Basic Information:

  VIRBase ID:  

HHID00009278

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:  MIMAT0004513          MTF2:  NM_001164393     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-5p	MTF2
miRBase Accession/Entrez ID	MIMAT0004513	22823
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ976O13.2//M96//PCL2//TDRD19A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-5p	rs1200170859 chr1:65058478    G/C rs548109012 chr1:65058477    A/G rs548109012 chr1:65058477    A/T rs1235943983 chr1:65058493    T/C rs746487797 chr1:65058492    A/G rs777575128 chr1:65058491    G/C rs777575128 chr1:65058491    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTF2	chr1:93551899(+) A-I      intronic chr1:93600183(+) A-I      intronic chr1:93551920(+) A-I      intronic chr1:93551903(+) A-I      intronic chr1:93601271(+) A-I      intronic chr1:93551910(+) A-I      intronic chr1:93600161(+) A-I      intronic chr1:93551177(+) A-I      intronic chr1:93551183(+) A-I      intronic chr1:93601320(+) A-I      intronic chr1:93601301(+) A-I      intronic chr1:93601210(+) A-I      intronic chr1:93601180(+) A-I      intronic chr1:93600218(+) A-I      intronic chr1:93600168(+) A-I      intronic chr1:93600167(+) A-I      intronic chr1:93581748(+) A-I      intronic chr1:93569608(+) A-I      intronic chr1:93565979(+) A-I      intronic chr1:93565966(+) A-I      intronic chr1:93565955(+) A-I      intronic chr1:93555663(+) A-I      intronic chr1:93558506(+) A-I      intronic chr1:93555740(+) A-I      intronic chr1:93558579(+) A-I      intronic chr1:93558576(+) A-I      intronic chr1:93555595(+) A-I      intronic chr1:93555592(+) A-I      intronic chr1:93565942(+) A-I      intronic chr1:93550306(+) A-I      intronic chr1:93550346(+) A-I      intronic chr1:93550354(+) A-I      intronic chr1:93550813(+) A-I      intronic chr1:93550862(+) A-I      intronic chr1:93550936(+) A-I      intronic chr1:93593851(+) A-I      intronic chr1:93600208(+) A-I      intronic chr1:93569983(+) A-I      intronic chr1:93569625(+) A-I      intronic chr1:93593953(+) A-I      intronic chr1:93551820(+) A-I      intronic chr1:93601158(+) A-I      intronic chr1:93569570(+) A-I      intronic chr1:93567156(+) A-I      intronic chr1:93570115(+) A-I      intronic chr1:93583310(+) A-I      intronic chr1:93554307(+) A-I      intronic chr1:93600343(+) A-I      intronic chr1:93568098(+) A-I      intronic chr1:93570116(+) A-I      intronic chr1:93582336(+) A-I      intronic chr1:93593877(+) A-I      intronic chr1:93593950(+) A-I      intronic chr1:93600146(+) A-I      intronic chr1:93555522(+) A-I      intronic chr1:93582187(+) A-I      intronic chr1:93601266(+) A-I      intronic chr1:93601166(+) A-I      intronic chr1:93600186(+) A-I      intronic chr1:93600316(+) A-I      intronic chr1:93583471(+) A-I      intronic chr1:93600546(+) A-I      intronic chr1:93601141(+) A-I      intronic chr1:93551805(+) A-I      intronic chr1:93601283(+) A-I      intronic chr1:93600185(+) A-I      intronic chr1:93601136(+) A-I      intronic chr1:93593955(+) A-I      intronic chr1:93550919(+) A-I      intronic chr1:93601211(+) A-I      intronic chr1:93600130(+) A-I      intronic chr1:93571333(+) A-I      intronic chr1:93559345(+) A-I      intronic chr1:93551942(+) A-I      intronic chr1:93560608(+) A-I      intronic chr1:93600243(+) A-I      intronic chr1:93600693(+) A-I      intronic chr1:93581715(+) A-I      intronic chr1:93570459(+) A-I      intronic chr1:93568045(+) A-I      intronic chr1:93567221(+) A-I      intronic chr1:93588888(+) A-I      intronic chr1:93600221(+) A-I      intronic chr1:93559340(+) A-I      intronic chr1:93581714(+) A-I      intronic chr1:93566027(+) A-I      intronic chr1:93581684(+) A-I      intronic chr1:93566076(+) A-I      intronic chr1:93567924(+) A-I      intronic chr1:93600132(+) A-I      intronic chr1:93601157(+) A-I      intronic chr1:93594035(+) A-I      intronic chr1:93600113(+) A-I      intronic chr1:93572146(+) A-I      intronic chr1:93555519(+) A-I      intronic chr1:93593905(+) A-I      intronic chr1:93582294(+) A-I      intronic chr1:93569982(+) A-I      intronic chr1:93600238(+) A-I      intronic chr1:93583529(+) A-I      intronic chr1:93550872(+) A-I      intronic chr1:93556966(+) A-I      intronic chr1:93551231(+) A-I      intronic chr1:93601265(+) A-I      intronic chr1:93555352(+) A-I      intronic chr1:93550332(+) A-I      intronic chr1:93601338(+) A-I      intronic