Detail Information

Basic Information:


  VIRBase ID:  

HHID00009411

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           RBM22:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p RBM22
miRBase
Accession/Entrez ID		 MIMAT0004513 55696
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Cwc2//fSAP47//ZC3H16

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RBM22
chr5:150079117(-) A-I      intronic
chr5:150074622(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RBM22
chr5:150074685(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RBM22
chr5:150070515-150070516(-) m6A 3'UTR//exon       24981863//26404942//22575960//22608085
chr5:150070569-150070570(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr5:150070585-150070586(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr5:150070597-150070598(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr5:150070629-150070630(-) m6A 3'UTR//exon       24284625//24981863//26404942//22608085
chr5:150070664-150070665(-) m6A 3'UTR//exon       24284625//24981863//26404942//22608085
chr5:150070707-150070708(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr5:150070806-150070807(-) m6A 3'UTR//exon       24981863//27773535
chr5:150070940-150070941(-) m6A 3'UTR//exon       27773535
chr5:150071045-150071046(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:150071078-150071079(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:150071134-150071135(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:150071177-150071178(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr5:150071265-150071266(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr5:150071327-150071328(-) m6A CDS//exon       24284625//24209618//27773535
chr5:150071358-150071359(-) m6A CDS//exon       24284625//24209618//27773535
chr5:150071381-150071382(-) m6A CDS//exon       24284625//24209618//27773535
chr5:150071411-150071412(-) m6A CDS//exon       24284625//24209618//27773535
chr5:150072503-150072504(-) m6A CDS//exon       24284625//27773535//27371828//27773536
chr5:150072802-150072803(-) m6A CDS//exon       24284625//27773535//27371828//27773536
chr5:150072808-150072809(-) m6A CDS//exon       24284625//27773535//27371828//27773536
chr5:150072821-150072822(-) m6A CDS//exon       27773535
chr5:150072828-150072829(-) m6A CDS//exon       27773535
chr5:150073657-150073658(-) m6A CDS//exon       27773535
chr5:150080426-150080427(-) m6A CDS//intron       27371828//27773536
chr5:150080506-150080507(-) m6A CDS//exon       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
RBM22
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: RBM22

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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