Detail Information

Basic Information:


  VIRBase ID:  

HHID00009508

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           ANP32E:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p ANP32E
miRBase
Accession/Entrez ID		 MIMAT0004513 81611
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LANP-L//LANPL

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANP32E
chr1:150198523(-) A-I      intronic
chr1:150203258(-) A-I      intronic
chr1:150202413(-) A-I      intronic
chr1:150201877(-) A-I      intronic
chr1:150201744(-) A-I      intronic
chr1:150201743(-) A-I      intronic
chr1:150200977(-) A-I      intronic
chr1:150200938(-) A-I      intronic
chr1:150198585(-) A-I      intronic
chr1:150205488(-) A-I      intronic
chr1:150205447(-) A-I      intronic
chr1:150205399(-) A-I      intronic
chr1:150203849(-) A-I      intronic
chr1:150203345(-) A-I      intronic
chr1:150193391(-) A-I      intronic
chr1:150195945(-) A-I      intronic
chr1:150196135(-) A-I      intronic
chr1:150196140(-) A-I      intronic
chr1:150196237(-) A-I      intronic
chr1:150196251(-) A-I      intronic
chr1:150196254(-) A-I      intronic
chr1:150196708(-) A-I      intronic
chr1:150197851(-) A-I      intronic
chr1:150197961(-) A-I      intronic
chr1:150198403(-) A-I      intronic
chr1:150198443(-) A-I      intronic
chr1:150198501(-) A-I      intronic
chr1:150198505(-) A-I      intronic
chr1:150198512(-) A-I      intronic
chr1:150198516(-) A-I      intronic
chr1:150198554(-) A-I      intronic
chr1:150198584(-) A-I      intronic
chr1:150196643(-) A-I      intronic
chr1:150198493(-) A-I      intronic
chr1:150204894(-) A-I      intronic
chr1:150196361(-) A-I      intronic
chr1:150197832(-) A-I      intronic
chr1:150196345(-) A-I      intronic
chr1:150203739(-) A-I      intronic
chr1:150203761(-) A-I      intronic
chr1:150194277(-) A-I      intronic
chr1:150194173(-) A-I      intronic
chr1:150203855(-) A-I      intronic
chr1:150194984(-) A-I      intronic
chr1:150195841(-) A-I      intronic
chr1:150198618(-) A-I      intronic
chr1:150205430(-) A-I      intronic
chr1:150195759(-) A-I      intronic
chr1:150205453(-) A-I      intronic
chr1:150193370(-) A-I      intronic
chr1:150196344(-) A-I      intronic
chr1:150198481(-) A-I      intronic
chr1:150203219(-) A-I      intronic
chr1:150195080(-) A-I      intronic
chr1:150193355(-) A-I      intronic
chr1:150195028(-) A-I      intronic
chr1:150198475(-) A-I      intronic
chr1:150195850(-) A-I      intronic
chr1:150198568(-) A-I      intronic
chr1:150195002(-) A-I      intronic
chr1:150198611(-) A-I      intronic
chr1:150195931(-) A-I      intronic
chr1:150195750(-) A-I      intronic
chr1:150203838(-) A-I      intronic
chr1:150203192(-) A-I      intronic
chr1:150195960(-) A-I      intronic
chr1:150198434(-) A-I      intronic
chr1:150196304(-) A-I      intronic
chr1:150204901(-) A-I      intronic
chr1:150198465(-) A-I      intronic
chr1:150197741(-) A-I      intronic
chr1:150203299(-) A-I      intronic
chr1:150198440(-) A-I      intronic
chr1:150198513(-) A-I      intronic
chr1:150195955(-) A-I      intronic
chr1:150195790(-) A-I      intronic
chr1:150203218(-) A-I      intronic
chr1:150203259(-) A-I      intronic
chr1:150193341(-) A-I      intronic
chr1:150196789(-) A-I      intronic
chr1:150198612(-) A-I      intronic
chr1:150196285(-) A-I      intronic
chr1:150205510(-) A-I      intronic
chr1:150197937(-) A-I      intronic
chr1:150197913(-) A-I      intronic
chr1:150201849(-) A-I      intronic
chr1:150197952(-) A-I      intronic
chr1:150201729(-) A-I      intronic
chr1:150194852(-) A-I      intronic
chr1:150200817(-) A-I      intronic
chr1:150195762(-) A-I      intronic
chr1:150195907(-) A-I      intronic
chr1:150203254(-) A-I      intronic
chr1:150195061(-) A-I      intronic
chr1:150198510(-) A-I      intronic
chr1:150196318(-) A-I      intronic
chr1:150204908(-) A-I      intronic
chr1:150196695(-) A-I      intronic
chr1:150201910(-) A-I      intronic
chr1:150195859(-) A-I      intronic
chr1:150197826(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ANP32E
chr1:150194425(-) C-T intron -    22484847
chr1:150194430(-) T-C intron -    22484847
chr1:150195762(-) A-G intron -    22484847
chr1:150195841(-) A-G intron -    22484847
chr1:150195850(-) A-G intron -    22484847
chr1:150195859(-) A-G intron -    22484847
chr1:150195907(-) A-G intron -    22484847
chr1:150195955(-) A-G intron -    22484847
chr1:150197826(-) A-G intron -    22484847
chr1:150198440(-) A-G intron -    22484847
chr1:150198493(-) A-G intron -    22484847
chr1:150201631(-) G-A intron -    22484847
chr1:150203192(-) A-G intron -    22484847
chr1:150203218(-) A-G intron -    22484847
chr1:150203219(-) A-G intron -    22484847
chr1:150203254(-) A-G intron -    22484847
chr1:150203259(-) A-G intron -    22484847
chr1:150203299(-) A-G intron -    22484847
chr1:150203761(-) A-G intron -    22484847
chr1:150203838(-) A-G intron -    22484847
chr1:150204818(-) G-A intron -    22484847
chr1:150204894(-) A-G intron -    22484847
chr1:150204901(-) A-G intron -    22484847
chr1:150204908(-) A-G intron -    22484847
chr1:150205430(-) A-G intron -    22484847
chr1:150205453(-) A-G intron -    22484847
chr1:150205510(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANP32E
chr1:150191135-150191136(-) Y 3'UTR       25219674
chr1:150191900-150191901(-) m6A 3'UTR       24981863
chr1:150191974-150191975(-) m6A 3'UTR       24981863
chr1:150192980-150192981(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828
chr1:150193002-150193003(-) m1A 3'UTR//CDS       26863196
chr1:150195516-150195517(-) m1A CDS//intron       26863196
chr1:150195525-150195526(-) m1A CDS//intron       26863196
chr1:150195534-150195535(-) m1A CDS//intron       26863196
chr1:150195558-150195559(-) m1A CDS//intron       26863196
chr1:150195586-150195587(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr1:150201427-150201428(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr1:150201486-150201487(-) m6A CDS//intron       24209618//24981863//27773535
chr1:150201517-150201518(-) m6A CDS//intron       24981863//27773535
chr1:150208096-150208097(-) m6A CDS       24209618//24981863//28052920//27773535//22575960
chr1:150208121-150208122(-) m1A CDS       26863410//26863196
chr1:150208135-150208136(-) m6A 5'UTR       24209618//24981863//27773535//22575960
chr1:150208308-150208309(-) m6A 5'UTR//intron       24209618//24981863//27773535
chr1:150208350-150208351(-) m6A 5'UTR//intron       24209618//24981863//27773535
chr1:150208429-150208430(-) m6A 5'UTR       24284625//24209618//24981863//28052920//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ANP32E
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: ANP32E

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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