Basic Information:

  VIRBase ID:  

HHID00008762

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          TRABD2A:  NM_001277053     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	TRABD2A
miRBase Accession/Entrez ID	MIMAT0004512	129293
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C2orf89//TIKI1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRABD2A	chr2:85090838(-) A-I      intronic chr2:85105567(-) A-I      intronic chr2:85105566(-) A-I      intronic chr2:85090860(-) A-I      intronic chr2:85090841(-) A-I      intronic chr2:85059680(-) A-I      ncRNA chr2:85085116(-) A-I      intronic chr2:85080959(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRABD2A	chr2:85048935-85048936(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960 chr2:85049002-85049003(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960 chr2:85049016-85049017(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960 chr2:85049054-85049055(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85049060-85049061(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85049096-85049097(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85049169-85049170(-) m6A CDS//exon       24284625 chr2:85049188-85049189(-) m6A CDS//exon       24284625 chr2:85059207-85059208(-) m6A CDS//exon       24284625 chr2:85061805-85061806(-) m6A exon//intron       24284625 chr2:85061814-85061815(-) m6A exon//intron       24284625 chr2:85063454-85063455(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960 chr2:85063465-85063466(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960 chr2:85063491-85063492(-) m6A exon//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr2:85063562-85063563(-) m6A exon//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr2:85063596-85063597(-) m6A exon//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr2:85063613-85063614(-) m6A exon//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr2:85063666-85063667(-) m6A exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr2:85063772-85063773(-) m6A exon//intron       24284625//24981863//27773535 chr2:85063817-85063818(-) m6A exon//intron       24284625//24981863//27773535 chr2:85063932-85063933(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr2:85063945-85063946(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr2:85063976-85063977(-) m6A exon//intron       24284625//24981863//27773535//22608085 chr2:85064010-85064011(-) m6A exon//intron       24284625//24981863//27773535 chr2:85064065-85064066(-) m6A exon//intron       24284625//27773535 chr2:85064143-85064144(-) m6A exon//intron       24284625 chr2:85064212-85064213(-) m6A exon//intron       24284625 chr2:85064222-85064223(-) m6A exon//intron       24284625 chr2:85064425-85064426(-) m6A exon//intron       24981863 chr2:85064475-85064476(-) m6A exon//intron       24284625//24981863 chr2:85064520-85064521(-) m6A exon//intron       24284625//24981863 chr2:85064551-85064552(-) m6A exon//intron       24284625//24981863 chr2:85064563-85064564(-) m6A exon//intron       24284625//24981863 chr2:85064574-85064575(-) m6A exon//intron       24284625//24981863 chr2:85064638-85064639(-) m6A exon//intron       24284625//24981863//22575960 chr2:85064661-85064662(-) m6A exon//intron       24284625//24981863//22575960 chr2:85064688-85064689(-) m6A exon//intron       24284625//24981863//22575960 chr2:85064697-85064698(-) m6A exon//intron       24284625//24981863//22575960 chr2:85064744-85064745(-) m6A exon//intron       24284625//22575960 chr2:85064795-85064796(-) m6A exon//intron       24284625 chr2:85064826-85064827(-) m6A exon//intron       24284625 chr2:85064944-85064945(-) m6A 3'UTR//exon//intron       24284625 chr2:85065040-85065041(-) m6A 3'UTR//exon//intron       24284625//24981863 chr2:85065120-85065121(-) m6A 3'UTR//exon//intron       24284625//24981863 chr2:85065285-85065286(-) m6A 3'UTR//exon//intron       24284625 chr2:85065313-85065314(-) m6A 3'UTR//exon//intron       24284625 chr2:85065331-85065332(-) m6A 3'UTR//exon//intron       24284625 chr2:85069021-85069022(-) m6A CDS//exon//intron       24284625 chr2:85069038-85069039(-) m6A CDS//exon//intron       24284625 chr2:85069109-85069110(-) m6A CDS//exon//intron       24284625 chr2:85069114-85069115(-) m6A CDS//exon//intron       24284625 chr2:85070712-85070713(-) m6A exon//intron       24284625 chr2:85070738-85070739(-) m6A exon//intron       24284625 chr2:85097358-85097359(-) m6A CDS       24284625//25456834//24981863//27371828//22575960 chr2:85097395-85097396(-) Am CDS       - chr2:85097414-85097415(-) m6A CDS       24284625//25456834//24981863//27371828//22575960 chr2:85097451-85097452(-) m6A CDS       24284625//25456834//24981863//27371828//22575960 chr2:85097481-85097482(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85097541-85097542(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85097568-85097569(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960 chr2:85097595-85097596(-) m6A CDS//exon       24284625//25456834//24981863//27371828//22575960//22608085 chr2:85097664-85097665(-) m6A CDS//exon       24284625//24981863//27371828//22575960//22608085 chr2:85097688-85097689(-) m6A CDS//exon       24284625//24981863//27371828//22575960//22608085 chr2:85097742-85097743(-) m6A CDS//exon       24284625//24981863//22575960//22608085 chr2:85097814-85097815(-) m6A CDS//exon       24284625//24981863//22575960 chr2:85097868-85097869(-) m6A CDS//exon       24284625//24981863//22575960 chr2:85097881-85097882(-) m6A CDS//exon       24284625//24981863//22575960 chr2:85108132-85108133(-) m6A CDS//intron       24284625//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	TRABD2A	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: TRABD2A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).