Detail Information

Basic Information:


  VIRBase ID:  

HHID00008715

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           YTHDC1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p YTHDC1
miRBase
Accession/Entrez ID		 MIMAT0004512 91746
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - YT521//YT521-B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR YTHDC1
chr4:69210717(-) A-I      intronic
chr4:69210743(-) A-I      intronic
chr4:69192503(-) A-I      intronic
chr4:69192871(-) A-I      intronic
chr4:69210494(-) A-I      intronic
chr4:69210497(-) A-I      intronic
chr4:69210699(-) A-I      intronic
chr4:69210708(-) A-I      intronic
chr4:69210716(-) A-I      intronic
chr4:69192842(-) A-I      intronic
chr4:69182873(-) A-I      intronic
chr4:69192894(-) A-I      intronic
chr4:69192789(-) A-I      intronic
chr4:69192477(-) A-I      intronic
chr4:69184093(-) A-I      intronic
chr4:69182942(-) A-I      intronic
chr4:69182685(-) A-I      intronic
chr4:69192792(-) A-I      intronic
chr4:69182818(-) A-I      intronic
chr4:69182814(-) A-I      intronic
chr4:69182705(-) A-I      intronic
chr4:69182694(-) A-I      intronic
chr4:69182928(-) A-I      intronic
chr4:69192953(-) A-I      intronic
chr4:69192414(-) A-I      intronic
chr4:69192951(-) A-I      intronic
chr4:69184058(-) A-I      intronic
chr4:69210588(-) A-I      intronic
chr4:69192437(-) A-I      intronic
chr4:69209393(-) A-I      intronic
chr4:69182732(-) A-I      intronic
chr4:69192832(-) A-I      intronic
chr4:69182756(-) A-I      intronic
chr4:69209488(-) A-I      intronic
chr4:69211968(-) A-I      intronic
chr4:69192897(-) A-I      intronic
chr4:69183931(-) A-I      intronic
chr4:69192512(-) A-I      intronic
chr4:69182936(-) A-I      intronic
chr4:69182728(-) A-I      intronic
chr4:69192382(-) A-I      intronic
chr4:69209045(-) A-I      intronic
chr4:69182761(-) A-I      intronic
chr4:69192581(-) A-I      intronic
chr4:69210654(-) A-I      intronic
chr4:69184029(-) A-I      intronic
chr4:69192401(-) A-I      intronic
chr4:69192385(-) A-I      intronic
chr4:69191300(-) A-I      intronic
chr4:69183945(-) A-I      intronic
chr4:69192447(-) A-I      intronic
chr4:69192469(-) A-I      intronic
chr4:69184053(-) A-I      intronic
chr4:69192536(-) A-I      intronic
chr4:69192406(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED YTHDC1
chr4:69201789(-) A-I intron -    15258596
chr4:69201790(-) A-I intron -    15258596
chr4:69201794(-) A-I intron -    15258596

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase YTHDC1
chr4:69178691-69178692(-) m6A 3'UTR       27773535
chr4:69179576-69179577(-) m6A 3'UTR       24981863//26404942//22608085
chr4:69179640-69179641(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr4:69179649-69179650(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr4:69179847-69179848(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69179853-69179854(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69179913-69179914(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69179937-69179938(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69179955-69179956(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69179969-69179970(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr4:69181998-69181999(-) m6A CDS//intron       24981863
chr4:69182076-69182077(-) m6A CDS       24981863//26404942//27773535
chr4:69182145-69182146(-) m6A CDS       24981863//26404942//27773535
chr4:69184260-69184261(-) m6A CDS       24981863//27773535
chr4:69184546-69184547(-) m6A CDS       27773535
chr4:69185844-69185845(-) m6A CDS       24981863//27773535
chr4:69185880-69185881(-) m6A CDS       24209618//24981863//27773535
chr4:69188338-69188339(-) m6A exon//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr4:69188447-69188448(-) m6A exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr4:69188486-69188487(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr4:69188611-69188612(-) m6A CDS//exon       27773535
chr4:69188624-69188625(-) m6A CDS//exon       27773535
chr4:69189859-69189860(-) m6A CDS//exon       27773535
chr4:69189876-69189877(-) Am CDS//exon       -
chr4:69189883-69189884(-) m6A CDS//exon       27773535
chr4:69189889-69189890(-) m6A CDS//exon       27773535
chr4:69197909-69197910(-) m6A CDS       27773535
chr4:69202860-69202861(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr4:69202874-69202875(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr4:69202887-69202888(-) m1A CDS       26863196
chr4:69202965-69202966(-) m1A CDS       26863196
chr4:69202977-69202978(-) m1A CDS       26863196
chr4:69202986-69202987(-) m1A CDS       26863196
chr4:69203007-69203008(-) m1A CDS       26863196
chr4:69203040-69203041(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr4:69203074-69203075(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr4:69203103-69203104(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr4:69203109-69203110(-) m1A CDS       26863196
chr4:69203351-69203352(-) m6A CDS       24981863//26404942//27773535//22608085
chr4:69203376-69203377(-) m6A CDS       24981863//27773535
chr4:69203431-69203432(-) m6A CDS       24981863//27773535
chr4:69203547-69203548(-) m6A CDS       24981863//27773535
chr4:69204022-69204023(-) m6A 5'UTR//CDS       24209618//24981863//27773535
chr4:69204043-69204044(-) m6A 5'UTR//CDS       24209618//24981863//27773535
chr4:69204055-69204056(-) m6A 5'UTR//CDS       24209618//24981863//27773535
chr4:69204094-69204095(-) m6A 5'UTR//CDS       24209618//24981863//27773535//27371828//27773536
chr4:69209789-69209790(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828//27773536
chr4:69209794-69209795(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828//27773536
chr4:69215484-69215485(-) m6A 5'UTR       24209618//24981863//27371828//27773536
chr4:69215570-69215571(-) m6A 5'UTR       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
YTHDC1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: YTHDC1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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