Basic Information:

  VIRBase ID:  

HHID00009634

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:  MIMAT0004513          HNRNPA3:  NM_001330250     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-5p	HNRNPA3
miRBase Accession/Entrez ID	MIMAT0004513	220988
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	2610510D13Rik//D10S102//FBRNP//HNRPA3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-5p	rs1200170859 chr1:65058478    G/C rs548109012 chr1:65058477    A/G rs548109012 chr1:65058477    A/T rs1235943983 chr1:65058493    T/C rs746487797 chr1:65058492    A/G rs777575128 chr1:65058491    G/C rs777575128 chr1:65058491    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HNRNPA3	chr2:178082325(+) A-I      intronic chr2:178082291(+) A-I      intronic chr2:178082277(+) A-I      intronic chr2:178087695(+) A-I      3'UTR chr2:178087696(+) A-I      3'UTR chr2:178087699(+) A-I      3'UTR chr2:178082269(+) A-I      intronic chr2:178087935(+) A-I      3'UTR chr2:178087924(+) A-I      3'UTR chr2:178087917(+) A-I      3'UTR chr2:178087916(+) A-I      3'UTR chr2:178087912(+) A-I      3'UTR chr2:178087682(+) A-I      3'UTR chr2:178087894(+) A-I      3'UTR chr2:178087878(+) A-I      3'UTR chr2:178087739(+) A-I      3'UTR chr2:178087738(+) A-I      3'UTR chr2:178087718(+) A-I      3'UTR chr2:178087679(+) A-I      3'UTR chr2:178079978(+) A-I      intronic chr2:178087717(+) A-I      3'UTR chr2:178087709(+) A-I      3'UTR chr2:178087701(+) A-I      3'UTR chr2:178082282(+) A-I      intronic chr2:178079475(+) A-I      intronic chr2:178079338(+) A-I      intronic chr2:178079892(+) A-I      intronic chr2:178079962(+) A-I      intronic chr2:178079910(+) A-I      intronic chr2:178079468(+) A-I      intronic chr2:178082259(+) A-I      intronic chr2:178079269(+) A-I      intronic chr2:178079376(+) A-I      intronic chr2:178087379(+) A-I      3'UTR chr2:178087411(+) A-I      3'UTR chr2:178087352(+) A-I      3'UTR chr2:178079346(+) A-I      intronic chr2:178080099(+) A-I      intronic chr2:178079895(+) A-I      intronic chr2:178079911(+) A-I      intronic chr2:178082250(+) A-I      intronic chr2:178079964(+) A-I      intronic chr2:178079402(+) A-I      intronic chr2:178080032(+) A-I      intronic chr2:178079867(+) A-I      intronic chr2:178080006(+) A-I      intronic chr2:178079952(+) A-I      intronic chr2:178079905(+) A-I      intronic chr2:178079887(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HNRNPA3	chr2:178079268(+) A-G intron -    22484847 chr2:178079269(+) A-G intron -    22484847 chr2:178079289(+) C-T intron -    22484847 chr2:178079376(+) A-G intron -    22484847 chr2:178079468(+) A-G intron -    22484847 chr2:178079905(+) A-G intron -    22484847 chr2:178079952(+) A-G intron -    22484847 chr2:178079964(+) A-G intron -    22484847 chr2:178082980(+) T-C intron -    22484847 chr2:178087277(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HNRNPA3	chr2:178077426-178077427(+) m6A 5'UTR       24981863 chr2:178077494-178077495(+) m6A 5'UTR       25456834//24981863 chr2:178077538-178077539(+) m6A CDS//intron       25456834//24981863//26404942 chr2:178080283-178080284(+) m6A CDS       24981863//26404942 chr2:178080301-178080302(+) m6A CDS       24981863 chr2:178080329-178080330(+) m6A CDS       24981863//27773535 chr2:178080352-178080353(+) m6A CDS       24981863//27773535 chr2:178080487-178080488(+) m6A CDS       24981863 chr2:178080495-178080496(+) m6A CDS       - chr2:178080599-178080600(+) m6A CDS       27773535 chr2:178080793-178080794(+) m6A CDS       24981863//27773535 chr2:178080822-178080823(+) m6A CDS       24981863//27773535 chr2:178080841-178080842(+) m6A CDS       24981863//27773535 chr2:178081288-178081289(+) m6A CDS       24209618//24981863//27773535 chr2:178081445-178081446(+) m6A CDS       24209618//24981863//27773535//22575960 chr2:178081484-178081485(+) m6A CDS//intron       24209618//24981863//27773535//22575960 chr2:178082490-178082491(+) m6A CDS//intron       24209618//24981863//27773535 chr2:178082504-178082505(+) m6A CDS//intron       24209618//24981863//27773535 chr2:178083785-178083786(+) m6A CDS       24209618//24981863//27773535 chr2:178083813-178083814(+) m6A CDS       24209618//24981863//27773535 chr2:178083834-178083835(+) m6A CDS//exon       24209618//24981863//27773535 chr2:178083864-178083865(+) m1A CDS//exon       26863196 chr2:178084029-178084030(+) m6A 3'UTR//exon       24209618//24981863//27773535//22575960 chr2:178084088-178084089(+) m6A 3'UTR//exon//intron       24209618//24981863//27773535//22575960 chr2:178084197-178084198(+) m6A 3'UTR//exon       24209618//24981863//27773535//22608085 chr2:178084223-178084224(+) m6A 3'UTR//exon       24209618//24981863//27773535//22608085 chr2:178084285-178084286(+) m6A 3'UTR//exon       24209618//24981863//22608085 chr2:178084292-178084293(+) m6A 3'UTR//exon       24209618//24981863//22608085 chr2:178084308-178084309(+) m6A 3'UTR//exon       24981863 chr2:178084685-178084686(+) Y 3'UTR       26075521 chr2:178085012-178085013(+) Y 3'UTR       26075521 chr2:178085856-178085857(+) m6A 3'UTR       27773535 chr2:178085873-178085874(+) m6A 3'UTR       27773535 chr2:178085979-178085980(+) m6A 3'UTR       27773535 chr2:178086003-178086004(+) m6A 3'UTR       27773535 chr2:178086324-178086325(+) m6A 3'UTR       24284625//24981863//22608085 chr2:178086375-178086376(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr2:178086415-178086416(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr2:178086425-178086426(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:178086430-178086431(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:178086454-178086455(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:178086630-178086631(+) m6A 3'UTR       27773535//22608085 chr2:178086676-178086677(+) m6A 3'UTR       27773535//22608085 chr2:178087189-178087190(+) m6A 3'UTR       26404942 chr2:178087222-178087223(+) m6A 3'UTR       26404942 chr2:178087236-178087237(+) m6A 3'UTR       26404942 chr2:178087831-178087832(+) m6A 3'UTR       27773535 chr2:178087923-178087924(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-101-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	HNRNPA3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-101-5p	Benzothiazole 7222 Drug interaction    RC00006831

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-101-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-5p
Interactor2: HNRNPA3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).