      intronic chr2:32318026(+) A-I      intronic chr2:32318483(+) A-I      intronic chr2:32319336(+) A-I      intronic chr2:32319949(+) A-I      intronic chr2:32322849(+) A-I      intronic chr2:32322863(+) A-I      intronic chr2:32322880(+) A-I      intronic chr2:32322889(+) A-I      intronic chr2:32323019(+) A-I      intronic chr2:32323456(+) A-I      intronic chr2:32323480(+) A-I      intronic chr2:32341635(+) A-I      intronic chr2:32341916(+) A-I      intronic chr2:32341943(+) A-I      intronic chr2:32341948(+) A-I      intronic chr2:32347449(+) A-I      intronic chr2:32347494(+) A-I      intronic chr2:32354396(+) A-I      intronic chr2:32354397(+) A-I      intronic chr2:32354941(+) A-I      intronic chr2:32356831(+) A-I      intronic chr2:32356832(+) A-I      intronic chr2:32356877(+) A-I      intronic chr2:32356991(+) A-I      intronic chr2:32357225(+) A-I      intronic chr2:32357230(+) A-I      intronic chr2:32359125(+) A-I      intronic chr2:32359217(+) A-I      intronic chr2:32359343(+) A-I      intronic chr2:32359845(+) A-I      intronic chr2:32306785(+) A-I      intronic chr2:32303612(+) A-I      intronic chr2:32303983(+) A-I      intronic chr2:32303986(+) A-I      intronic chr2:32304048(+) A-I      intronic chr2:32305925(+) A-I      intronic chr2:32305933(+) A-I      intronic chr2:32307618(+) A-I      intronic chr2:32360008(+) A-I      intronic chr2:32360025(+) A-I      intronic chr2:32360027(+) A-I      intronic chr2:32360039(+) A-I      intronic chr2:32360316(+) A-I      intronic chr2:32360383(+) A-I      intronic chr2:32360405(+) A-I      intronic chr2:32306810(+) A-I      intronic chr2:32307189(+) A-I      intronic chr2:32307217(+) A-I      intronic chr2:32307223(+) A-I      intronic chr2:32307551(+) A-I      intronic chr2:32307556(+) A-I      intronic chr2:32307614(+) A-I      intronic chr2:32360450(+) A-I      intronic chr2:32360458(+) A-I      intronic chr2:32360788(+) A-I      intronic chr2:32369802(+) A-I      intronic chr2:32369815(+) A-I      intronic chr2:32371442(+) A-I      intronic chr2:32371446(+) A-I      intronic chr2:32371536(+) A-I      intronic chr2:32372491(+) A-I      intronic chr2:32291536(+) A-I      intronic chr2:32291572(+) A-I      intronic chr2:32300304(+) A-I      intronic chr2:32294835(+) A-I      intronic chr2:32293184(+) A-I      intronic chr2:32292393(+) A-I      intronic chr2:32291968(+) A-I      intronic chr2:32291788(+) A-I      intronic chr2:32291787(+) A-I      intronic chr2:32291644(+) A-I      intronic chr2:32291626(+) A-I      intronic chr2:32291578(+) A-I      intronic chr2:32379052(+) A-I      intronic chr2:32291484(+) A-I      intronic chr2:32372732(+) A-I      intronic chr2:32372770(+) A-I      intronic chr2:32372830(+) A-I      intronic chr2:32372840(+) A-I      intronic chr2:32372952(+) A-I      intronic chr2:32373809(+) A-I      intronic chr2:32374178(+) A-I      intronic chr2:32374223(+) A-I      intronic chr2:32374245(+) A-I      intronic chr2:32375421(+) A-I      intronic chr2:32375652(+) A-I      intronic chr2:32376783(+) A-I      intronic chr2:32377441(+) A-I      intronic chr2:32377453(+) A-I      intronic chr2:32377848(+) A-I      intronic chr2:32378582(+) A-I      intronic chr2:32378436(+) A-I      intronic chr2:32376995(+) A-I      intronic chr2:32356861(+) A-I      intronic chr2:32376859(+) A-I      intronic chr2:32354810(+) A-I      intronic chr2:32379026(+) A-I      intronic chr2:32318025(+) A-I      intronic chr2:32376209(+) A-I      intronic chr2:32368276(+) A-I      intronic chr2:32347410(+) A-I      intronic chr2:32318495(+) A-I      intronic chr2:32300237(+) A-I      intronic chr2:32377558(+) A-I      intronic