Detail Information

Basic Information:


  VIRBase ID:  

HHID00009753

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-2-5p:           CDK6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-2-5p CDK6
miRBase
Accession/Entrez ID		 MIMAT0004515 1021
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MCPH12//PLSTIRE

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-2-5p
rs1389711693 chr1:207802500    C/A
rs200396959 chr1:207802497    C/T
rs971770488 chr1:207802503    T/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CDK6
chr7:92441963(-) A-I      intronic
chr7:92441245(-) A-I      intronic
chr7:92292893(-) A-I      intronic
chr7:92441384(-) A-I      intronic
chr7:92409909(-) A-I      intronic
chr7:92409885(-) A-I      intronic
chr7:92409567(-) A-I      intronic
chr7:92409513(-) A-I      intronic
chr7:92409490(-) A-I      intronic
chr7:92292929(-) A-I      intronic
chr7:92409489(-) A-I      intronic
chr7:92367853(-) A-I      intronic
chr7:92304318(-) A-I      intronic
chr7:92292932(-) A-I      intronic
chr7:92292933(-) A-I      intronic
chr7:92361674(-) A-I      intronic
chr7:92363285(-) A-I      intronic
chr7:92361587(-) A-I      intronic
chr7:92292952(-) A-I      intronic
chr7:92361529(-) A-I      intronic
chr7:92361515(-) A-I      intronic
chr7:92292958(-) A-I      intronic
chr7:92292968(-) A-I      intronic
chr7:92293288(-) A-I      intronic
chr7:92293291(-) A-I      intronic
chr7:92293333(-) A-I      intronic
chr7:92361514(-) A-I      intronic
chr7:92356004(-) A-I      intronic
chr7:92355997(-) A-I      intronic
chr7:92341470(-) A-I      intronic
chr7:92377379(-) A-I      intronic
chr7:92397419(-) A-I      intronic
chr7:92341390(-) A-I      intronic
chr7:92340958(-) A-I      intronic
chr7:92322004(-) A-I      intronic
chr7:92309567(-) A-I      intronic
chr7:92309536(-) A-I      intronic
chr7:92309132(-) A-I      intronic
chr7:92306881(-) A-I      intronic
chr7:92306850(-) A-I      intronic
chr7:92306847(-) A-I      intronic
chr7:92306784(-) A-I      intronic
chr7:92306775(-) A-I      intronic
chr7:92306749(-) A-I      intronic
chr7:92306714(-) A-I      intronic
chr7:92306697(-) A-I      intronic
chr7:92341338(-) A-I      intronic
chr7:92293433(-) A-I      intronic
chr7:92294294(-) A-I      intronic
chr7:92296590(-) A-I      intronic
chr7:92296736(-) A-I      intronic
chr7:92296737(-) A-I      intronic
chr7:92304317(-) A-I      intronic
chr7:92304352(-) A-I      intronic
chr7:92292857(-) A-I      intronic
chr7:92292797(-) A-I      intronic
chr7:92292767(-) A-I      intronic
chr7:92363291(-) A-I      intronic
chr7:92341058(-) A-I      intronic
chr7:92341059(-) A-I      intronic
chr7:92341061(-) A-I      intronic
chr7:92341309(-) A-I      intronic
chr7:92341321(-) A-I      intronic
chr7:92367757(-) A-I      intronic
chr7:92367774(-) A-I      intronic
chr7:92441390(-) A-I      intronic
chr7:92367829(-) A-I      intronic
chr7:92442013(-) A-I      intronic
chr7:92342270(-) A-I      intronic
chr7:92280373(-) A-I      intronic
chr7:92309097(-) A-I      intronic
chr7:92341313(-) A-I      intronic
chr7:92309163(-) A-I      intronic
chr7:92309292(-) A-I      intronic
chr7:92306811(-) A-I      intronic
chr7:92341387(-) A-I      intronic
chr7:92342422(-) A-I      intronic
chr7:92341050(-) A-I      intronic
chr7:92341328(-) A-I      intronic
chr7:92341353(-) A-I      intronic
chr7:92409824(-) A-I      intronic
chr7:92341411(-) A-I      intronic
chr7:92309205(-) A-I      intronic
chr7:92441376(-) A-I      intronic
chr7:92391993(-) A-I      intronic
chr7:92341443(-) A-I      intronic
chr7:92297084(-) A-I      intronic
chr7:92304214(-) A-I      intronic
chr7:92303256(-) A-I      intronic
chr7:92292768(-) A-I      intronic
chr7:92382899(-) A-I      intronic
