Detail Information

Basic Information:


  VIRBase ID:  

HHID00009919

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           ETS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p ETS1
miRBase
Accession/Entrez ID		 MIMAT0004588 2113
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - c-ets-1//ETS-1//EWSR2//p54

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ETS1
chr11:128440225(-) A-I      intronic
chr11:128440222(-) A-I      intronic
chr11:128440199(-) A-I      intronic
chr11:128440298(-) A-I      intronic
chr11:128440282(-) A-I      intronic
chr11:128440270(-) A-I      intronic
chr11:128440261(-) A-I      intronic
chr11:128440257(-) A-I      intronic
chr11:128440238(-) A-I      intronic
chr11:128440230(-) A-I      intronic
chr11:128437722(-) A-I      intronic
chr11:128437761(-) A-I      intronic
chr11:128437747(-) A-I      intronic
chr11:128440418(-) A-I      intronic
chr11:128437725(-) A-I      intronic
chr11:128440409(-) A-I      intronic
chr11:128437756(-) A-I      intronic
chr11:128440416(-) A-I      intronic
chr11:128437753(-) A-I      intronic
chr11:128437665(-) A-I      intronic
chr11:128437692(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ETS1
chr11:128354716(-) T-C intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ETS1
chr11:128331249-128331250(-) Gm 3'UTR       -
chr11:128331468-128331469(-) m6A 3'UTR       26404942
chr11:128331483-128331484(-) m6A 3'UTR       26404942
chr11:128331539-128331540(-) m6A 3'UTR       26404942//27773535
chr11:128331552-128331553(-) m6A 3'UTR       26404942//27773535
chr11:128331704-128331705(-) m6A 3'UTR       24284625//24981863//26404942//27773535
chr11:128331726-128331727(-) m6A 3'UTR       24284625//24981863//28052920//26404942//27773535
chr11:128331764-128331765(-) m6A 3'UTR       24284625//24981863//28052920//26404942//27773535
chr11:128331800-128331801(-) m6A 3'UTR       24981863//26404942//27773535
chr11:128331871-128331872(-) m6A 3'UTR       24209618//24981863//26404942//27773535
chr11:128331880-128331881(-) m6A 3'UTR       24209618//24981863//26404942//27773535
chr11:128331911-128331912(-) m6A 3'UTR       24209618//24981863//26404942//27773535
chr11:128331968-128331969(-) m6A 3'UTR       24209618//24981863//28052920//26404942//27773535//27371828
chr11:128332051-128332052(-) m6A 3'UTR       24209618//24981863//28052920//26404942//27773535//27371828
chr11:128332069-128332070(-) m6A 3'UTR       24209618//24981863//28052920//26404942//27773535//27371828
chr11:128332151-128332152(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828
chr11:128332193-128332194(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr11:128332210-128332211(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828
chr11:128332221-128332222(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960
chr11:128332232-128332233(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960
chr11:128332368-128332369(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr11:128332382-128332383(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr11:128332417-128332418(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535
chr11:128332442-128332443(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535
chr11:128333421-128333422(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535
chr11:128333444-128333445(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535
chr11:128350126-128350127(-) m6A CDS//intron       24284625//26404942
chr11:128350147-128350148(-) m6A CDS//intron       24284625//26404942
chr11:128350159-128350160(-) m6A CDS//intron       24284625//26404942
chr11:128350207-128350208(-) m6A CDS//intron       24284625//26404942
chr11:128354726-128354727(-) m6A CDS//intron       27773535
chr11:128354746-128354747(-) m6A CDS//intron       27773535
chr11:128354766-128354767(-) m6A CDS//intron       27773535
chr11:128354801-128354802(-) m6A CDS//intron       27773535
chr11:128354812-128354813(-) m6A CDS//intron       27773535
chr11:128391926-128391927(-) m6A 5'UTR//intron       24284625//24209618//28052920//26404942//27371828
chr11:128391942-128391943(-) m6A 5'UTR//intron       24284625//24209618//28052920//26404942//27371828
chr11:128392111-128392112(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ETS1
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: ETS1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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