Detail Information

Basic Information:


  VIRBase ID:  

HHID00009580

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           MBOAT2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p MBOAT2
miRBase
Accession/Entrez ID		 MIMAT0004513 129642
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LPAAT//LPCAT//LPCAT4//LPEAT//LPLAT 2//OACT2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MBOAT2
chr2:9103291(-) A-I      intronic
chr2:9103201(-) A-I      intronic
chr2:9007420(-) A-I      intronic
chr2:9007374(-) A-I      intronic
chr2:9103304(-) A-I      intronic
chr2:9007393(-) A-I      intronic
chr2:9007419(-) A-I      intronic
chr2:9007414(-) A-I      intronic
chr2:9103610(-) A-I      intronic
chr2:9103606(-) A-I      intronic
chr2:9103597(-) A-I      intronic
chr2:9103571(-) A-I      intronic
chr2:9103570(-) A-I      intronic
chr2:9103310(-) A-I      intronic
chr2:9103233(-) A-I      intronic
chr2:9103127(-) A-I      intronic
chr2:9080694(-) A-I      intronic
chr2:9018728(-) A-I      intronic
chr2:9018720(-) A-I      intronic
chr2:9018736(-) A-I      intronic
chr2:9080526(-) A-I      intronic
chr2:9080549(-) A-I      intronic
chr2:9007426(-) A-I      intronic
chr2:9005970(-) A-I      intronic
chr2:9007320(-) A-I      intronic
chr2:9103333(-) A-I      intronic
chr2:9007311(-) A-I      intronic
chr2:8996686(-) A-I      3'UTR
chr2:9096739(-) A-I      intronic
chr2:9103272(-) A-I      intronic
chr2:9006018(-) A-I      intronic
chr2:9099867(-) A-I      intronic
chr2:9030883(-) A-I      intronic
chr2:9103584(-) A-I      intronic
chr2:9103154(-) A-I      intronic
chr2:9103449(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MBOAT2
chr2:9084095(-) A-G intron -    22484847
chr2:9103154(-) A-G intron -    22484847
chr2:9103272(-) A-G intron -    22484847
chr2:9103281(-) A-G intron -    22484847
chr2:9103333(-) A-G intron -    22484847
chr2:9103584(-) A-G intron -    22484847
chr2:9103682(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MBOAT2
chr2:8997884-8997885(-) m6A 3'UTR       24284625//24981863//22608085
chr2:8997922-8997923(-) m6A 3'UTR       24981863//22608085
chr2:8998645-8998646(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr2:8998695-8998696(-) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr2:8998761-8998762(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22608085
chr2:8998829-8998830(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27371828//22608085
chr2:8998866-8998867(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr2:8998884-8998885(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr2:8998889-8998890(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr2:8998941-8998942(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr2:8998969-8998970(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MBOAT2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: MBOAT2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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