Basic Information:

  VIRBase ID:  

HHID00008823

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          FAM76A:  NM_001143913     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	FAM76A
miRBase Accession/Entrez ID	MIMAT0004512	199870
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM76A	chr1:28078440(+) A-I      intronic chr1:28073016(+) A-I      intronic chr1:28073017(+) A-I      intronic chr1:28073022(+) A-I      intronic chr1:28073045(+) A-I      intronic chr1:28073046(+) A-I      intronic chr1:28073117(+) A-I      intronic chr1:28073118(+) A-I      intronic chr1:28086365(+) A-I      intronic chr1:28073123(+) A-I      intronic chr1:28076018(+) A-I      intronic chr1:28076020(+) A-I      intronic chr1:28078141(+) A-I      intronic chr1:28076026(+) A-I      intronic chr1:28076038(+) A-I      intronic chr1:28088325(+) A-I      3'UTR chr1:28088324(+) A-I      3'UTR chr1:28088302(+) A-I      3'UTR chr1:28088287(+) A-I      3'UTR chr1:28088277(+) A-I      3'UTR chr1:28076060(+) A-I      intronic chr1:28076066(+) A-I      intronic chr1:28077543(+) A-I      intronic chr1:28078142(+) A-I      intronic chr1:28078145(+) A-I      intronic chr1:28078157(+) A-I      intronic chr1:28078161(+) A-I      intronic chr1:28078165(+) A-I      intronic chr1:28086391(+) A-I      intronic chr1:28086378(+) A-I      intronic chr1:28086372(+) A-I      intronic chr1:28086418(+) A-I      intronic chr1:28063643(+) A-I      intronic chr1:28076042(+) A-I      intronic chr1:28063645(+) A-I      intronic chr1:28076057(+) A-I      intronic chr1:28066152(+) A-I      intronic chr1:28064731(+) A-I      intronic chr1:28063728(+) A-I      intronic chr1:28063590(+) A-I      intronic chr1:28063578(+) A-I      intronic chr1:28063564(+) A-I      intronic chr1:28062736(+) A-I      intronic chr1:28062704(+) A-I      intronic chr1:28082943(+) A-I      intronic chr1:28084448(+) A-I      intronic chr1:28077556(+) A-I      intronic chr1:28078389(+) A-I      intronic chr1:28077418(+) A-I      intronic chr1:28060101(+) A-I      intronic chr1:28058794(+) A-I      intronic chr1:28083983(+) A-I      intronic chr1:28058731(+) A-I      intronic chr1:28058669(+) A-I      intronic chr1:28058524(+) A-I      intronic chr1:28058432(+) A-I      intronic chr1:28055328(+) A-I      intronic chr1:28055324(+) A-I      intronic chr1:28079643(+) A-I      intronic chr1:28079648(+) A-I      intronic chr1:28079663(+) A-I      intronic chr1:28079671(+) A-I      intronic chr1:28079678(+) A-I      intronic chr1:28080711(+) A-I      intronic chr1:28080717(+) A-I      intronic chr1:28080721(+) A-I      intronic chr1:28080735(+) A-I      intronic chr1:28078379(+) A-I      intronic chr1:28062686(+) A-I      intronic chr1:28062584(+) A-I      intronic chr1:28062583(+) A-I      intronic chr1:28062578(+) A-I      intronic chr1:28062577(+) A-I      intronic chr1:28078378(+) A-I      intronic chr1:28077578(+) A-I      intronic chr1:28077572(+) A-I      intronic chr1:28080744(+) A-I      intronic chr1:28080747(+) A-I      intronic chr1:28080807(+) A-I      intronic chr1:28082211(+) A-I      intronic chr1:28082919(+) A-I      intronic chr1:28077402(+) A-I      intronic chr1:28076015(+) A-I      intronic chr1:28074763(+) A-I      intronic chr1:28074380(+) A-I      intronic