Detail Information

Basic Information:


  VIRBase ID:  

HHID00009294

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           TTC33:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p TTC33
miRBase
Accession/Entrez ID		 MIMAT0004513 23548
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - OSRF

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TTC33
chr5:40745952(-) A-I      intronic
chr5:40743775(-) A-I      intronic
chr5:40743753(-) A-I      intronic
chr5:40732936(-) A-I      intronic
chr5:40732849(-) A-I      intronic
chr5:40732816(-) A-I      intronic
chr5:40728334(-) A-I      intronic
chr5:40745953(-) A-I      intronic
chr5:40728324(-) A-I      intronic
chr5:40728140(-) A-I      intronic
chr5:40722303(-) A-I      intronic
chr5:40725142(-) A-I      intronic
chr5:40725150(-) A-I      intronic
chr5:40718794(-) A-I      intronic
chr5:40718793(-) A-I      intronic
chr5:40718679(-) A-I      intronic
chr5:40717209(-) A-I      intronic
chr5:40745981(-) A-I      intronic
chr5:40749146(-) A-I      intronic
chr5:40726159(-) A-I      intronic
chr5:40725302(-) A-I      intronic
chr5:40743800(-) A-I      intronic
chr5:40725370(-) A-I      intronic
chr5:40737194(-) A-I      intronic
chr5:40725087(-) A-I      intronic
chr5:40751996(-) A-I      intronic
chr5:40728340(-) A-I      intronic
chr5:40725051(-) A-I      intronic
chr5:40748162(-) A-I      intronic
chr5:40725131(-) A-I      intronic
chr5:40725222(-) A-I      intronic
chr5:40749141(-) A-I      intronic
chr5:40743709(-) A-I      intronic
chr5:40728166(-) A-I      intronic
chr5:40743707(-) A-I      intronic
chr5:40725153(-) A-I      intronic
chr5:40725113(-) A-I      intronic
chr5:40728196(-) A-I      intronic
chr5:40725316(-) A-I      intronic
chr5:40748095(-) A-I      intronic
chr5:40745733(-) A-I      intronic
chr5:40725177(-) A-I      intronic
chr5:40728139(-) A-I      intronic
chr5:40728323(-) A-I      intronic
chr5:40728264(-) A-I      intronic
chr5:40725152(-) A-I      intronic
chr5:40725117(-) A-I      intronic
chr5:40725182(-) A-I      intronic
chr5:40742028(-) A-I      intronic
chr5:40725356(-) A-I      intronic
chr5:40726160(-) A-I      intronic
chr5:40728227(-) A-I      intronic
chr5:40728127(-) A-I      intronic
chr5:40743712(-) A-I      intronic
chr5:40728201(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TTC33
chr5:40728196(-) A-G intron -    22484847
chr5:40728227(-) A-G intron -    22484847
chr5:40728323(-) A-G intron -    22484847
chr5:40748095(-) A-G intron -    22484847
chr5:40748162(-) A-G intron -    22484847
chr5:40748436(-) A-G intron -    22484847
chr5:40749141(-) A-G intron -    22484847
chr5:40751930(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TTC33
chr5:40716111-40716112(-) m6A 3'UTR//exon       26404942//27773535
chr5:40716181-40716182(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr5:40716311-40716312(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr5:40716347-40716348(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr5:40716365-40716366(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr5:40716427-40716428(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr5:40716535-40716536(-) m6A CDS//exon       24209618//24981863//27773535//22608085
chr5:40716556-40716557(-) m6A CDS//exon       24209618//24981863//27773535//22608085
chr5:40728487-40728488(-) m6A CDS//exon//intron       27773535
chr5:40746940-40746941(-) m6A CDS//exon       24981863//27773535
chr5:40747004-40747005(-) m6A CDS//exon       24981863//27773535
chr5:40755946-40755947(-) m6A 5'UTR//exon       24981863//27773535//27371828
chr5:40755962-40755963(-) m6A 5'UTR//exon       24981863//27773535//27371828
chr5:40755990-40755991(-) m6A 5'UTR//exon       25456834//24981863//27773535//27371828
chr5:40756023-40756024(-) m6A 5'UTR//exon       25456834//24981863//27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TTC33
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: TTC33

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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