Basic Information:

  VIRBase ID:  

HHID00009754

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:  MIMAT0004515          DNMT3A:  NR_135490     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-2-5p	DNMT3A
miRBase Accession/Entrez ID	MIMAT0004515	1788
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DNMT3A2//HESJAS//M.HsaIIIA//TBRS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-2-5p	rs1389711693 chr1:207802500    C/A rs200396959 chr1:207802497    C/T rs971770488 chr1:207802503    T/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DNMT3A	chr2:25496015(-) A-I      intronic chr2:25542814(-) A-I      intronic chr2:25487275(-) A-I      intronic chr2:25494129(-) A-I      intronic chr2:25496016(-) A-I      intronic chr2:25496023(-) A-I      intronic chr2:25496041(-) A-I      intronic chr2:25496046(-) A-I      intronic chr2:25511194(-) A-I      intronic chr2:25516796(-) A-I      intronic chr2:25516798(-) A-I      intronic chr2:25516812(-) A-I      intronic chr2:25516813(-) A-I      intronic chr2:25516828(-) A-I      intronic chr2:25542795(-) A-I      intronic chr2:25542803(-) A-I      intronic chr2:25459059(-) A-I      intronic chr2:25459063(-) A-I      intronic chr2:25459073(-) A-I      intronic chr2:25460432(-) A-I      intronic chr2:25484834(-) A-I      intronic chr2:25486024(-) A-I      intronic chr2:25486077(-) A-I      intronic chr2:25487155(-) A-I      intronic chr2:25488560(-) A-I      intronic chr2:25488572(-) A-I      intronic chr2:25488636(-) A-I      intronic chr2:25490251(-) A-I      intronic chr2:25490289(-) A-I      intronic chr2:25490404(-) A-I      intronic chr2:25490424(-) A-I      intronic chr2:25491934(-) A-I      intronic chr2:25491948(-) A-I      intronic chr2:25492034(-) A-I      intronic chr2:25492042(-) A-I      intronic chr2:25493771(-) A-I      intronic chr2:25493774(-) A-I      intronic chr2:25493784(-) A-I      intronic chr2:25493793(-) A-I      intronic chr2:25493810(-) A-I      intronic chr2:25493811(-) A-I      intronic chr2:25493817(-) A-I      intronic chr2:25494097(-) A-I      intronic chr2:25494891(-) A-I      intronic chr2:25494923(-) A-I      intronic chr2:25494948(-) A-I      intronic chr2:25494988(-) A-I      intronic chr2:25495000(-) A-I      intronic chr2:25495083(-) A-I      intronic chr2:25495088(-) A-I      intronic chr2:25495128(-) A-I      intronic chr2:25495708(-) A-I      intronic chr2:25495709(-) A-I      intronic chr2:25495795(-) A-I      intronic chr2:25495809(-) A-I      intronic chr2:25495831(-) A-I      intronic chr2:25496000(-) A-I      intronic chr2:25496140(-) A-I      intronic chr2:25496223(-) A-I      intronic chr2:25501525(-) A-I      intronic chr2:25502623(-) A-I      intronic chr2:25502658(-) A-I      intronic chr2:25502787(-) A-I      intronic chr2:25502797(-) A-I      intronic chr2:25506192(-) A-I      intronic chr2:25506206(-) A-I      intronic chr2:25506228(-) A-I      intronic chr2:25510852(-) A-I      intronic chr2:25510855(-) A-I      intronic chr2:25510857(-) A-I      intronic chr2:25510863(-) A-I      intronic chr2:25510929(-) A-I      intronic chr2:25511045(-) A-I      intronic chr2:25511060(-) A-I      intronic chr2:25511216(-) A-I      intronic chr2:25512048(-) A-I      intronic chr2:25513252(-) A-I      intronic chr2:25515186(-) A-I      intronic chr2:25515213(-) A-I      intronic chr2:25516387(-) A-I      intronic chr2:25516389(-) A-I      intronic chr2:25516588(-) A-I      intronic chr2:25516598(-) A-I      intronic chr2:25516626(-) A-I      intronic chr2:25540765(-) A-I      intronic chr2:25540792(-) A-I      intronic chr2:25541306(-) A-I      intronic chr2:25542019(-) A-I      intronic chr2:25542058(-) A-I      intronic chr2:25542067(-) A-I      intronic chr2:25542117(-) A-I      intronic chr2:25542256(-) A-I      intronic chr2:25542827(-) A-I      intronic chr2:25543809(-) A-I      intronic chr2:25544748(-) A-I      intronic chr2:25512109(-) A-I      intronic chr2:25501512(-) A-I      intronic chr2:25543902(-) A-I      intronic chr2:25544589(-) A-I      intronic chr2:25544615(-) A-I      intronic chr2:25544620(-) A-I      intronic chr2:25544627(-) A-I      intronic