Basic Information:

  VIRBase ID:  

HHID00009747

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-1-5p:  MIMAT0004514          PIK3R1:  NM_001242466     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-29b-1-5p	PIK3R1
miRBase Accession/Entrez ID	MIMAT0004514	5295
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AGM7//GRB1//IMD36//p85//p85-ALPHA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-29b-1-5p	rs1189550020 chr7:130877522    G/GA rs1554489373 chr7:130877519    T/C rs1554489375 chr7:130877520    A/C rs782109811 chr7:130877509    TA/T rs778204762 chr7:130877526    C/A rs778204762 chr7:130877526    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3R1	chr5:67531060(+) A-I      intronic chr5:67531069(+) A-I      intronic chr5:67532338(+) A-I      intronic chr5:67532276(+) A-I      intronic chr5:67532214(+) A-I      intronic chr5:67532207(+) A-I      intronic chr5:67532339(+) A-I      intronic chr5:67596823(+) A-I      3'UTR chr5:67568022(+) A-I      intronic chr5:67530969(+) A-I      intronic chr5:67531066(+) A-I      intronic chr5:67568010(+) A-I      intronic chr5:67568001(+) A-I      intronic chr5:67530992(+) A-I      intronic chr5:67542306(+) A-I      intronic chr5:67552114(+) A-I      intronic chr5:67530981(+) A-I      intronic chr5:67532284(+) A-I      intronic chr5:67574701(+) A-I      intronic chr5:67567942(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3R1	chr5:67594134(+) A-C intron -    21725310 chr5:67530969(+) A-G intron -    22484847 chr5:67530981(+) A-G intron -    22484847 chr5:67531029(+) A-G intron -    22484847 chr5:67531044(+) A-G intron -    22484847 chr5:67531066(+) A-G intron -    22484847 chr5:67532262(+) A-G intron -    22484847 chr5:67532284(+) A-G intron -    22484847 chr5:67552114(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3R1	chr5:67511712-67511713(+) m6A 5'UTR       24209618//24981863//27371828 chr5:67513348-67513349(+) m6A exon//intron       24981863 chr5:67513580-67513581(+) m6A exon//intron       24209618 chr5:67522164-67522165(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522263-67522264(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522318-67522319(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522326-67522327(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522358-67522359(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522391-67522392(+) m6A 5'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67522452-67522453(+) m6A 5'UTR//exon       24209618//24981863//26404942//22575960//22608085 chr5:67522501-67522502(+) m6A 5'UTR//exon       24209618//24981863//26404942//22575960//22608085 chr5:67522637-67522638(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:67522686-67522687(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:67522705-67522706(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:67522716-67522717(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:67522812-67522813(+) m6A CDS//exon       24981863//26404942//22608085 chr5:67522829-67522830(+) m6A CDS//exon       24981863//26404942//22608085 chr5:67535736-67535737(+) m6A CDS//intron       24981863//22608085 chr5:67535747-67535748(+) m6A CDS//intron       24981863//22608085 chr5:67590381-67590382(+) m6A 3'UTR//CDS//exon       24981863 chr5:67590405-67590406(+) m6A 3'UTR//CDS//exon       24981863 chr5:67590425-67590426(+) m6A 3'UTR//CDS//exon       24981863 chr5:67590435-67590436(+) m6A 3'UTR//CDS//exon       24981863 chr5:67591049-67591050(+) m6A 3'UTR//CDS//exon       24981863 chr5:67591097-67591098(+) m6A 3'UTR//CDS//exon       24981863 chr5:67591107-67591108(+) m6A 3'UTR//CDS//exon       24981863 chr5:67591112-67591113(+) m6A 3'UTR//CDS//exon       24981863 chr5:67591139-67591140(+) m6A 3'UTR//CDS//exon       24981863 chr5:67592142-67592143(+) m6A CDS//exon       24981863 chr5:67593271-67593272(+) m6A CDS//exon       24981863//26404942//22575960//22608085 chr5:67593276-67593277(+) m6A CDS//exon       24284625//24981863//26404942//22575960//22608085 chr5:67593332-67593333(+) m6A CDS//exon       24284625//24981863//26404942//22575960//22608085 chr5:67593555-67593556(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67593592-67593593(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67593740-67593741(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67593805-67593806(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67593838-67593839(+) m6A 3'UTR//exon       24209618//25456834//24981863//26404942//22608085 chr5:67593899-67593900(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr5:67593905-67593906(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085 chr5:67594066-67594067(+) m6A 3'UTR//exon       24981863//26404942//22575960//22608085 chr5:67594072-67594073(+) m6A 3'UTR//exon       24981863//26404942//22575960//22608085 chr5:67594102-67594103(+) m6A 3'UTR//exon       24981863//26404942//22575960//22608085 chr5:67594107-67594108(+) m6A 3'UTR//exon       24981863//26404942//22575960//22608085 chr5:67594631-67594632(+) m6A 3'UTR       26404942 chr5:67594680-67594681(+) m6A 3'UTR       26404942 chr5:67596181-67596182(+) m6A 3'UTR       - chr5:67596473-67596474(+) m6A 3'UTR       26404942 chr5:67596503-67596504(+) m6A 3'UTR       26404942 chr5:67597109-67597110(+) m6A 3'UTR       26404942 chr5:67597129-67597130(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-29b-1-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	PIK3R1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-29b-1-5p
Interactor2: PIK3R1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRecords
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Additional file 6. List of validated miRNA targets from miRecords and miRTarBase databases.