Basic Information:

  VIRBase ID:  

HHID00008777

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          ASB11:  NM_001012428     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	ASB11
miRBase Accession/Entrez ID	MIMAT0004512	140456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ASB11	chrX:15299311(-) A-I      intronic chrX:15299242(-) A-I      intronic chrX:15299235(-) A-I      intronic chrX:15299151(-) A-I      intronic chrX:15299125(-) A-I      intronic chrX:15299948(-) A-I      3'UTR chrX:15299968(-) A-I      3'UTR chrX:15300035(-) A-I      3'UTR chrX:15299888(-) A-I      3'UTR chrX:15299997(-) A-I      3'UTR chrX:15299916(-) A-I      3'UTR chrX:15299922(-) A-I      3'UTR chrX:15299893(-) A-I      3'UTR chrX:15299206(-) A-I      intronic chrX:15314295(-) A-I      intronic chrX:15299548(-) A-I      intronic chrX:15314373(-) A-I      intronic chrX:15303400(-) A-I      intronic chrX:15299980(-) A-I      3'UTR chrX:15299998(-) A-I      3'UTR chrX:15299984(-) A-I      3'UTR chrX:15299993(-) A-I      3'UTR chrX:15314319(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ASB11	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: ASB11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).