chr2:32291769(+) A-I      intronic chr2:32373759(+) A-I      intronic chr2:32359234(+) A-I      intronic chr2:32294791(+) A-I      intronic chr2:32337597(+) A-I      intronic chr2:32294120(+) A-I      intronic chr2:32361081(+) A-I      intronic chr2:32376153(+) A-I      intronic chr2:32321446(+) A-I      intronic chr2:32341562(+) A-I      intronic chr2:32321318(+) A-I      intronic chr2:32304331(+) A-I      intronic chr2:32294131(+) A-I      intronic chr2:32322952(+) A-I      intronic chr2:32307242(+) A-I      intronic chr2:32364919(+) A-I      intronic chr2:32361049(+) A-I      intronic chr2:32304499(+) A-I      intronic chr2:32375538(+) A-I      intronic chr2:32310360(+) A-I      intronic chr2:32291932(+) A-I      intronic chr2:32303519(+) A-I      intronic chr2:32304433(+) A-I      intronic chr2:32338406(+) A-I      intronic chr2:32372542(+) A-I      intronic chr2:32341596(+) A-I      intronic chr2:32294130(+) A-I      intronic chr2:32378052(+) A-I      intronic chr2:32367726(+) A-I      intronic chr2:32355014(+) A-I      intronic chr2:32375593(+) A-I      intronic chr2:32368222(+) A-I      intronic chr2:32376707(+) A-I      intronic chr2:32367613(+) A-I      intronic chr2:32357313(+) A-I      intronic chr2:32376937(+) A-I      intronic chr2:32294237(+) A-I      intronic chr2:32341890(+) A-I      intronic chr2:32379055(+) A-I      intronic chr2:32299600(+) A-I      intronic chr2:32372492(+) A-I      intronic chr2:32323410(+) A-I      intronic chr2:32377545(+) A-I      intronic chr2:32377451(+) A-I      intronic chr2:32291700(+) A-I      intronic chr2:32300374(+) A-I      intronic chr2:32357204(+) A-I      intronic chr2:32311410(+) A-I      intronic chr2:32294121(+) A-I      intronic chr2:32347484(+) A-I      intronic chr2:32381388(+) A-I      3'UTR chr2:32377571(+) A-I      intronic chr2:32315018(+) A-I      intronic chr2:32303598(+) A-I      intronic chr2:32323279(+) A-I      intronic chr2:32361027(+) A-I      intronic chr2:32300758(+) A-I      intronic chr2:32372569(+) A-I      intronic chr2:32376969(+) A-I      intronic chr2:32321365(+) A-I      intronic chr2:32377381(+) A-I      intronic chr2:32304728(+) A-I      intronic chr2:32293460(+) A-I      intronic chr2:32300236(+) A-I      intronic chr2:32291906(+) A-I      intronic chr2:32355532(+) A-I      intronic chr2:32371814(+) A-I      intronic chr2:32291112(+) A-I      intronic chr2:32376801(+) A-I      intronic chr2:32353338(+) A-I      intronic chr2:32377379(+) A-I      intronic chr2:32378891(+) A-I      intronic chr2:32316543(+) A-I      intronic chr2:32373222(+) A-I      intronic chr2:32353326(+) A-I      intronic chr2:32291861(+) A-I      intronic chr2:32292187(+) A-I      intronic chr2:32302982(+) A-I      intronic chr2:32291528(+) A-I      intronic chr2:32291305(+) A-I      intronic chr2:32291224(+) A-I      intronic chr2:32293582(+) A-I      intronic chr2:32304384(+) A-I      intronic chr2:32377431(+) A-I      intronic chr2:32339113(+) A-I      intronic chr2:32371846(+) A-I      intronic chr2:32357356(+) A-I      intronic chr2:32303454(+) A-I      intronic chr2:32379054(+) A-I      intronic chr2:32293888(+) A-I      intronic chr2:32309264(+) A-I      intronic chr2:32304322(+) A-I      intronic chr2:32379067(+) A-I      intronic chr2:32359424(+) A-I      intronic chr2:32316546(+) A-I      intronic chr2:32378882(+) A-I      intronic chr2:32341804(+) A-I      intronic chr2:32323041(+) A-I      intronic chr2:32300361(+) A-I      intronic chr2:32316450(+) A-I      intronic chr2:32304434(+) A-I      intronic chr2:32306370(+) A-I      intronic chr2:32293966(+) A-I      intronic chr2:32368191(+) A-I      intronic