chr2:25544631(-) A-I      intronic chr2:25544655(-) A-I      intronic chr2:25542821(-) A-I      intronic chr2:25502653(-) A-I      intronic chr2:25530473(-) A-I      intronic chr2:25488625(-) A-I      intronic chr2:25515217(-) A-I      intronic chr2:25496024(-) A-I      intronic chr2:25510922(-) A-I      intronic chr2:25492127(-) A-I      intronic chr2:25542022(-) A-I      intronic chr2:25484911(-) A-I      intronic chr2:25541834(-) A-I      intronic chr2:25488666(-) A-I      intronic chr2:25541258(-) A-I      intronic chr2:25488431(-) A-I      intronic chr2:25487604(-) A-I      intronic chr2:25512172(-) A-I      intronic chr2:25511443(-) A-I      intronic chr2:25496117(-) A-I      intronic chr2:25511059(-) A-I      intronic chr2:25487182(-) A-I      intronic chr2:25542218(-) A-I      intronic chr2:25494218(-) A-I      intronic chr2:25471577(-) A-I      intronic chr2:25460512(-) A-I      intronic chr2:25492063(-) A-I      intronic chr2:25485984(-) A-I      intronic chr2:25506155(-) A-I      intronic chr2:25541338(-) A-I      intronic chr2:25542818(-) A-I      intronic chr2:25544606(-) A-I      intronic chr2:25514961(-) A-I      intronic chr2:25541326(-) A-I      intronic chr2:25502759(-) A-I      intronic chr2:25492036(-) A-I      intronic chr2:25487106(-) A-I      intronic chr2:25496118(-) A-I      intronic chr2:25486054(-) A-I      intronic chr2:25543877(-) A-I      intronic chr2:25510978(-) A-I      intronic chr2:25495940(-) A-I      intronic chr2:25464213(-) A-I      intronic chr2:25511224(-) A-I      intronic chr2:25544587(-) A-I      intronic chr2:25541980(-) A-I      intronic chr2:25511337(-) A-I      intronic chr2:25540772(-) A-I      intronic chr2:25542246(-) A-I      intronic chr2:25501529(-) A-I      intronic chr2:25495026(-) A-I      intronic chr2:25542669(-) A-I      intronic chr2:25483763(-) A-I      intronic chr2:25541847(-) A-I      intronic chr2:25487232(-) A-I      intronic chr2:25541348(-) A-I      intronic chr2:25541349(-) A-I      intronic chr2:25502802(-) A-I      intronic chr2:25515135(-) A-I      intronic chr2:25496144(-) A-I      intronic chr2:25507295(-) A-I      intronic chr2:25484812(-) A-I      intronic chr2:25488605(-) A-I      intronic chr2:25501697(-) A-I      intronic chr2:25495982(-) A-I      intronic chr2:25515136(-) A-I      intronic chr2:25540769(-) A-I      intronic chr2:25487512(-) A-I      intronic chr2:25494052(-) A-I      intronic chr2:25515205(-) A-I      intronic chr2:25483780(-) A-I      intronic chr2:25486078(-) A-I      intronic chr2:25495811(-) A-I      intronic chr2:25495120(-) A-I      intronic chr2:25495135(-) A-I      intronic chr2:25487117(-) A-I      intronic chr2:25542776(-) A-I      intronic chr2:25495776(-) A-I      intronic chr2:25502753(-) A-I      intronic chr2:25513265(-) A-I      intronic chr2:25492134(-) A-I      intronic chr2:25492091(-) A-I      intronic chr2:25491973(-) A-I      intronic chr2:25511165(-) A-I      intronic chr2:25511446(-) A-I      intronic chr2:25484811(-) A-I      intronic chr2:25471581(-) A-I      intronic chr2:25506109(-) A-I      intronic chr2:25502694(-) A-I      intronic chr2:25541774(-) A-I      intronic chr2:25491943(-) A-I      intronic chr2:25460506(-) A-I      intronic chr2:25490437(-) A-I      intronic chr2:25544711(-) A-I      intronic chr2:25507407(-) A-I      intronic chr2:25513463(-) A-I      intronic chr2:25523889(-) A-I      intronic chr2:25495782(-) A-I      intronic chr2:25459106(-) A-I      intronic chr2:25542866(-) A-I      intronic chr2:25502810(-) A-I      intronic chr2:25544693(-) A-I      intronic chr2:25541252(-) A-I      intronic chr2:25472078(-) A-I      intronic chr2:25492043(-) A-I      intronic chr2:25543919(-) A-I      intronic chr2:25490278(-) A-I      intronic chr2:25540701(-) A-I      intronic chr2:25494206(-) A-I      intronic chr2:25501638(-) A-I      intronic chr2:25541695(-) A-I      intronic chr2:25540033(-) A-I      intronic chr2:25542728(-) A-I      intronic chr2:25487173(-) A-I      intronic chr2:25494116(-) A-I      intronic chr2:25491947(-) A-I      intronic chr2:25496008(-) A-I      intronic chr2:25510842(-) A-I      intronic