chr1:28074372(+) A-I      intronic chr1:28073474(+) A-I      intronic chr1:28073339(+) A-I      intronic chr1:28073333(+) A-I      intronic chr1:28073188(+) A-I      intronic chr1:28072972(+) A-I      intronic chr1:28069762(+) A-I      intronic chr1:28069755(+) A-I      intronic chr1:28068315(+) A-I      intronic chr1:28067909(+) A-I      intronic chr1:28078545(+) A-I      intronic chr1:28067488(+) A-I      intronic chr1:28067483(+) A-I      intronic chr1:28066155(+) A-I      intronic chr1:28075002(+) A-I      intronic chr1:28084367(+) A-I      intronic chr1:28074351(+) A-I      intronic chr1:28074817(+) A-I      intronic chr1:28082968(+) A-I      intronic chr1:28064630(+) A-I      intronic chr1:28082982(+) A-I      intronic chr1:28060282(+) A-I      intronic chr1:28073505(+) A-I      intronic chr1:28084233(+) A-I      intronic chr1:28070233(+) A-I      intronic chr1:28088344(+) A-I      3'UTR chr1:28055052(+) A-I      intronic chr1:28073448(+) A-I      intronic chr1:28083447(+) A-I      intronic chr1:28088371(+) A-I      3'UTR chr1:28082250(+) A-I      intronic chr1:28084142(+) A-I      intronic chr1:28083459(+) A-I      intronic chr1:28082976(+) A-I      intronic chr1:28084476(+) A-I      intronic chr1:28082202(+) A-I      intronic chr1:28077593(+) A-I      intronic chr1:28083847(+) A-I      intronic chr1:28083471(+) A-I      intronic chr1:28082931(+) A-I      intronic chr1:28064937(+) A-I      intronic chr1:28084232(+) A-I      intronic chr1:28083339(+) A-I      intronic chr1:28083525(+) A-I      intronic chr1:28084494(+) A-I      intronic chr1:28082967(+) A-I      intronic chr1:28075174(+) A-I      intronic chr1:28083064(+) A-I      intronic chr1:28084060(+) A-I      intronic chr1:28083408(+) A-I      intronic chr1:28064615(+) A-I      intronic chr1:28083316(+) A-I      intronic chr1:28083804(+) A-I      intronic chr1:28075953(+) A-I      intronic chr1:28073402(+) A-I      intronic chr1:28083485(+) A-I      intronic chr1:28074352(+) A-I      intronic chr1:28083419(+) A-I      intronic chr1:28084154(+) A-I      intronic chr1:28083837(+) A-I      intronic chr1:28073163(+) A-I      intronic chr1:28083426(+) A-I      intronic chr1:28083784(+) A-I      intronic chr1:28063640(+) A-I      intronic chr1:28082928(+) A-I      intronic chr1:28066227(+) A-I      intronic chr1:28056993(+) A-I      intronic chr1:28059714(+) A-I      intronic chr1:28082230(+) A-I      intronic chr1:28070201(+) A-I      intronic chr1:28063665(+) A-I      intronic chr1:28084394(+) A-I      intronic chr1:28084053(+) A-I      intronic chr1:28074280(+) A-I      intronic chr1:28070436(+) A-I      intronic chr1:28082882(+) A-I      intronic chr1:28077609(+) A-I      intronic chr1:28083412(+) A-I      intronic chr1:28083423(+) A-I      intronic chr1:28083490(+) A-I      intronic chr1:28082363(+) A-I      intronic chr1:28064466(+) A-I      intronic chr1:28083942(+) A-I      intronic chr1:28085099(+) A-I      intronic chr1:28078520(+) A-I      intronic chr1:28073332(+) A-I      intronic chr1:28083554(+) A-I      intronic chr1:28075929(+) A-I      intronic chr1:28083773(+) A-I      intronic chr1:28084408(+) A-I      intronic chr1:28074809(+) A-I      intronic chr1:28074310(+) A-I      intronic chr1:28082108(+) A-I      intronic chr1:28084077(+) A-I      