Basic Information:

  VIRBase ID:  

HHID00009666

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:  MIMAT0004513          ACER2:  NM_001010887     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-5p	ACER2
miRBase Accession/Entrez ID	MIMAT0004513	340485
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALKCDase2//ASAH3L

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-5p	rs1200170859 chr1:65058478    G/C rs548109012 chr1:65058477    A/G rs548109012 chr1:65058477    A/T rs1235943983 chr1:65058493    T/C rs746487797 chr1:65058492    A/G rs777575128 chr1:65058491    G/C rs777575128 chr1:65058491    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ACER2	chr9:19434612(+) A-I      intronic chr9:19434620(+) A-I      intronic chr9:19428977(+) A-I      intronic chr9:19443890(+) A-I      intronic chr9:19434621(+) A-I      intronic chr9:19439711(+) A-I      intronic chr9:19434651(+) A-I      intronic chr9:19443902(+) A-I      intronic chr9:19430687(+) A-I      intronic chr9:19416588(+) A-I      intronic chr9:19415443(+) A-I      intronic chr9:19439845(+) A-I      intronic chr9:19439890(+) A-I      intronic chr9:19416714(+) A-I      intronic chr9:19439710(+) A-I      intronic chr9:19439400(+) A-I      intronic chr9:19411508(+) A-I      intronic chr9:19430806(+) A-I      intronic chr9:19430805(+) A-I      intronic chr9:19430791(+) A-I      intronic chr9:19430825(+) A-I      intronic chr9:19430836(+) A-I      intronic chr9:19430780(+) A-I      intronic chr9:19430778(+) A-I      intronic chr9:19435629(+) A-I      intronic chr9:19435685(+) A-I      intronic chr9:19435732(+) A-I      intronic chr9:19438845(+) A-I      intronic chr9:19439378(+) A-I      intronic chr9:19439389(+) A-I      intronic chr9:19416783(+) A-I      intronic chr9:19412597(+) A-I      intronic chr9:19439425(+) A-I      intronic chr9:19439441(+) A-I      intronic chr9:19439495(+) A-I      intronic chr9:19439811(+) A-I      intronic chr9:19439850(+) A-I      intronic chr9:19439941(+) A-I      intronic chr9:19444274(+) A-I      intronic chr9:19416663(+) A-I      intronic chr9:19443820(+) A-I      intronic chr9:19444290(+) A-I      intronic chr9:19443855(+) A-I      intronic chr9:19439952(+) A-I      intronic chr9:19448079(+) A-I      intronic chr9:19439961(+) A-I      intronic chr9:19441173(+) A-I      intronic chr9:19448123(+) A-I      intronic chr9:19448132(+) A-I      intronic chr9:19449073(+) A-I      intronic chr9:19448288(+) A-I      intronic chr9:19441174(+) A-I      intronic chr9:19439844(+) A-I      intronic chr9:19441278(+) A-I      intronic chr9:19441283(+) A-I      intronic chr9:19442935(+) A-I      intronic chr9:19443710(+) A-I      intronic chr9:19448892(+) A-I      intronic chr9:19443741(+) A-I      intronic chr9:19443755(+) A-I      intronic chr9:19443857(+) A-I      intronic chr9:19439814(+) A-I      intronic chr9:19443794(+) A-I      intronic chr9:19439810(+) A-I      intronic chr9:19439808(+) A-I      intronic chr9:19439762(+) A-I      intronic chr9:19416740(+) A-I      intronic chr9:19416793(+) A-I      intronic chr9:19434607(+) A-I      intronic chr9:19419068(+) A-I      intronic chr9:19419085(+) A-I      intronic chr9:19416603(+) A-I      intronic chr9:19419109(+) A-I      intronic chr9:19426864(+) A-I      intronic chr9:19443800(+) A-I      intronic chr9:19449908(+) A-I      intronic chr9:19428224(+) A-I      intronic chr9:19428230(+) A-I      intronic chr9:19428259(+) A-I      intronic chr9:19439727(+) A-I      intronic chr9:19436042(+) A-I      intronic chr9:19448172(+) A-I      intronic chr9:19439431(+) A-I      intronic chr9:19439818(+) A-I      intronic chr9:19419700(+) A-I      intronic chr9:19410444(+) A-I      intronic chr9:19430841(+) A-I      intronic chr9:19416624(+) A-I      intronic chr9:19449007(+) A-I      intronic chr9:19415343(+) A-I      intronic chr9:19449907(+) A-I      intronic chr9:19448211(+) A-I      intronic chr9:19419114(+) A-I      intronic chr9:19439871(+) A-I      intronic chr9:19448910(+) A-I      intronic chr9:19449034(+) A-I      intronic chr9:19448884(+) A-I      intronic chr9:19410650(+) A-I      intronic chr9:19443724(+) A-I      intronic chr9:19430845(+) A-I      intronic chr9:19430785(+) A-I      intronic chr9:19435705(+) A-I      intronic chr9:19449080(+) A-I      intronic chr9:19423549(+) A-I      intronic chr9:19449078(+) A-I      intronic chr9:19418970(+) A-I      intronic chr9:19448292(+) A-I      intronic chr9:19439886(+) A-I      intronic chr9:19443784(+) A-I      intronic chr9:19439438(+) A-I      intronic chr9:19443349(+) A-I      intronic chr9:19439823(+) A-I      intronic chr9:19441085(+) A-I      intronic chr9:19439526(+) A-I      intronic chr9:19435630(+) A-I      intronic chr9:19439437(+) A-I      intronic chr9:19411457(+) A-I      intronic chr9:19430809(+) A-I      intronic chr9:19428836(+) A-I      intronic chr9:19442943(+) A-I      intronic chr9:19419650(+) A-I      intronic chr9:19416604(+) A-I      intronic chr9:19435831(+) A-I      intronic chr9:19428865(+) A-I      intronic chr9:19439953(+) A-I      intronic chr9:19429591(+) A-I      intronic chr9:19414539(+) A-I      intronic chr9:19411463(+) A-I      intronic chr9:19448194(+) A-I      intronic chr9:19438888(+) A-I      intronic chr9:19448225(+) A-I      intronic chr9:19438887(+) A-I      intronic chr9:19427726(+) A-I      intronic chr9:19430901(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ACER2	chr9:19451067-19451068(+) m6A 3'UTR       24981863//22608085 chr9:19451210-19451211(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451241-19451242(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451257-19451258(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451273-19451274(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451278-19451279(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451337-19451338(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451342-19451343(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451347-19451348(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451356-19451357(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451367-19451368(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:19451473-19451474(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451504-19451505(+) m6A 3'UTR       24284625//24981863//22608085 chr9:19451519-19451520(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451667-19451668(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451679-19451680(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:19451695-19451696(+) m6A 3'UTR       24209618//24981863//22608085 chr9:19451768-19451769(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-101-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ACER2	Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-101-5p	Benzothiazole 7222 Drug interaction    RC00006831

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-101-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-5p
Interactor2: ACER2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).