Basic Information:

  VIRBase ID:  

HHID00009356

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:  MIMAT0004513          SUCO:  NM_016227     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-5p	SUCO
miRBase Accession/Entrez ID	MIMAT0004513	51430
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C1orf9//CH1//OPT//SLP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-5p	rs1200170859 chr1:65058478    G/C rs548109012 chr1:65058477    A/G rs548109012 chr1:65058477    A/T rs1235943983 chr1:65058493    T/C rs746487797 chr1:65058492    A/G rs777575128 chr1:65058491    G/C rs777575128 chr1:65058491    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SUCO	chr1:172515215(+) A-I      intronic chr1:172515991(+) A-I      intronic chr1:172515188(+) A-I      intronic chr1:172515902(+) A-I      intronic chr1:172515873(+) A-I      intronic chr1:172515848(+) A-I      intronic chr1:172515934(+) A-I      intronic chr1:172550088(+) A-I      intronic chr1:172515878(+) A-I      intronic chr1:172515969(+) A-I      intronic chr1:172515151(+) A-I      intronic chr1:172515889(+) A-I      intronic chr1:172570554(+) A-I      intronic chr1:172515928(+) A-I      intronic chr1:172553674(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SUCO	chr1:172501746-172501747(+) m6A CDS       27773535 chr1:172501766-172501767(+) m6A CDS       27773535 chr1:172501813-172501814(+) m6A CDS       27773535 chr1:172502464-172502465(+) m6A 5'UTR//CDS       - chr1:172558040-172558041(+) m6A CDS       24981863//22608085 chr1:172558077-172558078(+) m6A CDS//intron       24981863//22608085 chr1:172558097-172558098(+) m6A CDS//intron       24981863//22608085 chr1:172558188-172558189(+) m6A CDS//intron       24981863//22608085 chr1:172558326-172558327(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr1:172558400-172558401(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558406-172558407(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558422-172558423(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr1:172558514-172558515(+) m6A CDS//intron       24284625//24981863//22608085 chr1:172558569-172558570(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558574-172558575(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558607-172558608(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558626-172558627(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr1:172558675-172558676(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr1:172558707-172558708(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr1:172558794-172558795(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22608085 chr1:172558847-172558848(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr1:172558887-172558888(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr1:172558966-172558967(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr1:172558991-172558992(+) m6A CDS//intron       24981863//22608085 chr1:172559047-172559048(+) Y CDS//intron       26075521 chr1:172577914-172577915(+) m6A CDS//exon       22608085 chr1:172578991-172578992(+) m6A CDS//exon       22608085 chr1:172579008-172579009(+) m6A CDS//exon       22608085 chr1:172579061-172579062(+) m6A CDS//exon       24284625//24981863//22608085 chr1:172579138-172579139(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr1:172579203-172579204(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579216-172579217(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579222-172579223(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579265-172579266(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579285-172579286(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579297-172579298(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579343-172579344(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579363-172579364(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579389-172579390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579409-172579410(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:172579425-172579426(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr1:172579451-172579452(+) m6A 3'UTR       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-101-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	SUCO	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-101-5p	Benzothiazole 7222 Drug interaction    RC00006831

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-101-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-5p
Interactor2: SUCO

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).