Basic Information:

  VIRBase ID:  

HHID00008745

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          ZFYVE27:  NM_001174122     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	ZFYVE27
miRBase Accession/Entrez ID	MIMAT0004512	118813
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PROTRUDIN//SPG33

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE27	chr10:99498880(+) A-I      intronic chr10:99514170(+) A-I      intronic chr10:99501836(+) A-I      intronic chr10:99501663(+) A-I      intronic chr10:99501769(+) A-I      intronic chr10:99501706(+) A-I      intronic chr10:99498905(+) A-I      intronic chr10:99501833(+) A-I      intronic chr10:99501869(+) A-I      intronic chr10:99501837(+) A-I      intronic chr10:99501770(+) A-I      intronic chr10:99498933(+) A-I      intronic chr10:99499061(+) A-I      intronic chr10:99499100(+) A-I      intronic chr10:99501807(+) A-I      intronic chr10:99501619(+) A-I      intronic chr10:99519736(+) A-I      3'UTR chr10:99514144(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE27	chr10:99496941-99496942(+) m6A 5'UTR//exon       24981863 chr10:99496956-99496957(+) m6A 5'UTR//exon       24981863 chr10:99510126-99510127(+) m6A CDS//exon       - chr10:99510198-99510199(+) m6A CDS//exon       - chr10:99511148-99511149(+) m6A CDS//exon       24209618//24981863 chr10:99512616-99512617(+) m6A CDS//intron       24209618//24981863 chr10:99512846-99512847(+) m6A CDS       24209618//24981863 chr10:99519320-99519321(+) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085 chr10:99519333-99519334(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr10:99519376-99519377(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr10:99519440-99519441(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr10:99519616-99519617(+) m6A 3'UTR       24284625//24981863 chr10:99519635-99519636(+) m6A 3'UTR       24284625//24981863 chr10:99519743-99519744(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr10:99519767-99519768(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr10:99519783-99519784(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr10:99520299-99520300(+) m6A 3'UTR       - chr10:99520329-99520330(+) m6A 3'UTR       - chr10:99520336-99520337(+) m6A 3'UTR       - chr10:99520409-99520410(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZFYVE27	Chromatin K562 cells     - Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: ZFYVE27

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).