Detail Information

Basic Information:


  VIRBase ID:  

HHID00009851

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           SCARB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p SCARB2
miRBase
Accession/Entrez ID		 MIMAT0004588 950
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AMRF//CD36L2//EPM4//HLGP85//LGP85//LIMP-2//LIMPII//SR-BII

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SCARB2
chr4:77111405(-) A-I      intronic
chr4:77113040(-) A-I      intronic
chr4:77113062(-) A-I      intronic
chr4:77113068(-) A-I      intronic
chr4:77113080(-) A-I      intronic
chr4:77113103(-) A-I      intronic
chr4:77111362(-) A-I      intronic
chr4:77113905(-) A-I      intronic
chr4:77113961(-) A-I      intronic
chr4:77113972(-) A-I      intronic
chr4:77104068(-) A-I      intronic
chr4:77104052(-) A-I      intronic
chr4:77104044(-) A-I      intronic
chr4:77111381(-) A-I      intronic
chr4:77104043(-) A-I      intronic
chr4:77111359(-) A-I      intronic
chr4:77111358(-) A-I      intronic
chr4:77105878(-) A-I      intronic
chr4:77105867(-) A-I      intronic
chr4:77105866(-) A-I      intronic
chr4:77113948(-) A-I      intronic
chr4:77113923(-) A-I      intronic
chr4:77113175(-) A-I      intronic
chr4:77111861(-) A-I      intronic
chr4:77105901(-) A-I      intronic
chr4:77105872(-) A-I      intronic
chr4:77104038(-) A-I      intronic
chr4:77110867(-) A-I      intronic
chr4:77115394(-) A-I      intronic
chr4:77080712(-) A-I      3'UTR
chr4:77080695(-) A-I      3'UTR
chr4:77080692(-) A-I      3'UTR
chr4:77080683(-) A-I      3'UTR
chr4:77080642(-) A-I      3'UTR
chr4:77100433(-) A-I      intronic
chr4:77110871(-) A-I      intronic
chr4:77113197(-) A-I      intronic
chr4:77111290(-) A-I      intronic
chr4:77110752(-) A-I      intronic
chr4:77105852(-) A-I      intronic
chr4:77080860(-) A-I      3'UTR
chr4:77110732(-) A-I      intronic
chr4:77110683(-) A-I      intronic
chr4:77113191(-) A-I      intronic
chr4:77111344(-) A-I      intronic
chr4:77113196(-) A-I      intronic
chr4:77102991(-) A-I      intronic
chr4:77111438(-) A-I      intronic
chr4:77105853(-) A-I      intronic
chr4:77111395(-) A-I      intronic
chr4:77111435(-) A-I      intronic
chr4:77116511(-) A-I      intronic
chr4:77102975(-) A-I      intronic
chr4:77105928(-) A-I      intronic
chr4:77113093(-) A-I      intronic
chr4:77105927(-) A-I      intronic
chr4:77110880(-) A-I      intronic
chr4:77124260(-) A-I      intronic
chr4:77102790(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SCARB2
chr4:77080771(-) A-T exon 3'UTR    21725310
chr4:77115309(-) A-G intron -    22484847
chr4:77102991(-) A-G intron -    22484847
chr4:77103005(-) A-G intron -    22484847
chr4:77110823(-) A-G intron -    22484847
chr4:77111837(-) A-G intron -    22484847
chr4:77113889(-) A-G intron -    22484847
chr4:77113974(-) A-G intron -    22484847
chr4:77116511(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SCARB2
chr4:77082728-77082729(-) m6A 3'UTR       24981863
chr4:77082752-77082753(-) m6A 3'UTR       24981863
chr4:77082800-77082801(-) m6A 3'UTR       24981863//27371828
chr4:77082840-77082841(-) m6A 3'UTR       27371828
chr4:77134591-77134592(-) Gm CDS       -
chr4:77134828-77134829(-) m6A 5'UTR       27773536
chr4:77134921-77134922(-) m6A 5'UTR       24981863//27773536
chr4:77134927-77134928(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
SCARB2
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: SCARB2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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