Basic Information:

  VIRBase ID:  

HHID00008774

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          CIBAR1:  NR_104267     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	CIBAR1
miRBase Accession/Entrez ID	MIMAT0004512	137392
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BARMR1//FAM92A//FAM92A1//PAPA9

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CIBAR1	chr8:94732984(+) A-I      intronic chr8:94722257(+) A-I      intronic chr8:94734847(+) A-I      intronic chr8:94734839(+) A-I      intronic chr8:94732448(+) A-I      intronic chr8:94722362(+) A-I      intronic chr8:94732433(+) A-I      intronic chr8:94732432(+) A-I      intronic chr8:94722351(+) A-I      intronic chr8:94734855(+) A-I      intronic chr8:94722342(+) A-I      intronic chr8:94732421(+) A-I      intronic chr8:94732472(+) A-I      intronic chr8:94722293(+) A-I      intronic chr8:94734783(+) A-I      intronic chr8:94734806(+) A-I      intronic chr8:94732988(+) A-I      intronic chr8:94722258(+) A-I      intronic chr8:94732978(+) A-I      intronic chr8:94732493(+) A-I      intronic chr8:94736183(+) A-I      intronic chr8:94735342(+) A-I      intronic chr8:94722828(+) A-I      intronic chr8:94726986(+) A-I      intronic chr8:94736205(+) A-I      intronic chr8:94734671(+) A-I      intronic chr8:94736682(+) A-I      intronic chr8:94734672(+) A-I      intronic chr8:94722279(+) A-I      intronic chr8:94731297(+) A-I      intronic chr8:94731123(+) A-I      intronic chr8:94736274(+) A-I      intronic chr8:94737479(+) A-I      intronic chr8:94726951(+) A-I      intronic chr8:94735364(+) A-I      intronic chr8:94731150(+) A-I      intronic chr8:94732995(+) A-I      intronic chr8:94731327(+) A-I      intronic chr8:94736231(+) A-I      intronic chr8:94734805(+) A-I      intronic chr8:94736408(+) A-I      intronic chr8:94736736(+) A-I      intronic chr8:94722398(+) A-I      intronic chr8:94732484(+) A-I      intronic chr8:94725150(+) A-I      intronic chr8:94726994(+) A-I      intronic chr8:94722824(+) A-I      intronic chr8:94736400(+) A-I      intronic chr8:94725522(+) A-I      intronic chr8:94718161(+) A-I      intronic chr8:94722790(+) A-I      intronic chr8:94736278(+) A-I      intronic chr8:94722411(+) A-I      intronic chr8:94722915(+) A-I      intronic chr8:94736426(+) A-I      intronic chr8:94736250(+) A-I      intronic chr8:94732844(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CIBAR1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: CIBAR1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).