Detail Information

Basic Information:


  VIRBase ID:  

HHID00009910

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           MEGF9:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p MEGF9
miRBase
Accession/Entrez ID		 MIMAT0004588 1955
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EGFL5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MEGF9
chr9:123401594(-) A-I      intronic
chr9:123401615(-) A-I      intronic
chr9:123401691(-) A-I      intronic
chr9:123440979(-) A-I      intronic
chr9:123444913(-) A-I      intronic
chr9:123400423(-) A-I      intronic
chr9:123376533(-) A-I      intronic
chr9:123378768(-) A-I      intronic
chr9:123436889(-) A-I      intronic
chr9:123445060(-) A-I      intronic
chr9:123376331(-) A-I      intronic
chr9:123469013(-) A-I      intronic
chr9:123401219(-) A-I      intronic
chr9:123432634(-) A-I      intronic
chr9:123469012(-) A-I      intronic
chr9:123386674(-) A-I      intronic
chr9:123386682(-) A-I      intronic
chr9:123386685(-) A-I      intronic
chr9:123444944(-) A-I      intronic
chr9:123399935(-) A-I      intronic
chr9:123399942(-) A-I      intronic
chr9:123445056(-) A-I      intronic
chr9:123386915(-) A-I      intronic
chr9:123386778(-) A-I      intronic
chr9:123386752(-) A-I      intronic
chr9:123412464(-) A-I      intronic
chr9:123387068(-) A-I      intronic
chr9:123401134(-) A-I      intronic
chr9:123412463(-) A-I      intronic
chr9:123406274(-) A-I      intronic
chr9:123386543(-) A-I      intronic
chr9:123444920(-) A-I      intronic
chr9:123444932(-) A-I      intronic
chr9:123437700(-) A-I      intronic
chr9:123440907(-) A-I      intronic
chr9:123437698(-) A-I      intronic
chr9:123386638(-) A-I      intronic
chr9:123437697(-) A-I      intronic
chr9:123437667(-) A-I      intronic
chr9:123399946(-) A-I      intronic
chr9:123401206(-) A-I      intronic
chr9:123457773(-) A-I      intronic
chr9:123446134(-) A-I      intronic
chr9:123386733(-) A-I      intronic
chr9:123474314(-) A-I      intronic
chr9:123391416(-) A-I      intronic
chr9:123391537(-) A-I      intronic
chr9:123392027(-) A-I      intronic
chr9:123392048(-) A-I      intronic
chr9:123392209(-) A-I      intronic
chr9:123398488(-) A-I      intronic
chr9:123398489(-) A-I      intronic
chr9:123400396(-) A-I      intronic
chr9:123406192(-) A-I      intronic
chr9:123401704(-) A-I      intronic
chr9:123468847(-) A-I      intronic
chr9:123364464(-) A-I      3'UTR
chr9:123364476(-) A-I      3'UTR
chr9:123364477(-) A-I      3'UTR
chr9:123364485(-) A-I      3'UTR
chr9:123386986(-) A-I      intronic
chr9:123437904(-) A-I      intronic
chr9:123386563(-) A-I      intronic
chr9:123391955(-) A-I      intronic
chr9:123415787(-) A-I      intronic
chr9:123400373(-) A-I      intronic
chr9:123401686(-) A-I      intronic
chr9:123448540(-) A-I      intronic
chr9:123400482(-) A-I      intronic
chr9:123398410(-) A-I      intronic
chr9:123401187(-) A-I      intronic
chr9:123446122(-) A-I      intronic
chr9:123472070(-) A-I      intronic
chr9:123376489(-) A-I      intronic
chr9:123406111(-) A-I      intronic
chr9:123391421(-) A-I      intronic
chr9:123378001(-) A-I      intronic
chr9:123364360(-) A-I      3'UTR
chr9:123364373(-) A-I      3'UTR
chr9:123364390(-) A-I      3'UTR
chr9:123364461(-) A-I      3'UTR
chr9:123440965(-) A-I      intronic
chr9:123400521(-) A-I      intronic
chr9:123386700(-) A-I      intronic
chr9:123376404(-) A-I      intronic
chr9:123412351(-) A-I      intronic
chr9:123414027(-) A-I      intronic
chr9:123376398(-) A-I      intronic
chr9:123464072(-) A-I      intronic
chr9:123376413(-) A-I      intronic
chr9:123437085(-) A-I      intronic
chr9:123386553(-) A-I      intronic
chr9:123368195(-) A-I      intronic
chr9:123399887(-) A-I      intronic
chr9:123463103(-) A-I      intronic
chr9:123436985(-) A-I      intronic
chr9:123378166(-) A-I      intronic
chr9:123438464(-) A-I      intronic
chr9:123438465(-) A-I      intronic
chr9:123434650(-) A-I      intronic
chr9:123415788(-) A-I      intronic
chr9:123401662(-) A-I      intronic
chr9:123412486(-) A-I      intronic
chr9:123386785(-) A-I      intronic
chr9:123448552(-) A-I      intronic
chr9:123400469(-) A-I      intronic
chr9:123386933(-) A-I      intronic
chr9:123391539(-) A-I      intronic
chr9:123387334(-) A-I      intronic
chr9:123440953(-) A-I      intronic
chr9:123400412(-) A-I      intronic
chr9:123459633(-) A-I      intronic
chr9:123391490(-) A-I      intronic
chr9:123400410(-) A-I      intronic
chr9:123400400(-) A-I      intronic
chr9:123378024(-) A-I      intronic
chr9:123377405(-) A-I      intronic
chr9:123401234(-) A-I      intronic
chr9:123400354(-) A-I      intronic
chr9:123387305(-) A-I      intronic
chr9:123401569(-) A-I      intronic
chr9:123368405(-) A-I      intronic
chr9:123401590(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MEGF9
chr9:123363533(-) A-I exon 3'UTR    15342557
chr9:123364205(-) A-I exon 3'UTR    15342557
chr9:123364360(-) A-I exon 3'UTR    15342557
chr9:123364373(-) A-I exon 3'UTR    15342557
chr9:123364390(-) A-I exon 3'UTR    15342557
chr9:123364416(-) A-I exon 3'UTR    15342557
chr9:123364426(-) A-I exon 3'UTR    15342557

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MEGF9
chr9:123366953-123366954(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr9:123367017-123367018(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr9:123367056-123367057(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr9:123367070-123367071(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr9:123367090-123367091(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085
chr9:123367101-123367102(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367163-123367164(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367184-123367185(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367204-123367205(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367230-123367231(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367259-123367260(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367399-123367400(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367421-123367422(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367439-123367440(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367457-123367458(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367603-123367604(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367622-123367623(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367641-123367642(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367648-123367649(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367745-123367746(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr9:123367777-123367778(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:123367805-123367806(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:123370068-123370069(-) m6A CDS       24284625//24981863//27773535
chr9:123370144-123370145(-) m6A CDS       24284625//24981863
chr9:123476122-123476123(-) m6A CDS       24284625//24981863
chr9:123476210-123476211(-) m6A CDS       24284625//27773536
chr9:123476306-123476307(-) m6A CDS       24284625//27371828//27773536
chr9:123476332-123476333(-) m6A CDS       24284625//27371828//27773536
chr9:123476398-123476399(-) m6A CDS       24284625//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MEGF9
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: MEGF9

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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