Detail Information

Basic Information:


  VIRBase ID:  

HHID00009746

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-29b-1-5p:           MMP2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-29b-1-5p MMP2
miRBase
Accession/Entrez ID		 MIMAT0004514 4313
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CLG4//CLG4A//MMP-2//MMP-II//MONA//TBE-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-29b-1-5p
rs1189550020 chr7:130877522    G/GA
rs1554489373 chr7:130877519    T/C
rs1554489375 chr7:130877520    A/C
rs782109811 chr7:130877509    TA/T
rs778204762 chr7:130877526    C/A
rs778204762 chr7:130877526    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MMP2
chr16:55539009(+) A-I      intronic
chr16:55537995(+) A-I      intronic
chr16:55538025(+) A-I      intronic
chr16:55533094(+) A-I      intronic
chr16:55537949(+) A-I      intronic
chr16:55537883(+) A-I      intronic
chr16:55539077(+) A-I      intronic
chr16:55538004(+) A-I      intronic
chr16:55537832(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MMP2
chr16:55513120-55513121(+) m6A 5'UTR//intron       24209618//24981863
chr16:55513164-55513165(+) m6A 5'UTR//intron       24209618//24981863
chr16:55513185-55513186(+) m6A 5'UTR//intron       24209618//24981863
chr16:55513232-55513233(+) m6A 5'UTR//intron       24209618//24981863//27773536
chr16:55513256-55513257(+) m6A 5'UTR//intron       24209618//24981863//27773536
chr16:55513279-55513280(+) m6A 5'UTR//intron       24209618//27773536
chr16:55513527-55513528(+) m6A CDS//intron       24981863
chr16:55513914-55513915(+) m6A 5'UTR//intron       24981863
chr16:55513925-55513926(+) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-29b-1-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
MMP2
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-29b-1-5p
Interactor2: MMP2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRecords
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Additional file 6. List of validated miRNA targets from miRecords and miRTarBase databases.

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