Detail Information

Basic Information:


  VIRBase ID:  

HHID00009614

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           PAQR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p PAQR3
miRBase
Accession/Entrez ID		 MIMAT0004513 152559
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - RKTG

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PAQR3
chr4:79839157(-) A-I      3'UTR
chr4:79839152(-) A-I      3'UTR
chr4:79839151(-) A-I      3'UTR
chr4:79839144(-) A-I      3'UTR
chr4:79839143(-) A-I      3'UTR
chr4:79839194(-) A-I      3'UTR
chr4:79839198(-) A-I      3'UTR
chr4:79839158(-) A-I      3'UTR
chr4:79839131(-) A-I      3'UTR
chr4:79814994(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PAQR3
chr4:79832156-79832157(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085
chr4:79832263-79832264(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:79832282-79832283(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr4:79832353-79832354(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:79832635-79832636(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79832668-79832669(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79832873-79832874(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79832993-79832994(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833121-79833122(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833130-79833131(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr4:79833220-79833221(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79833240-79833241(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr4:79860422-79860423(-) m6A 5'UTR       24209618//27371828//27773536
chr4:79860492-79860493(-) m6A 5'UTR       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PAQR3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: PAQR3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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