chr2:25541434(-) A-I      intronic chr2:25511047(-) A-I      intronic chr2:25541218(-) A-I      intronic chr2:25542724(-) A-I      intronic chr2:25495732(-) A-I      intronic chr2:25544513(-) A-I      intronic chr2:25510887(-) A-I      intronic chr2:25495701(-) A-I      intronic chr2:25542156(-) A-I      intronic chr2:25542291(-) A-I      intronic chr2:25460628(-) A-I      intronic chr2:25494994(-) A-I      intronic chr2:25523905(-) A-I      intronic chr2:25490195(-) A-I      intronic chr2:25459152(-) A-I      intronic chr2:25495968(-) A-I      intronic chr2:25501465(-) A-I      intronic chr2:25492139(-) A-I      intronic chr2:25493957(-) A-I      intronic chr2:25501632(-) A-I      intronic chr2:25542750(-) A-I      intronic chr2:25495027(-) A-I      intronic chr2:25510741(-) A-I      intronic chr2:25542703(-) A-I      intronic chr2:25491928(-) A-I      intronic chr2:25516405(-) A-I      intronic chr2:25472022(-) A-I      intronic chr2:25488674(-) A-I      intronic chr2:25514967(-) A-I      intronic chr2:25513464(-) A-I      intronic chr2:25544643(-) A-I      intronic chr2:25544708(-) A-I      intronic chr2:25493781(-) A-I      intronic chr2:25511136(-) A-I      intronic chr2:25493866(-) A-I      intronic chr2:25543966(-) A-I      intronic chr2:25541705(-) A-I      intronic chr2:25495794(-) A-I      intronic chr2:25541995(-) A-I      intronic chr2:25541320(-) A-I      intronic chr2:25491946(-) A-I      intronic chr2:25540773(-) A-I      intronic chr2:25487496(-) A-I      intronic chr2:25501532(-) A-I      intronic chr2:25543963(-) A-I      intronic chr2:25532803(-) A-I      intronic chr2:25541186(-) A-I      intronic chr2:25544583(-) A-I      intronic chr2:25492079(-) A-I      intronic chr2:25543744(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DNMT3A	chr2:25562084(-) A-G intron -    22484847 chr2:25483780(-) A-G intron -    22484847 chr2:25488625(-) A-G intron -    22484847 chr2:25488686(-) A-T intron -    22484847 chr2:25490407(-) A-G intron -    22484847 chr2:25490437(-) A-G intron -    22484847 chr2:25491946(-) A-G intron -    22484847 chr2:25491973(-) A-G intron -    22484847 chr2:25492002(-) A-G intron -    22484847 chr2:25492029(-) A-G intron -    22484847 chr2:25492036(-) A-G intron -    22484847 chr2:25492043(-) A-G intron -    22484847 chr2:25492063(-) A-G intron -    22484847 chr2:25492069(-) A-G intron -    22484847 chr2:25492127(-) A-G intron -    22484847 chr2:25492134(-) A-G intron -    22484847 chr2:25492139(-) A-G intron -    22484847 chr2:25493781(-) A-G intron -    22484847 chr2:25494049(-) A-G intron -    22484847 chr2:25494116(-) A-G intron -    22484847 chr2:25494206(-) A-G intron -    22484847 chr2:25494994(-) A-G intron -    22484847 chr2:25495026(-) A-G intron -    22484847 chr2:25495027(-) A-G intron -    22484847 chr2:25495129(-) A-G intron -    22484847 chr2:25495135(-) A-G intron -    22484847 chr2:25495940(-) A-G intron -    22484847 chr2:25495968(-) A-G intron -    22484847 chr2:25496263(-) A-G intron -    22484847 chr2:25505997(-) A-G intron -    22484847 chr2:25506155(-) A-G intron -    22484847 chr2:25510922(-) A-G intron -    22484847 chr2:25510932(-) A-G intron -    22484847 chr2:25510977(-) A-G intron -    22484847 chr2:25510978(-) A-G intron -    22484847 chr2:25511047(-) A-G intron -    22484847 chr2:25511059(-) A-G intron -    22484847 chr2:25511136(-) A-G intron -    22484847 chr2:25511165(-) A-G intron -    22484847 chr2:25511168(-) A-G intron -    22484847 chr2:25511224(-) A-G intron -    22484847 chr2:25515097(-) A-G intron -    22484847 chr2:25515107(-) A-G intron -    22484847 chr2:25515135(-) A-G intron -    22484847 chr2:25515136(-) A-G intron -    22484847 chr2:25515205(-) A-G intron -    22484847 chr2:25523901(-) T-A intron -    22484847 chr2:25540769(-) A-G intron -    22484847 chr2:25540772(-) A-G intron -    22484847 chr2:25540773(-) A-G intron -    22484847 chr2:25541218(-) A-G intron -    22484847 chr2:25541258(-) A-G intron -    22484847 chr2:25541434(-) A-G intron -    22484847 chr2:25542821(-) A-G intron -    22484847 chr2:25543784(-) A-G intron -    22484847 chr2:25543835(-) A-G intron -    22484847 