chr7:92361481(-) A-I      intronic
chr7:92306884(-) A-I      intronic
chr7:92431152(-) A-I      intronic
chr7:92294378(-) A-I      intronic
chr7:92367697(-) A-I      intronic
chr7:92294274(-) A-I      intronic
chr7:92341051(-) A-I      intronic
chr7:92294238(-) A-I      intronic
chr7:92441293(-) A-I      intronic
chr7:92369367(-) A-I      intronic
chr7:92441302(-) A-I      intronic
chr7:92341344(-) A-I      intronic
chr7:92431064(-) A-I      intronic
chr7:92306739(-) A-I      intronic
chr7:92294264(-) A-I      intronic
chr7:92293331(-) A-I      intronic
chr7:92280372(-) A-I      intronic
chr7:92392020(-) A-I      intronic
chr7:92284363(-) A-I      intronic
chr7:92441210(-) A-I      intronic
chr7:92296739(-) A-I      intronic
chr7:92361669(-) A-I      intronic
chr7:92306760(-) A-I      intronic
chr7:92309646(-) A-I      intronic
chr7:92359205(-) A-I      intronic
chr7:92309699(-) A-I      intronic
chr7:92341046(-) A-I      intronic
chr7:92294372(-) A-I      intronic
chr7:92391971(-) A-I      intronic
chr7:92409462(-) A-I      intronic
chr7:92442012(-) A-I      intronic
chr7:92355951(-) A-I      intronic
chr7:92369323(-) A-I      intronic
chr7:92306892(-) A-I      intronic
chr7:92409575(-) A-I      intronic
chr7:92341308(-) A-I      intronic
chr7:92340974(-) A-I      intronic
chr7:92292762(-) A-I      intronic
chr7:92410031(-) A-I      intronic
chr7:92292852(-) A-I      intronic
chr7:92309111(-) A-I      intronic
chr7:92283201(-) A-I      intronic
chr7:92361586(-) A-I      intronic
chr7:92409464(-) A-I      intronic
chr7:92306857(-) A-I      intronic
chr7:92341354(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CDK6
chr7:92318639(-) G-A intron -    22484847
chr7:92280321(-) T-C intron -    22484847
chr7:92280328(-) G-A intron -    22484847
chr7:92287266(-) C-G intron -    22484847
chr7:92292756(-) A-G intron -    22484847
chr7:92292762(-) A-G intron -    22484847
chr7:92292768(-) A-G intron -    22484847
chr7:92292771(-) A-G intron -    22484847
chr7:92292852(-) A-G intron -    22484847
chr7:92293306(-) A-G intron -    22484847
chr7:92293331(-) A-G intron -    22484847
chr7:92294238(-) A-G intron -    22484847
chr7:92294264(-) A-G intron -    22484847
chr7:92294268(-) A-G intron -    22484847
chr7:92294269(-) A-G intron -    22484847
chr7:92294274(-) A-G intron -    22484847
chr7:92294282(-) T-C intron -    22484847
chr7:92294372(-) A-G intron -    22484847
chr7:92294378(-) A-G intron -    22484847
chr7:92296739(-) A-G intron -    22484847
chr7:92306739(-) A-G intron -    22484847
chr7:92306760(-) A-G intron -    22484847
chr7:92306857(-) A-G intron -    22484847
chr7:92309097(-) A-G intron -    22484847
chr7:92309111(-) A-G intron -    22484847
chr7:92309131(-) A-G intron -    22484847
chr7:92309292(-) A-G intron -    22484847
chr7:92309618(-) A-G intron -    22484847
chr7:92309624(-) A-G intron -    22484847
chr7:92309634(-) A-G intron -    22484847
chr7:92309646(-) A-G intron -    22484847
chr7:92309669(-) A-G intron -    22484847
chr7:92309699(-) A-G intron -    22484847
chr7:92309707(-) A-G intron -    22484847
chr7:92321576(-) A-C intron -    22484847
chr7:92321577(-) G-T intron -    22484847
chr7:92321580(-) T-C intron -    22484847
chr7:92331565(-) C-A intron -    22484847
chr7:92340974(-) A-G intron -    22484847
chr7:92340989(-) A-G intron -    22484847
chr7:92341046(-) A-G intron -    22484847
chr7:92341049(-) A-G intron -    22484847
chr7:92341050(-) A-G intron -    22484847
chr7:92341075(-) A-G intron -    22484847
chr7:92341078(-) A-G intron -    22484847
chr7:92341085(-) A-G intron -    22484847
chr7:92341308(-) A-G intron -    22484847
chr7:92341313(-) A-G intron -    22484847
chr7:92341335(-) A-G intron -    22484847
chr7:92341344(-) A-G intron -    22484847