chr2:32342701(+) A-I      intronic chr2:32291958(+) A-I      intronic chr2:32310855(+) A-I      intronic chr2:32319924(+) A-I      intronic chr2:32374259(+) A-I      intronic chr2:32355641(+) A-I      intronic chr2:32378944(+) A-I      intronic chr2:32378039(+) A-I      intronic chr2:32299645(+) A-I      intronic chr2:32307133(+) A-I      intronic chr2:32368190(+) A-I      intronic chr2:32304437(+) A-I      intronic chr2:32375646(+) A-I      intronic chr2:32367727(+) A-I      intronic chr2:32359641(+) A-I      intronic chr2:32376715(+) A-I      intronic chr2:32342848(+) A-I      intronic chr2:32322892(+) A-I      intronic chr2:32299776(+) A-I      intronic chr2:32368077(+) A-I      intronic chr2:32378951(+) A-I      intronic chr2:32378000(+) A-I      intronic chr2:32356897(+) A-I      intronic chr2:32370230(+) A-I      intronic chr2:32313337(+) A-I      intronic chr2:32357226(+) A-I      intronic chr2:32368086(+) A-I      intronic chr2:32341636(+) A-I      intronic chr2:32359877(+) A-I      intronic chr2:32377581(+) A-I      intronic chr2:32311362(+) A-I      intronic chr2:32347414(+) A-I      intronic chr2:32323445(+) A-I      intronic chr2:32311576(+) A-I      intronic chr2:32375765(+) A-I      intronic chr2:32379025(+) A-I      intronic chr2:32375690(+) A-I      intronic chr2:32303507(+) A-I      intronic chr2:32377896(+) A-I      intronic chr2:32371840(+) A-I      intronic chr2:32302947(+) A-I      intronic chr2:32311384(+) A-I      intronic chr2:32376802(+) A-I      intronic chr2:32306732(+) A-I      intronic chr2:32360807(+) A-I      intronic chr2:32292311(+) A-I      intronic chr2:32293661(+) A-I      intronic chr2:32302988(+) A-I      intronic chr2:32293615(+) A-I      intronic chr2:32359477(+) A-I      intronic chr2:32342211(+) A-I      intronic chr2:32347412(+) A-I      intronic chr2:32347605(+) A-I      intronic chr2:32319344(+) A-I      intronic chr2:32361026(+) A-I      intronic chr2:32310324(+) A-I      intronic chr2:32303982(+) A-I      intronic chr2:32292392(+) A-I      intronic chr2:32293558(+) A-I      intronic chr2:32360968(+) A-I      intronic chr2:32321384(+) A-I      intronic chr2:32357479(+) A-I      intronic chr2:32319324(+) A-I      intronic chr2:32323353(+) A-I      intronic chr2:32376759(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SPAST	chr2:32294120(+) A-I intron -    22028664 chr2:32294121(+) A-I intron -    22028664 chr2:32294130(+) A-I intron -    22028664 chr2:32294131(+) A-I intron -    22028664 chr2:32294135(+) A-I intron -    22028664 chr2:32291528(+) A-G intron -    22484847 chr2:32292231(+) A-G intron -    22484847 chr2:32293460(+) A-G intron -    22484847 chr2:32293558(+) A-G intron -    22484847 chr2:32293582(+) A-G intron -    22484847 chr2:32294637(+) C-T intron -    22484847 chr2:32294695(+) A-G intron -    22484847 chr2:32294791(+) A-G intron -    22484847 chr2:32299645(+) A-G intron -    22484847 chr2:32299776(+) A-G intron -    22484847 chr2:32300236(+) A-G intron -    22484847 chr2:32300237(+) A-G intron -    22484847 chr2:32300361(+) A-G intron -    22484847 chr2:32300374(+) A-G intron -    22484847 chr2:32303454(+) A-G intron -    22484847 chr2:32304433(+) A-G intron -    22484847 chr2:32304434(+) A-G intron -    22484847 chr2:32304437(+) A-G intron -    22484847 chr2:32304499(+) A-G intron -    22484847 chr2:32304727(+) A-G intron -    22484847 chr2:32304728(+) A-G intron -    22484847 chr2:32306370(+) A-G intron -    22484847 chr2:32307671(+) A-G intron -    22484847 chr2:32309264(+) A-G intron -    22484847 chr2:32310855(+) A-G intron -    22484847 chr2:32311384(+) A-G intron -    22484847 chr2:32311410(+) A-G intron -    22484847 