intronic chr1:28073491(+) A-I      intronic chr1:28083865(+) A-I      intronic chr1:28082902(+) A-I      intronic chr1:28062655(+) A-I      intronic chr1:28083527(+) A-I      intronic chr1:28058433(+) A-I      intronic chr1:28063509(+) A-I      intronic chr1:28074842(+) A-I      intronic chr1:28058818(+) A-I      intronic chr1:28084008(+) A-I      intronic chr1:28067480(+) A-I      intronic chr1:28064651(+) A-I      intronic chr1:28083472(+) A-I      intronic chr1:28083036(+) A-I      intronic chr1:28054448(+) A-I      intronic chr1:28066178(+) A-I      intronic chr1:28062815(+) A-I      intronic chr1:28058790(+) A-I      intronic chr1:28073182(+) A-I      intronic chr1:28070688(+) A-I      intronic chr1:28083315(+) A-I      intronic chr1:28070129(+) A-I      intronic chr1:28083979(+) A-I      intronic chr1:28084433(+) A-I      intronic chr1:28083322(+) A-I      intronic chr1:28085139(+) A-I      intronic chr1:28084080(+) A-I      intronic chr1:28082188(+) A-I      intronic chr1:28083369(+) A-I      intronic chr1:28077639(+) A-I      intronic chr1:28075132(+) A-I      intronic chr1:28083321(+) A-I      intronic chr1:28084024(+) A-I      intronic chr1:28083076(+) A-I      intronic chr1:28062722(+) A-I      intronic chr1:28077542(+) A-I      intronic chr1:28083803(+) A-I      intronic chr1:28073095(+) A-I      intronic chr1:28083063(+) A-I      intronic chr1:28075958(+) A-I      intronic chr1:28084377(+) A-I      intronic chr1:28088355(+) A-I      3'UTR chr1:28063703(+) A-I      intronic chr1:28079596(+) A-I      intronic chr1:28083418(+) A-I      intronic chr1:28078218(+) A-I      intronic chr1:28063538(+) A-I      intronic chr1:28083849(+) A-I      intronic chr1:28085230(+) A-I      intronic chr1:28058788(+) A-I      intronic chr1:28078339(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM76A	chr1:28055389(+) T-C intron -    22484847 chr1:28055400(+) A-T intron -    22484847 chr1:28058433(+) A-G intron -    22484847 chr1:28058788(+) A-G intron -    22484847 chr1:28058790(+) A-G intron -    22484847 chr1:28058818(+) A-G intron -    22484847 chr1:28062655(+) A-G intron -    22484847 chr1:28063640(+) A-G intron -    22484847 chr1:28063703(+) A-G intron -    22484847 chr1:28082108(+) A-G intron -    22484847 chr1:28082902(+) A-G intron -    22484847 chr1:28083063(+) A-G intron -    22484847 chr1:28083322(+) A-G intron -    22484847 chr1:28083418(+) A-G intron -    22484847 chr1:28083525(+) A-G intron -    22484847 chr1:28083527(+) A-G intron -    22484847 chr1:28083979(+) A-G intron -    22484847 chr1:28084008(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM76A	chr1:28065837-28065838(+) m6A intron       22608085 chr1:28065878-28065879(+) m6A intron       22608085 chr1:28065889-28065890(+) m6A intron       22608085 chr1:28086094-28086095(+) m6A CDS       24981863 chr1:28086108-28086109(+) m6A CDS       24981863 chr1:28086128-28086129(+) m6A CDS       24981863 chr1:28087247-28087248(+) m6A 3'UTR       27773535 chr1:28087270-28087271(+) m6A 3'UTR       27773535 chr1:28087326-28087327(+) m6A 3'UTR       27773535 chr1:28087820-28087821(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	FAM76A	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: FAM76A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).