chr2:25543877(-) A-G intron -    22484847 chr2:25543919(-) A-G intron -    22484847 chr2:25543963(-) A-G intron -    22484847 chr2:25544703(-) A-G intron -    22484847 chr2:25556291(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DNMT3A	chr2:25450765-25450766(-) m6A 3'UTR       27773535 chr2:25450781-25450782(-) m6A 3'UTR       27773535 chr2:25455857-25455858(-) m6A 3'UTR       27773535 chr2:25455881-25455882(-) m6A 3'UTR       27773535 chr2:25455914-25455915(-) m6A 3'UTR       27773535 chr2:25456042-25456043(-) m6A 3'UTR       24981863 chr2:25456067-25456068(-) m6A 3'UTR       24981863//27773535//27371828 chr2:25456127-25456128(-) m6A 3'UTR       24981863//27773535//27371828 chr2:25456196-25456197(-) m6A 3'UTR       27773535 chr2:25456255-25456256(-) m6A 3'UTR       27773535 chr2:25456273-25456274(-) m6A 3'UTR       27773535 chr2:25456449-25456450(-) m6A 3'UTR       27773535 chr2:25456461-25456462(-) m6A 3'UTR       27773535 chr2:25456487-25456488(-) m6A 3'UTR       27773535 chr2:25456492-25456493(-) m6A 3'UTR       27773535 chr2:25456561-25456562(-) m6A 3'UTR       27773535 chr2:25456861-25456862(-) m6A 3'UTR       27773535 chr2:25456907-25456908(-) m6A 3'UTR       24981863//27773535 chr2:25456912-25456913(-) m6A 3'UTR       24981863//27773535 chr2:25456959-25456960(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr2:25457008-25457009(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr2:25457014-25457015(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085 chr2:25457066-25457067(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457075-25457076(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457085-25457086(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457092-25457093(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457099-25457100(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457107-25457108(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457131-25457132(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457143-25457144(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr2:25457225-25457226(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr2:25458602-25458603(-) m6A 3'UTR//CDS//exon       27773535 chr2:25458638-25458639(-) m6A 3'UTR//CDS//exon       27773535 chr2:25458659-25458660(-) m6A 3'UTR//CDS//exon       27773535 chr2:25458678-25458679(-) m6A 3'UTR//CDS//exon       27773535 chr2:25469131-25469132(-) m6A CDS//exon       27773535 chr2:25469144-25469145(-) m6A CDS//exon       27773535 chr2:25470576-25470577(-) m6A CDS//exon       - chr2:25470948-25470949(-) m6A CDS//exon       24284625//27371828 chr2:25471071-25471072(-) m6A CDS//exon       24284625//25456834//27773535//27371828 chr2:25474814-25474815(-) m6A exon//intron       25456834//24981863//27773535//27371828 chr2:25497867-25497868(-) m6A CDS       27371828//27773536 chr2:25498394-25498395(-) m6A CDS       24209618//27371828//27773536 chr2:25498404-25498405(-) m6A CDS       24209618//27371828//27773536 chr2:25504324-25504325(-) m6A 3'UTR//intron       24209618//27371828//27773536 chr2:25504349-25504350(-) m6A 3'UTR//intron       24209618//27371828//27773536 chr2:25505387-25505388(-) m6A CDS       25456834//24981863//27371828//27773536 chr2:25505482-25505483(-) m6A CDS       24284625//25456834//27371828//27773536 chr2:25505515-25505516(-) m6A CDS       24209618//25456834//27371828//27773536 chr2:25505554-25505555(-) m6A CDS       24209618//25456834//28052920//27371828//27773536 chr2:25536788-25536789(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536 chr2:25536821-25536822(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536 chr2:25536927-25536928(-) m6A 5'UTR       24209618//24981863//27773535//27371828//27773536 chr2:25565320-25565321(-) m6A 5'UTR       27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-2-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	DNMT3A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-2-5p
Interactor2: DNMT3A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRecords
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Additional file 6. List of validated miRNA targets from miRecords and miRTarBase databases.