Basic Information:

  VIRBase ID:  

HHID00008650

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          PPP1R14C:  NM_030949     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	PPP1R14C
miRBase Accession/Entrez ID	MIMAT0004512	81706
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPI17-like//KEPI//NY-BR-81

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPP1R14C	chr6:150505627(+) A-I      intronic chr6:150556377(+) A-I      intronic chr6:150556382(+) A-I      intronic chr6:150505622(+) A-I      intronic chr6:150495982(+) A-I      intronic chr6:150555808(+) A-I      intronic chr6:150481645(+) A-I      intronic chr6:150555799(+) A-I      intronic chr6:150504773(+) A-I      intronic chr6:150556354(+) A-I      intronic chr6:150539418(+) A-I      intronic chr6:150539428(+) A-I      intronic chr6:150540062(+) A-I      intronic chr6:150502440(+) A-I      intronic chr6:150483291(+) A-I      intronic chr6:150488325(+) A-I      intronic chr6:150539997(+) A-I      intronic chr6:150543149(+) A-I      intronic chr6:150541157(+) A-I      intronic chr6:150528049(+) A-I      intronic chr6:150556509(+) A-I      intronic chr6:150556478(+) A-I      intronic chr6:150558379(+) A-I      intronic chr6:150562790(+) A-I      intronic chr6:150540058(+) A-I      intronic chr6:150539961(+) A-I      intronic chr6:150562767(+) A-I      intronic chr6:150539897(+) A-I      intronic chr6:150555752(+) A-I      intronic chr6:150539915(+) A-I      intronic chr6:150556428(+) A-I      intronic chr6:150539207(+) A-I      intronic chr6:150470555(+) A-I      intronic chr6:150564494(+) A-I      intronic chr6:150564523(+) A-I      intronic chr6:150539824(+) A-I      intronic chr6:150540040(+) A-I      intronic chr6:150469977(+) A-I      intronic chr6:150470147(+) A-I      intronic chr6:150555838(+) A-I      intronic chr6:150564588(+) A-I      intronic chr6:150564511(+) A-I      intronic chr6:150540050(+) A-I      intronic chr6:150539971(+) A-I      intronic chr6:150555770(+) A-I      intronic chr6:150470510(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPP1R14C	chr6:150464326-150464327(+) m6A 5'UTR       24209618 chr6:150464464-150464465(+) m6A CDS       24209618 chr6:150535931-150535932(+) m6A CDS       24209618 chr6:150537972-150537973(+) m6A CDS       24209618//24981863 chr6:150537982-150537983(+) m6A CDS       24209618//24981863 chr6:150569925-150569926(+) m6A CDS       24209618//24981863//22608085 chr6:150569963-150569964(+) m6A 3'UTR       24209618//24981863//22608085 chr6:150569973-150569974(+) m6A 3'UTR       24209618//24981863//22608085 chr6:150570021-150570022(+) m6A 3'UTR       24209618//24981863//22608085 chr6:150570051-150570052(+) m6A 3'UTR       24209618//24981863//22608085 chr6:150570109-150570110(+) m6A 3'UTR       24209618//24981863//22608085 chr6:150570227-150570228(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr6:150570269-150570270(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PPP1R14C	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: PPP1R14C

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).