Basic Information:

  VIRBase ID:  

HHID00008787

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          LSM14B:  NM_144703     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	LSM14B
miRBase Accession/Entrez ID	MIMAT0004512	149986
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bA11M20.3//C20orf40//FAM61B//FT005//LSM13//RAP55B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LSM14B	chr20:60700956(+) A-I      intronic chr20:60700036(+) A-I      intronic chr20:60700963(+) A-I      intronic chr20:60700960(+) A-I      intronic chr20:60700066(+) A-I      intronic chr20:60700006(+) A-I      intronic chr20:60700120(+) A-I      intronic chr20:60700137(+) A-I      intronic chr20:60700073(+) A-I      intronic chr20:60700112(+) A-I      intronic chr20:60700134(+) A-I      intronic chr20:60701058(+) A-I      intronic chr20:60700146(+) A-I      intronic chr20:60700157(+) A-I      intronic chr20:60700901(+) A-I      intronic chr20:60700906(+) A-I      intronic chr20:60700914(+) A-I      intronic chr20:60700957(+) A-I      intronic chr20:60700964(+) A-I      intronic chr20:60700965(+) A-I      intronic chr20:60700966(+) A-I      intronic chr20:60700196(+) A-I      intronic chr20:60700001(+) A-I      intronic chr20:60700995(+) A-I      intronic chr20:60700915(+) A-I      intronic chr20:60700951(+) A-I      intronic chr20:60700996(+) A-I      intronic chr20:60700940(+) A-I      intronic chr20:60701813(+) A-I      intronic chr20:60700076(+) A-I      intronic chr20:60701891(+) A-I      intronic chr20:60700037(+) A-I      intronic chr20:60701005(+) A-I      intronic chr20:60700939(+) A-I      intronic chr20:60700017(+) A-I      intronic chr20:60700954(+) A-I      intronic chr20:60700955(+) A-I      intronic chr20:60700861(+) A-I      intronic chr20:60700203(+) A-I      intronic chr20:60701998(+) A-I      intronic chr20:60700969(+) A-I      intronic chr20:60700111(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LSM14B	chr20:60700995(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LSM14B	chr20:60699787-60699788(+) m6A 5'UTR//CDS       - chr20:60701285-60701286(+) m6A CDS//intron       - chr20:60705325-60705326(+) m6A CDS//intron       22575960 chr20:60705332-60705333(+) m6A CDS//intron       22575960 chr20:60705588-60705589(+) m6A CDS       22575960 chr20:60705596-60705597(+) m6A CDS       22575960 chr20:60705621-60705622(+) m6A CDS       22575960 chr20:60705645-60705646(+) m6A CDS       24981863//27773535 chr20:60705733-60705734(+) m6A CDS       27773535 chr20:60706550-60706551(+) m6A CDS       24284625//24209618 chr20:60706557-60706558(+) m6A CDS       24284625//24209618 chr20:60708368-60708369(+) Am CDS       - chr20:60708391-60708392(+) m6A CDS       24284625//24209618 chr20:60708466-60708467(+) m6A CDS       24284625//24209618 chr20:60708502-60708503(+) m6A CDS       24284625//24209618 chr20:60709324-60709325(+) m6A 3'UTR       24284625//24209618//24981863 chr20:60709349-60709350(+) m6A 3'UTR       24284625//24209618//24981863 chr20:60709359-60709360(+) m6A 3'UTR       24284625//24209618//24981863 chr20:60709365-60709366(+) m6A 3'UTR       24284625//24209618//24981863 chr20:60709382-60709383(+) m6A 3'UTR       24284625//24209618//24981863 chr20:60709774-60709775(+) m6A 3'UTR       - chr20:60709779-60709780(+) m6A 3'UTR       - chr20:60709836-60709837(+) m6A 3'UTR       - chr20:60710016-60710017(+) m6A 3'UTR       24284625 chr20:60710053-60710054(+) m6A 3'UTR       24284625 chr20:60710262-60710263(+) m6A 3'UTR       24209618 chr20:60710338-60710339(+) m6A 3'UTR       24209618//27773535 chr20:60710359-60710360(+) m6A 3'UTR       24209618//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LSM14B	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: LSM14B

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).