Detail Information

Basic Information:


  VIRBase ID:  

HHID00008976

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-5p:           BLMH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-101-5p BLMH
miRBase
Accession/Entrez ID		 MIMAT0004513 642
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BH//BMH

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-101-5p
rs1200170859 chr1:65058478    G/C
rs548109012 chr1:65058477    A/G
rs548109012 chr1:65058477    A/T
rs1235943983 chr1:65058493    T/C
rs746487797 chr1:65058492    A/G
rs777575128 chr1:65058491    G/C
rs777575128 chr1:65058491    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BLMH
chr17:28582868(-) A-I      intronic
chr17:28597435(-) A-I      intronic
chr17:28601743(-) A-I      intronic
chr17:28601752(-) A-I      intronic
chr17:28601756(-) A-I      intronic
chr17:28601765(-) A-I      intronic
chr17:28608754(-) A-I      intronic
chr17:28606782(-) A-I      intronic
chr17:28607602(-) A-I      intronic
chr17:28608745(-) A-I      intronic
chr17:28582832(-) A-I      intronic
chr17:28595792(-) A-I      intronic
chr17:28595833(-) A-I      intronic
chr17:28595872(-) A-I      intronic
chr17:28595892(-) A-I      intronic
chr17:28596363(-) A-I      intronic
chr17:28596406(-) A-I      intronic
chr17:28596412(-) A-I      intronic
chr17:28596426(-) A-I      intronic
chr17:28605852(-) A-I      intronic
chr17:28605856(-) A-I      intronic
chr17:28606744(-) A-I      intronic
chr17:28610096(-) A-I      intronic
chr17:28610172(-) A-I      intronic
chr17:28615738(-) A-I      intronic
chr17:28615739(-) A-I      intronic
chr17:28615963(-) A-I      intronic
chr17:28583021(-) A-I      intronic
chr17:28583552(-) A-I      intronic
chr17:28609165(-) A-I      intronic
chr17:28583101(-) A-I      intronic
chr17:28615482(-) A-I      intronic
chr17:28585124(-) A-I      intronic
chr17:28583178(-) A-I      intronic
chr17:28606768(-) A-I      intronic
chr17:28583526(-) A-I      intronic
chr17:28583194(-) A-I      intronic
chr17:28582815(-) A-I      intronic
chr17:28607633(-) A-I      intronic
chr17:28596301(-) A-I      intronic
chr17:28596014(-) A-I      intronic
chr17:28615536(-) A-I      intronic
chr17:28583069(-) A-I      intronic
chr17:28615413(-) A-I      intronic
chr17:28583527(-) A-I      intronic
chr17:28583200(-) A-I      intronic
chr17:28583124(-) A-I      intronic
chr17:28583132(-) A-I      intronic
chr17:28582710(-) A-I      intronic
chr17:28582829(-) A-I      intronic
chr17:28607659(-) A-I      intronic
chr17:28615638(-) A-I      intronic
chr17:28595975(-) A-I      intronic
chr17:28615928(-) A-I      intronic
chr17:28596307(-) A-I      intronic
chr17:28605755(-) A-I      intronic
chr17:28596011(-) A-I      intronic
chr17:28601875(-) A-I      intronic
chr17:28615414(-) A-I      intronic
chr17:28607587(-) A-I      intronic
chr17:28596284(-) A-I      intronic
chr17:28610678(-) A-I      intronic
chr17:28607592(-) A-I      intronic
chr17:28593431(-) A-I      intronic
chr17:28583068(-) A-I      intronic
chr17:28610174(-) A-I      intronic
chr17:28607605(-) A-I      intronic
chr17:28606814(-) A-I      intronic
chr17:28606811(-) A-I      intronic
chr17:28615954(-) A-I      intronic
chr17:28606751(-) A-I      intronic
chr17:28583043(-) A-I      intronic
chr17:28610128(-) A-I      intronic
chr17:28610153(-) A-I      intronic
chr17:28582748(-) A-I      intronic
chr17:28582735(-) A-I      intronic
chr17:28596292(-) A-I      intronic
chr17:28615443(-) A-I      intronic
chr17:28601991(-) A-I      intronic
chr17:28606763(-) A-I      intronic
chr17:28595889(-) A-I      intronic
chr17:28595976(-) A-I      intronic
chr17:28601733(-) A-I      intronic
chr17:28595639(-) A-I      intronic
chr17:28595863(-) A-I      intronic
chr17:28596343(-) A-I      intronic
chr17:28609948(-) A-I      intronic
chr17:28596478(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BLMH
chr17:28615638(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BLMH
chr17:28575316-28575317(-) m6A 3'UTR//exon       27773535
chr17:28575350-28575351(-) m6A 3'UTR//exon       27773535
chr17:28575395-28575396(-) m6A 3'UTR//exon       27773535
chr17:28575409-28575410(-) m6A 3'UTR//exon       27773535
chr17:28575462-28575463(-) m6A 3'UTR//exon       27773535
chr17:28575866-28575867(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828//22575960//22608085
chr17:28575896-28575897(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575926-28575927(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575944-28575945(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575968-28575969(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575980-28575981(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576000-28576001(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576059-28576060(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576082-28576083(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576128-28576129(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960//22608085
chr17:28576214-28576215(-) m6A exon//intron       24209618
chr17:28614870-28614871(-) m6A 3'UTR//CDS//intron       -
chr17:28614927-28614928(-) m6A 3'UTR//CDS//intron       -
chr17:28618445-28618446(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618488-28618489(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618677-28618678(-) m6A 5'UTR//intron       -
chr17:28618878-28618879(-) m6A 5'UTR//exon//intron       27773536
chr17:28619025-28619026(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-101-5p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
BLMH
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-101-5p
Benzothiazole 7222 Drug interaction    RC00006831
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-101-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-101-5p
Interactor2: BLMH

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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