Basic Information:

  VIRBase ID:  

HHID00009912

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          EIF4G1:  NM_001194947     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	EIF4G1
miRBase Accession/Entrez ID	MIMAT0004588	1981
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EIF-4G1//EIF4F//EIF4G//EIF4GI//P220//PARK18

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF4G1	chr3:184036782(+) A-I      intronic chr3:184048645(+) A-I      intronic chr3:184047243(+) A-I      intronic chr3:184047381(+) A-I      intronic chr3:184036812(+) A-I      intronic chr3:184048052(+) A-I      intronic chr3:184048154(+) A-I      intronic chr3:184048669(+) A-I      intronic chr3:184048673(+) A-I      intronic chr3:184048702(+) A-I      intronic chr3:184036615(+) A-I      intronic chr3:184036456(+) A-I      intronic chr3:184036747(+) A-I      intronic chr3:184036751(+) A-I      intronic chr3:184047965(+) A-I      intronic chr3:184042515(+) A-I      intronic chr3:184036764(+) A-I      intronic chr3:184047286(+) A-I      intronic chr3:184036492(+) A-I      intronic chr3:184048046(+) A-I      intronic chr3:184036290(+) A-I      intronic chr3:184036493(+) A-I      intronic chr3:184047915(+) A-I      intronic chr3:184036189(+) A-I      intronic chr3:184036156(+) A-I      intronic chr3:184036573(+) A-I      intronic chr3:184036807(+) A-I      intronic chr3:184047989(+) A-I      intronic chr3:184047166(+) A-I      intronic chr3:184048111(+) A-I      intronic chr3:184036412(+) A-I      intronic chr3:184048796(+) A-I      intronic chr3:184048667(+) A-I      intronic chr3:184036284(+) A-I      intronic chr3:184036798(+) A-I      intronic chr3:184036510(+) A-I      intronic chr3:184036783(+) A-I      intronic chr3:184036654(+) A-I      intronic chr3:184036742(+) A-I      intronic chr3:184048003(+) A-I      intronic chr3:184036223(+) A-I      intronic chr3:184036741(+) A-I      intronic chr3:184036715(+) A-I      intronic chr3:184036808(+) A-I      intronic chr3:184048112(+) A-I      intronic chr3:184047258(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF4G1	chr3:184036189(+) A-G intron -    22484847 chr3:184036306(+) A-G intron -    22484847 chr3:184036412(+) A-G intron -    22484847 chr3:184036472(+) A-G intron -    22484847 chr3:184036493(+) A-G intron -    22484847 chr3:184036510(+) A-G intron -    22484847 chr3:184036719(+) A-G intron -    22484847 chr3:184036741(+) A-G intron -    22484847 chr3:184036764(+) A-G intron -    22484847 chr3:184036807(+) A-G intron -    22484847 chr3:184036808(+) A-G intron -    22484847 chr3:184042515(+) A-G intron -    22484847 chr3:184042519(+) A-C intron -    22484847 chr3:184047931(+) G-T intron -    22484847 chr3:184047965(+) A-G intron -    22484847 chr3:184048667(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF4G1	chr3:184032407-184032408(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032445-184032446(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032455-184032456(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032964-184032965(+) m6A 5'UTR//intron       24284625//25456834//24981863//22575960 chr3:184033119-184033120(+) m6A 5'UTR//intron       24284625 chr3:184033204-184033205(+) m6A 5'UTR//intron       24284625 chr3:184033293-184033294(+) m6A 5'UTR//exon//intron       24284625//22575960 chr3:184033313-184033314(+) m6A 5'UTR//exon//intron       24284625 chr3:184033561-184033562(+) m6A 5'UTR//exon//intron       24284625//24981863 chr3:184033588-184033589(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863 chr3:184033634-184033635(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863 chr3:184033683-184033684(+) m6A exon//intron       24284625//24981863 chr3:184033898-184033899(+) m6A 5'UTR//exon//intron       24284625 chr3:184033940-184033941(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184033983-184033984(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184035281-184035282(+) m6A CDS//intron       24284625//22575960 chr3:184035597-184035598(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184036999-184037000(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037005-184037006(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037010-184037011(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037026-184037027(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037548-184037549(+) m6A 3'UTR//CDS//exon//intron       24284625 chr3:184038148-184038149(+) m6A 5'UTR//intron       24284625 chr3:184038436-184038437(+) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr3:184038674-184038675(+) m6A 3'UTR//intron       24284625//22575960 chr3:184038688-184038689(+) m6A 3'UTR//intron       24284625//22575960 