chr7:92341353(-) A-G intron -    22484847
chr7:92341387(-) A-G intron -    22484847
chr7:92341443(-) A-G intron -    22484847
chr7:92342377(-) T-G intron -    22484847
chr7:92342422(-) A-G intron -    22484847
chr7:92355951(-) A-G intron -    22484847
chr7:92359192(-) A-G intron -    22484847
chr7:92359205(-) A-G intron -    22484847
chr7:92361481(-) A-G intron -    22484847
chr7:92361586(-) A-G intron -    22484847
chr7:92361669(-) A-G intron -    22484847
chr7:92378531(-) C-T intron -    22484847
chr7:92382899(-) A-G intron -    22484847
chr7:92409462(-) A-G intron -    22484847
chr7:92409463(-) A-G intron -    22484847
chr7:92409464(-) A-G intron -    22484847
chr7:92409466(-) A-G intron -    22484847
chr7:92409575(-) A-G intron -    22484847
chr7:92409824(-) A-G intron -    22484847
chr7:92409907(-) A-G intron -    22484847
chr7:92410031(-) A-G intron -    22484847
chr7:92416499(-) G-T intron -    22484847
chr7:92431064(-) A-G intron -    22484847
chr7:92431152(-) A-G intron -    22484847
chr7:92440305(-) T-C intron -    22484847
chr7:92441210(-) A-G intron -    22484847
chr7:92441293(-) A-G intron -    22484847
chr7:92441302(-) A-G intron -    22484847
chr7:92441376(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CDK6
chr7:92238336-92238337(-) m6A 3'UTR       27773535
chr7:92238382-92238383(-) m6A 3'UTR       27773535
chr7:92238416-92238417(-) m6A 3'UTR       27773535
chr7:92238996-92238997(-) m6A 3'UTR       27773535
chr7:92239020-92239021(-) m6A 3'UTR       27773535
chr7:92239047-92239048(-) m6A 3'UTR       27773535
chr7:92239085-92239086(-) m6A 3'UTR       27773535
chr7:92244214-92244215(-) m6A 3'UTR//exon       -
chr7:92244302-92244303(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr7:92244325-92244326(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr7:92244416-92244417(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr7:92244478-92244479(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr7:92244508-92244509(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr7:92244529-92244530(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr7:92247395-92247396(-) m6A CDS//exon       24284625//24981863//27773535
chr7:92247406-92247407(-) m6A CDS//exon       24284625//24981863//27773535
chr7:92247494-92247495(-) m6A CDS//exon       24284625//27773535
chr7:92331058-92331059(-) Am intron       16381836
chr7:92331065-92331066(-) Cm intron       16381836
chr7:92331066-92331067(-) Cm intron       16381836
chr7:92331068-92331069(-) Cm intron       16381836
chr7:92331074-92331075(-) Gm intron       16381836
chr7:92331075-92331076(-) Am intron       16381836
chr7:92331081-92331082(-) Am intron       16381836
chr7:92462429-92462430(-) m6A CDS       -
chr7:92462492-92462493(-) m6A CDS       24284625//27371828//27773536//22575960
chr7:92462741-92462742(-) m6A 5'UTR//exon       24209618//27371828//27773536//22575960
chr7:92462940-92462941(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//27773536//22575960
chr7:92462988-92462989(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr7:92464512-92464513(-) m6A exon//intron       25456834
chr7:92464576-92464577(-) m6A exon//intron       24981863
chr7:92464608-92464609(-) m6A exon//intron       24981863
chr7:92465857-92465858(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-2-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
CDK6
Chromatin HCC cell line (HepG2)|K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-2-5p
Interactor2: CDK6

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRecords
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Additional file 6. List of validated miRNA targets from miRecords and miRTarBase databases.

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