Detail Information

Basic Information:


  VIRBase ID:  

HHID00009503

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           PRR3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p PRR3
miRBase
Accession/Entrez ID		 MIMAT0004513 80742
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CAT56

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRR3
chr6:30524674-30524675(+) m6A 5'UTR       -
chr6:30524680-30524681(+) m6A 5'UTR       -
chr6:30524743-30524744(+) m6A 5'UTR       24284625//24981863//22608085
chr6:30525054-30525055(+) m6A 5'UTR       24284625//25456834//24981863//22608085
chr6:30525116-30525117(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085
chr6:30525196-30525197(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085
chr6:30525969-30525970(+) m6A CDS//exon//intron       24284625//25456834//24981863//22608085
chr6:30529110-30529111(+) m6A exon//intron       24284625
chr6:30529180-30529181(+) m6A exon//intron       24284625//24209618//24981863//22608085
chr6:30529205-30529206(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:30529240-30529241(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:30529266-30529267(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:30529282-30529283(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:30529314-30529315(+) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:30529324-30529325(+) m6A exon//intron       24284625//24981863//22608085
chr6:30529641-30529642(+) m6A CDS//exon       24284625
chr6:30529761-30529762(+) m6A CDS//exon       24284625
chr6:30529818-30529819(+) m6A CDS//exon       24284625
chr6:30529826-30529827(+) m6A CDS//exon       24284625
chr6:30530225-30530226(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085
chr6:30530259-30530260(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085
chr6:30530273-30530274(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085
chr6:30530486-30530487(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr6:30530499-30530500(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr6:30530563-30530564(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:30530570-30530571(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr6:30530737-30530738(+) m6A 3'UTR//exon       24284625//27773535
chr6:30530894-30530895(+) m6A 3'UTR//exon       24284625//24209618//27773535//22608085
chr6:30531003-30531004(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr6:30531036-30531037(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr6:30531048-30531049(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr6:30531105-30531106(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr6:30531177-30531178(+) m6A 3'UTR//exon       24284625//27773535
chr6:30531257-30531258(+) m6A 3'UTR//exon       24284625//27773535
chr6:30531323-30531324(+) m6A 3'UTR//exon       27773535
chr6:30531333-30531334(+) m6A 3'UTR//exon       27773535
chr6:30531349-30531350(+) m6A 3'UTR//exon       27773535
chr6:30531414-30531415(+) m6A 3'UTR//exon       24981863
chr6:30531483-30531484(+) m6A 3'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PRR3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: PRR3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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