chr3:184039190-184039191(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184039234-184039235(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:184039290-184039291(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:184039319-184039320(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039337-184039338(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039370-184039371(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039484-184039485(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039577-184039578(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039612-184039613(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039817-184039818(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184040215-184040216(+) m6A 3'UTR//CDS       24209618//24981863//26404942//27773535//22575960 chr3:184040335-184040336(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040439-184040440(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040446-184040447(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040458-184040459(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040479-184040480(+) m6A 3'UTR//CDS       24981863//26404942//22575960 chr3:184040495-184040496(+) m6A 3'UTR//CDS       24981863//26404942//22575960 chr3:184040515-184040516(+) Cm 3'UTR//CDS       - chr3:184040626-184040627(+) m6A 3'UTR//CDS       26404942 chr3:184040737-184040738(+) m6A 3'UTR//CDS       26404942 chr3:184040879-184040880(+) m6A 3'UTR//CDS       26404942 chr3:184040908-184040909(+) m6A 3'UTR//CDS       26404942 chr3:184040934-184040935(+) m6A 3'UTR//CDS       22575960 chr3:184040966-184040967(+) m6A 3'UTR//CDS       22575960 chr3:184041206-184041207(+) m6A 3'UTR//CDS       22575960 chr3:184041227-184041228(+) m6A 3'UTR//CDS       22575960 chr3:184041239-184041240(+) m6A 3'UTR//CDS       22575960 chr3:184041246-184041247(+) Am 3'UTR//CDS       - chr3:184041284-184041285(+) m6A 3'UTR//CDS       22575960 chr3:184041289-184041290(+) m6A 3'UTR//CDS       22575960 chr3:184041311-184041312(+) m6A 3'UTR//CDS       22575960 chr3:184041355-184041356(+) m1A 3'UTR//CDS       26863410 chr3:184041375-184041376(+) m6A 3'UTR//CDS       22575960 chr3:184041602-184041603(+) m6A 3'UTR//CDS       26404942//22575960 chr3:184042028-184042029(+) m6A 3'UTR//CDS       27773535 chr3:184042034-184042035(+) Gm 3'UTR//CDS       - chr3:184042076-184042077(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042711-184042712(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042766-184042767(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042811-184042812(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042822-184042823(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042879-184042880(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042885-184042886(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184043306-184043307(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043344-184043345(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043552-184043553(+) Tm intron       - chr3:184043645-184043646(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043674-184043675(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184045038-184045039(+) Gm 3'UTR//CDS       - chr3:184045041-184045042(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045050-184045051(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045080-184045081(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045089-184045090(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045109-184045110(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960 chr3:184045218-184045219(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr3:184046447-184046448(+) m6A 3'UTR//CDS//exon       22575960 chr3:184046490-184046491(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184046580-184046581(+) m6A exon//intron       24284625//22575960 chr3:184046655-184046656(+) m6A exon//intron       24284625//22575960 chr3:184046717-184046718(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049126-184049127(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049148-184049149(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049329-184049330(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049606-184049607(+) m6A exon//intron       24284625//22575960 chr3:184049642-184049643(+) m6A exon//intron       24284625//22575960 chr3:184049687-184049688(+) m6A exon//intron       24284625//22575960 chr3:184049738-184049739(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049863-184049864(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184052578-184052579(+) Cm 3'UTR//CDS//exon       - chr3:184052598-184052599(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:184052714-184052715(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184052730-184052731(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184052759-184052760(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr3:184052819-184052820(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:184053024-184053025(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	EIF4G1	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: EIF4G1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).