chr1:93601133(+) A-I      intronic chr1:93569575(+) A-I      intronic chr1:93569725(+) A-I      intronic chr1:93563255(+) A-I      intronic chr1:93550850(+) A-I      intronic chr1:93600125(+) A-I      intronic chr1:93601262(+) A-I      intronic chr1:93569635(+) A-I      intronic chr1:93551943(+) A-I      intronic chr1:93600105(+) A-I      intronic chr1:93552001(+) A-I      intronic chr1:93568131(+) A-I      intronic chr1:93601212(+) A-I      intronic chr1:93551879(+) A-I      intronic chr1:93601248(+) A-I      intronic chr1:93593954(+) A-I      intronic chr1:93551901(+) A-I      intronic chr1:93600639(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTF2	chr1:93585654(+) A-I intron -    15258596 chr1:93585656(+) A-I intron -    15258596 chr1:93585664(+) A-I intron -    15258596 chr1:93593851(+) A-I intron -    15258596 chr1:93593853(+) A-I intron -    15258596 chr1:93593877(+) A-I intron -    15258596 chr1:93593905(+) A-I intron -    15258596 chr1:93593950(+) A-I intron -    15258596 chr1:93593955(+) A-I intron -    15258596 chr1:93551943(+) A-I intron -    22327324 chr1:93600105(+) A-I intron -    22327324 chr1:93601166(+) A-I intron -    22327324 chr1:93601266(+) A-I intron -    22327324 chr1:93550332(+) A-G intron -    22484847 chr1:93550844(+) T-C intron -    22484847 chr1:93550850(+) A-G intron -    22484847 chr1:93550872(+) A-G intron -    22484847 chr1:93550919(+) A-G intron -    22484847 chr1:93551053(+) C-T intron -    22484847 chr1:93551231(+) A-G intron -    22484847 chr1:93551820(+) A-G intron -    22484847 chr1:93551848(+) G-C intron -    22484847 chr1:93551879(+) A-G intron -    22484847 chr1:93551901(+) A-G intron -    22484847 chr1:93551942(+) A-G intron -    22484847 chr1:93551943(+) A-G intron -    22484847 chr1:93567924(+) A-G intron -    22484847 chr1:93568131(+) A-G intron -    22484847 chr1:93569570(+) A-G intron -    22484847 chr1:93569982(+) A-G intron -    22484847 chr1:93569983(+) A-G intron -    22484847 chr1:93570115(+) A-G intron -    22484847 chr1:93570116(+) A-G intron -    22484847 chr1:93570700(+) C-A intron -    22484847 chr1:93572146(+) A-G intron -    22484847 chr1:93581715(+) A-G intron -    22484847 chr1:93582294(+) A-G intron -    22484847 chr1:93582336(+) A-G intron -    22484847 chr1:93600105(+) A-G intron -    22484847 chr1:93600130(+) A-G intron -    22484847 chr1:93600208(+) A-G intron -    22484847 chr1:93600238(+) A-G intron -    22484847 chr1:93600243(+) A-G intron -    22484847 chr1:93600639(+) A-G intron -    22484847 chr1:93601166(+) A-G intron -    22484847 chr1:93601172(+) C-T intron -    22484847 chr1:93601211(+) A-G intron -    22484847 chr1:93601212(+) A-G intron -    22484847 chr1:93601248(+) A-G intron -    22484847 chr1:93601266(+) A-G intron -    22484847 chr1:93601283(+) A-G intron -    22484847 chr1:93601338(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTF2	chr1:93544851-93544852(+) m6A 5'UTR//exon       24981863 chr1:93544940-93544941(+) m6A 5'UTR//exon       24284625//24981863 chr1:93594862-93594863(+) m1A CDS//exon//intron       26863410 chr1:93594936-93594937(+) m6A CDS//exon//intron       24981863//27773535 chr1:93594946-93594947(+) m6A CDS//exon//intron       24981863//27773535 chr1:93594987-93594988(+) m6A CDS//exon//intron       24981863//27773535 chr1:93599720-93599721(+) m6A CDS//exon       27773535 chr1:93602329-93602330(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr1:93602336-93602337(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:93602351-93602352(+) Am CDS//exon       - chr1:93602388-93602389(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr1:93602417-93602418(+) Cm CDS//exon       - chr1:93602450-93602451(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602591-93602592(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602596-93602597(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr1:93602785-93602786(+) m6A 3'UTR       22608085 chr1:93602791-93602792(+) m6A 3'UTR       22608085 chr1:93602933-93602934(+) m6A 3'UTR       27773535 chr1:93603058-93603059(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-101-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MTF2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-101-5p	Benzothiazole 7222 Drug interaction    RC00006831

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-101-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-5p
Interactor2: MTF2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).