Detail Information

Basic Information:


  VIRBase ID:  

HHID00009647

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           BLOC1S2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p BLOC1S2
miRBase
Accession/Entrez ID		 MIMAT0004513 282991
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BLOS2//BORCS2//CEAP//CEAP11

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BLOC1S2
chr10:102045111(-) A-I      intronic
chr10:102044706(-) A-I      intronic
chr10:102045222(-) A-I      intronic
chr10:102043585(-) A-I      intronic
chr10:102044173(-) A-I      intronic
chr10:102045157(-) A-I      intronic
chr10:102045127(-) A-I      intronic
chr10:102045072(-) A-I      intronic
chr10:102043532(-) A-I      intronic
chr10:102045306(-) A-I      intronic
chr10:102045116(-) A-I      intronic
chr10:102044187(-) A-I      intronic
chr10:102045192(-) A-I      intronic
chr10:102041228(-) A-I      intronic
chr10:102041277(-) A-I      intronic
chr10:102043556(-) A-I      intronic
chr10:102041324(-) A-I      intronic
chr10:102043507(-) A-I      intronic
chr10:102041354(-) A-I      intronic
chr10:102043632(-) A-I      intronic
chr10:102038590(-) A-I      intronic
chr10:102038608(-) A-I      intronic
chr10:102045220(-) A-I      intronic
chr10:102044417(-) A-I      intronic
chr10:102033959(-) A-I      3'UTR
chr10:102043550(-) A-I      intronic
chr10:102043510(-) A-I      intronic
chr10:102043546(-) A-I      intronic
chr10:102038805(-) A-I      intronic
chr10:102045246(-) A-I      intronic
chr10:102043598(-) A-I      intronic
chr10:102038813(-) A-I      intronic
chr10:102043440(-) A-I      intronic
chr10:102045198(-) A-I      intronic
chr10:102039324(-) A-I      intronic
chr10:102043508(-) A-I      intronic
chr10:102038732(-) A-I      intronic
chr10:102045115(-) A-I      intronic
chr10:102045044(-) A-I      intronic
chr10:102044214(-) A-I      intronic
chr10:102044810(-) A-I      intronic
chr10:102044225(-) A-I      intronic
chr10:102043465(-) A-I      intronic
chr10:102043205(-) A-I      intronic
chr10:102045183(-) A-I      intronic
chr10:102044175(-) A-I      intronic
chr10:102041260(-) A-I      intronic
chr10:102039510(-) A-I      intronic
chr10:102041353(-) A-I      intronic
chr10:102043142(-) A-I      intronic
chr10:102041329(-) A-I      intronic
chr10:102044189(-) A-I      intronic
chr10:102043206(-) A-I      intronic
chr10:102045212(-) A-I      intronic
chr10:102043200(-) A-I      intronic
chr10:102044327(-) A-I      intronic
chr10:102045256(-) A-I      intronic
chr10:102045221(-) A-I      intronic
chr10:102043462(-) A-I      intronic
chr10:102038722(-) A-I      intronic
chr10:102041235(-) A-I      intronic
chr10:102043214(-) A-I      intronic
chr10:102044388(-) A-I      intronic
chr10:102039520(-) A-I      intronic
chr10:102038792(-) A-I      intronic
chr10:102045213(-) A-I      intronic
chr10:102045124(-) A-I      intronic
chr10:102043410(-) A-I      intronic
chr10:102043569(-) A-I      intronic
chr10:102044475(-) A-I      intronic
chr10:102041274(-) A-I      intronic
chr10:102038651(-) A-I      intronic
chr10:102042921(-) A-I      intronic
chr10:102042116(-) A-I      intronic
chr10:102042107(-) A-I      intronic
chr10:102033787(-) A-I      3'UTR
chr10:102044649(-) A-I      intronic
chr10:102035818(-) A-I      intronic
chr10:102042947(-) A-I      intronic
chr10:102043049(-) A-I      intronic
chr10:102042979(-) A-I      intronic
chr10:102042962(-) A-I      intronic
chr10:102044648(-) A-I      intronic
chr10:102043014(-) A-I      intronic
chr10:102045156(-) A-I      intronic
chr10:102043043(-) A-I      intronic
chr10:102043004(-) A-I      intronic
chr10:102033792(-) A-I      3'UTR
chr10:102041846(-) A-I      intronic
chr10:102044672(-) A-I      intronic
chr10:102043549(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BLOC1S2
chr10:102042921(-) A-I intron -    22327324
chr10:102043507(-) A-I intron -    22327324
chr10:102042921(-) A-G intron -    22484847
chr10:102043043(-) A-G intron -    22484847
chr10:102043507(-) A-G intron -    22484847
chr10:102043510(-) A-G intron -    22484847
chr10:102044648(-) A-G intron -    22484847
chr10:102044649(-) A-G intron -    22484847
chr10:102044672(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BLOC1S2
chr10:102034196-102034197(-) m6A 3'UTR       27773535
chr10:102034227-102034228(-) m6A 3'UTR       27773535
chr10:102034534-102034535(-) m6A 3'UTR       27773535
chr10:102034540-102034541(-) m6A 3'UTR       27773535
chr10:102034765-102034766(-) m6A 3'UTR       27773535
chr10:102034770-102034771(-) m6A 3'UTR       27773535
chr10:102034796-102034797(-) m6A 3'UTR       27773535
chr10:102034906-102034907(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034932-102034933(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034940-102034941(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr10:102034960-102034961(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102034966-102034967(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035034-102035035(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035046-102035047(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035063-102035064(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035071-102035072(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:102035091-102035092(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:102035158-102035159(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:102035199-102035200(-) m6A 3'UTR       24209618//24981863//27773535//27371828//27773536//22608085
chr10:102035214-102035215(-) m6A 3'UTR       24209618//24981863//27773535//27371828//27773536//22608085
chr10:102039815-102039816(-) m6A CDS//intron       24981863//27773535//27371828//27773536//22608085
chr10:102039844-102039845(-) m6A CDS//intron       24981863//27773535//27371828//27773536//22608085
chr10:102039884-102039885(-) m6A CDS       27773535//27773536
chr10:102039977-102039978(-) m6A CDS       26404942
chr10:102040698-102040699(-) m6A CDS//exon       26404942
chr10:102040704-102040705(-) m6A CDS//exon       24981863//26404942
chr10:102040713-102040714(-) m6A CDS//exon       24981863//26404942
chr10:102040725-102040726(-) m6A CDS//exon       24981863//26404942
chr10:102040769-102040770(-) m6A CDS//exon       24981863//26404942
chr10:102040797-102040798(-) m6A CDS//exon       24981863//26404942//27371828
chr10:102045860-102045861(-) m6A CDS//exon       24981863//26404942//27371828
chr10:102045897-102045898(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828
chr10:102045952-102045953(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535//27371828
chr10:102045996-102045997(-) m6A 5'UTR//exon//intron       24209618//24981863//27773535//27371828//22608085
chr10:102046036-102046037(-) m6A 5'UTR//exon//intron       24209618//25456834//24981863//27773535//27371828//22608085
chr10:102046105-102046106(-) m6A 5'UTR//intron       24209618//25456834//24981863//27773535//27371828
chr10:102046432-102046433(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BLOC1S2
Chromatin K562 cells     -
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: BLOC1S2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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