Detail Information

Basic Information:


  VIRBase ID:  

HHID00009320

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           TMEM97:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p TMEM97
miRBase
Accession/Entrez ID		 MIMAT0004513 27346
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MAC30//sigma2R

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM97
chr17:26654244(+) A-I      3'UTR
chr17:26654249(+) A-I      3'UTR
chr17:26650903(+) A-I      intronic
chr17:26650566(+) A-I      intronic
chr17:26650806(+) A-I      intronic
chr17:26654225(+) A-I      3'UTR
chr17:26654121(+) A-I      3'UTR
chr17:26654072(+) A-I      3'UTR
chr17:26650558(+) A-I      intronic
chr17:26654271(+) A-I      3'UTR
chr17:26654232(+) A-I      3'UTR
chr17:26654117(+) A-I      3'UTR
chr17:26654113(+) A-I      3'UTR
chr17:26654008(+) A-I      3'UTR
chr17:26650987(+) A-I      intronic
chr17:26650705(+) A-I      intronic
chr17:26650965(+) A-I      intronic
chr17:26654127(+) A-I      3'UTR
chr17:26654137(+) A-I      3'UTR
chr17:26654231(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM97
chr17:26654232(+) A-I intron -    21960545
chr17:26654113(+) A-G intron -    22484847
chr17:26654121(+) A-G intron -    22484847
chr17:26654137(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM97
chr17:26652535-26652536(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652568-26652569(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652829-26652830(+) m6A 3'UTR//intron       24284625//24209618//22608085
chr17:26653579-26653580(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653680-26653681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653686-26653687(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653693-26653694(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653824-26653825(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653887-26653888(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653899-26653900(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653924-26653925(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653963-26653964(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26653973-26653974(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654009-26654010(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654123-26654124(+) m6A 3'UTR       24209618//24981863
chr17:26654183-26654184(+) m6A 3'UTR       24209618
chr17:26654280-26654281(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654299-26654300(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26654328-26654329(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr17:26654436-26654437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654441-26654442(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654448-26654449(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654459-26654460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654520-26654521(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26655132-26655133(+) m6A 3'UTR       27773535
chr17:26655361-26655362(+) m6A 3'UTR       27773535
chr17:26655428-26655429(+) m6A 3'UTR       27773535
chr17:26655508-26655509(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr17:26655522-26655523(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TMEM97
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: TMEM97

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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