chr2:32313192(+) A-G intron -    22484847 chr2:32316450(+) A-G intron -    22484847 chr2:32316483(+) A-G intron -    22484847 chr2:32316543(+) A-G intron -    22484847 chr2:32316546(+) A-G intron -    22484847 chr2:32318495(+) A-G intron -    22484847 chr2:32319362(+) A-G intron -    22484847 chr2:32322892(+) A-G intron -    22484847 chr2:32322902(+) A-G intron -    22484847 chr2:32322958(+) A-G intron -    22484847 chr2:32323280(+) A-G intron -    22484847 chr2:32323410(+) A-G intron -    22484847 chr2:32323445(+) A-G intron -    22484847 chr2:32340121(+) G-A intron -    22484847 chr2:32341596(+) A-G intron -    22484847 chr2:32341604(+) A-G intron -    22484847 chr2:32341636(+) A-G intron -    22484847 chr2:32341662(+) A-G intron -    22484847 chr2:32341804(+) A-G intron -    22484847 chr2:32341923(+) A-G intron -    22484847 chr2:32341926(+) A-G intron -    22484847 chr2:32347484(+) A-G intron -    22484847 chr2:32347605(+) A-G intron -    22484847 chr2:32347751(+) A-G intron -    22484847 chr2:32350358(+) T-C intron -    22484847 chr2:32359477(+) A-G intron -    22484847 chr2:32359814(+) A-G intron -    22484847 chr2:32359877(+) A-G intron -    22484847 chr2:32360789(+) A-G intron -    22484847 chr2:32360980(+) T-C intron -    22484847 chr2:32367613(+) A-G intron -    22484847 chr2:32367689(+) A-G intron -    22484847 chr2:32368077(+) A-G intron -    22484847 chr2:32368086(+) A-G intron -    22484847 chr2:32368190(+) A-G intron -    22484847 chr2:32368251(+) T-C intron -    22484847 chr2:32368277(+) T-C intron -    22484847 chr2:32370317(+) T-C intron -    22484847 chr2:32371749(+) T-C intron -    22484847 chr2:32372569(+) A-G intron -    22484847 chr2:32372827(+) A-G intron -    22484847 chr2:32375593(+) A-G intron -    22484847 chr2:32375646(+) A-G intron -    22484847 chr2:32376715(+) A-G intron -    22484847 chr2:32377581(+) A-G intron -    22484847 chr2:32378891(+) A-G intron -    22484847 chr2:32378944(+) A-G intron -    22484847 chr2:32378951(+) A-G intron -    22484847 chr2:32378970(+) A-G intron -    22484847 chr2:32379025(+) A-G intron -    22484847 chr2:32379026(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPAST	chr2:32288784-32288785(+) m6A 5'UTR       25456834//24981863 chr2:32288927-32288928(+) m1A CDS       26863196//26863410 chr2:32372293-32372294(+) m6A CDS       24284625 chr2:32372299-32372300(+) m6A CDS       24284625//24981863 chr2:32379511-32379512(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr2:32379536-32379537(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr2:32379542-32379543(+) m6A CDS       24284625//24209618//24981863//26404942//22608085 chr2:32379581-32379582(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379590-32379591(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379611-32379612(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379647-32379648(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379665-32379666(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379697-32379698(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379709-32379710(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379717-32379718(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379727-32379728(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr2:32379800-32379801(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr2:32379823-32379824(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr2:32379907-32379908(+) m6A 3'UTR       26404942 chr2:32382217-32382218(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SPAST	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: SPAST

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).