Detail Information

Basic Information:


  VIRBase ID:  

HHID00009470

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           USP46:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p USP46
miRBase
Accession/Entrez ID		 MIMAT0004513 64854
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR USP46
chr4:53472550(-) A-I      intronic
chr4:53506806(-) A-I      intronic
chr4:53506854(-) A-I      intronic
chr4:53502810(-) A-I      intronic
chr4:53502688(-) A-I      intronic
chr4:53500780(-) A-I      intronic
chr4:53500768(-) A-I      intronic
chr4:53500759(-) A-I      intronic
chr4:53482748(-) A-I      intronic
chr4:53482735(-) A-I      intronic
chr4:53472549(-) A-I      intronic
chr4:53472517(-) A-I      intronic
chr4:53472534(-) A-I      intronic
chr4:53472548(-) A-I      intronic
chr4:53503074(-) A-I      intronic
chr4:53503061(-) A-I      intronic
chr4:53502790(-) A-I      intronic
chr4:53500441(-) A-I      intronic
chr4:53502787(-) A-I      intronic
chr4:53503178(-) A-I      intronic
chr4:53500484(-) A-I      intronic
chr4:53502761(-) A-I      intronic
chr4:53505966(-) A-I      intronic
chr4:53520771(-) A-I      intronic
chr4:53506861(-) A-I      intronic
chr4:53503147(-) A-I      intronic
chr4:53506887(-) A-I      intronic
chr4:53500864(-) A-I      intronic
chr4:53503150(-) A-I      intronic
chr4:53503015(-) A-I      intronic
chr4:53503116(-) A-I      intronic
chr4:53505992(-) A-I      intronic
chr4:53503045(-) A-I      intronic
chr4:53500455(-) A-I      intronic
chr4:53503098(-) A-I      intronic
chr4:53502773(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED USP46
chr4:53500864(-) A-G intron -    22484847
chr4:53502761(-) A-G intron -    22484847
chr4:53502787(-) A-G intron -    22484847
chr4:53502790(-) A-G intron -    22484847
chr4:53506861(-) A-G intron -    22484847
chr4:53506887(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase USP46
chr4:53457140-53457141(-) m6A 3'UTR       27773535
chr4:53457197-53457198(-) m6A 3'UTR       27773535
chr4:53457329-53457330(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457368-53457369(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457383-53457384(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457508-53457509(-) m6A 3'UTR       27773535
chr4:53457514-53457515(-) m6A 3'UTR       27773535
chr4:53461038-53461039(-) m6A 3'UTR       24981863//22608085
chr4:53461486-53461487(-) m6A 3'UTR       24981863
chr4:53462268-53462269(-) m6A 3'UTR       24981863
chr4:53462298-53462299(-) m6A 3'UTR       24981863//22608085
chr4:53462371-53462372(-) m6A 3'UTR       24981863//22608085
chr4:53462389-53462390(-) m6A 3'UTR       24981863//22608085
chr4:53462397-53462398(-) m6A 3'UTR       24981863//22608085
chr4:53462431-53462432(-) m6A 3'UTR       24981863//22608085
chr4:53462438-53462439(-) m6A 3'UTR       24981863//22608085
chr4:53463669-53463670(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085
chr4:53463788-53463789(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085
chr4:53463797-53463798(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
USP46
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: USP46

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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