Basic Information:

  VIRBase ID:  

HHID00009195

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:  MIMAT0004513          RIOK3:  NR_145477     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-5p	RIOK3
miRBase Accession/Entrez ID	MIMAT0004513	8780
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SUDD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-5p	rs1200170859 chr1:65058478    G/C rs548109012 chr1:65058477    A/G rs548109012 chr1:65058477    A/T rs1235943983 chr1:65058493    T/C rs746487797 chr1:65058492    A/G rs777575128 chr1:65058491    G/C rs777575128 chr1:65058491    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RIOK3	chr18:21050143(+) A-I      intronic chr18:21050162(+) A-I      intronic chr18:21047881(+) A-I      intronic chr18:21047887(+) A-I      intronic chr18:21047963(+) A-I      intronic chr18:21048004(+) A-I      intronic chr18:21049515(+) A-I      intronic chr18:21040150(+) A-I      intronic chr18:21041934(+) A-I      intronic chr18:21041950(+) A-I      intronic chr18:21042125(+) A-I      intronic chr18:21042221(+) A-I      intronic chr18:21046579(+) A-I      intronic chr18:21047018(+) A-I      intronic chr18:21047113(+) A-I      intronic chr18:21047135(+) A-I      intronic chr18:21047771(+) A-I      intronic chr18:21047866(+) A-I      intronic chr18:21049661(+) A-I      intronic chr18:21049702(+) A-I      intronic chr18:21049711(+) A-I      intronic chr18:21052117(+) A-I      intronic chr18:21059775(+) A-I      intronic chr18:21059776(+) A-I      intronic chr18:21059821(+) A-I      intronic chr18:21060985(+) A-I      intronic chr18:21052035(+) A-I      intronic chr18:21049471(+) A-I      intronic chr18:21052021(+) A-I      intronic chr18:21050232(+) A-I      intronic chr18:21050172(+) A-I      intronic chr18:21050140(+) A-I      intronic chr18:21047107(+) A-I      intronic chr18:21052036(+) A-I      intronic chr18:21052154(+) A-I      intronic chr18:21060933(+) A-I      intronic chr18:21047964(+) A-I      intronic chr18:21041839(+) A-I      intronic chr18:21049593(+) A-I      intronic chr18:21060869(+) A-I      intronic chr18:21049581(+) A-I      intronic chr18:21047854(+) A-I      intronic chr18:21060885(+) A-I      intronic chr18:21046839(+) A-I      intronic chr18:21050169(+) A-I      intronic chr18:21060795(+) A-I      intronic chr18:21060965(+) A-I      intronic chr18:21042270(+) A-I      intronic chr18:21047942(+) A-I      intronic chr18:21060801(+) A-I      intronic chr18:21049508(+) A-I      intronic chr18:21050168(+) A-I      intronic chr18:21050126(+) A-I      intronic chr18:21060897(+) A-I      intronic chr18:21060668(+) A-I      intronic chr18:21060989(+) A-I      intronic chr18:21047198(+) A-I      intronic chr18:21050179(+) A-I      intronic chr18:21042325(+) A-I      intronic chr18:21049626(+) A-I      intronic chr18:21051919(+) A-I      intronic chr18:21060796(+) A-I      intronic chr18:21052076(+) A-I      intronic chr18:21049672(+) A-I      intronic chr18:21050165(+) A-I      intronic chr18:21059007(+) A-I      intronic chr18:21060640(+) A-I      intronic chr18:21059802(+) A-I      intronic chr18:21047267(+) A-I      intronic chr18:21050170(+) A-I      intronic chr18:21050141(+) A-I      intronic chr18:21050219(+) A-I      intronic chr18:21047962(+) A-I      intronic chr18:21059741(+) A-I      intronic chr18:21058294(+) A-I      intronic chr18:21049652(+) A-I      intronic chr18:21060903(+) A-I      intronic chr18:21046507(+) A-I      intronic chr18:21046891(+) A-I      intronic chr18:21060894(+) A-I      intronic chr18:21038066(+) A-I      intronic chr18:21056617(+) A-I      intronic chr18:21051964(+) A-I      intronic chr18:21059815(+) A-I      intronic chr18:21059005(+) A-I      intronic chr18:21059592(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RIOK3	chr18:21059005(+) A-I intron -    15342557 chr18:21061863(+) A-I exon 3'UTR    15342557 chr18:21061910(+) A-I exon 3'UTR    15342557 chr18:21062012(+) A-I exon 3'UTR    15342557 chr18:21062068(+) A-I exon 3'UTR    15342557 chr18:21049591(+) A-I intron -    22327324 chr18:21047854(+) A-I intron -    21960545 chr18:21049546(+) A-G intron -    22484847 chr18:21049581(+) A-G intron -    22484847 chr18:21049591(+) A-G intron -    22484847 chr18:21049593(+) A-G intron -    22484847 chr18:21049652(+) A-G intron -    22484847 chr18:21050165(+) A-G intron -    22484847 chr18:21052146(+) A-G intron -    22484847 chr18:21052154(+) A-G intron -    22484847 chr18:21058270(+) C-T intron -    22484847 chr18:21062476(+) G-A intron -    22484847 chr18:21062477(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RIOK3	chr18:21044214-21044215(+) m6A CDS//exon       24981863 chr18:21044272-21044273(+) m6A CDS//exon       24981863 chr18:21044486-21044487(+) m6A CDS//exon       24981863 chr18:21044543-21044544(+) m6A CDS//exon       24981863 chr18:21044572-21044573(+) m6A CDS//exon       24981863 chr18:21047524-21047525(+) m6A exon//intron       24981863//27773535 chr18:21061331-21061332(+) m6A 3'UTR//exon//intron       27773535 chr18:21061450-21061451(+) m6A 3'UTR//exon//intron       27773535 chr18:21061499-21061500(+) m6A 3'UTR//exon//intron       27773535 chr18:21062026-21062027(+) m6A 3'UTR//exon//intron       27773535 chr18:21062104-21062105(+) m6A 3'UTR//exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-101-5p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	RIOK3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-101-5p	Benzothiazole 7222 Drug interaction    RC00006831

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-101-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-5p
Interactor2: RIOK3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).