Detail Information

Basic Information:


  VIRBase ID:  

HHID00009062

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           LOX:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p LOX
miRBase
Accession/Entrez ID		 MIMAT0004513 4015
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AAT10

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LOX
chr5:121399323-121399324(-) m6A 3'UTR       27773535
chr5:121399903-121399904(-) m6A 3'UTR       27773535
chr5:121399917-121399918(-) m6A 3'UTR       27773535
chr5:121399970-121399971(-) m6A 3'UTR       27773535
chr5:121400002-121400003(-) m6A 3'UTR       27773535
chr5:121400012-121400013(-) m6A 3'UTR       27773535
chr5:121400022-121400023(-) m6A 3'UTR       27773535
chr5:121400071-121400072(-) m6A 3'UTR       27773535
chr5:121400099-121400100(-) m6A 3'UTR       27773535
chr5:121401960-121401961(-) m6A 3'UTR//exon       27773535
chr5:121401990-121401991(-) m6A 3'UTR//exon       27773535
chr5:121402039-121402040(-) m6A 3'UTR//exon       27773535
chr5:121402050-121402051(-) m6A 3'UTR//exon       27773535
chr5:121402069-121402070(-) m6A 3'UTR//exon       27773535
chr5:121402075-121402076(-) m6A 3'UTR//exon       27773535
chr5:121402305-121402306(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402328-121402329(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402335-121402336(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402373-121402374(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr5:121402423-121402424(-) m6A 3'UTR//exon       24981863//22608085
chr5:121411156-121411157(-) m6A 3'UTR//CDS//exon       27773535
chr5:121411164-121411165(-) m6A 3'UTR//CDS//exon       27773535
chr5:121412599-121412600(-) m6A CDS//exon//intron       27773535
chr5:121412771-121412772(-) m6A exon//intron       22608085
chr5:121412894-121412895(-) m6A exon//intron       25456834//24981863//22608085
chr5:121413098-121413099(-) m6A CDS       24284625//24981863//22608085
chr5:121413244-121413245(-) m6A CDS       24284625//24981863//22575960
chr5:121413249-121413250(-) m6A CDS       24284625//24981863//22575960
chr5:121413468-121413469(-) m6A CDS       27773536
chr5:121413531-121413532(-) m6A CDS       27773536
chr5:121413808-121413809(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085
chr5:121413901-121413902(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr5:121413932-121413933(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085
chr5:121413951-121413952(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
LOX
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: LOX

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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