Detail Information

Basic Information:


  VIRBase ID:  

HHID00008643

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:           SLC38A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-100-3p SLC38A1
miRBase
Accession/Entrez ID		 MIMAT0004512 81539
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATA1//NAT2//SAT1//SNAT1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-100-3p
rs1388368183 chr11:122152253    A/G
rs530428149 chr11:122152245    C/T
rs749039221 chr11:122152247    A/G
rs775253529 chr11:122152245    CTA/C
rs909526986 chr11:122152248    T/C
rs1321972926 chr11:122152258    C/T
rs770590792 chr11:122152255    A/G
rs773933142 chr11:122152260    T/C
rs773933142 chr11:122152260    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SLC38A1
chr12:46593218(-) A-I      intronic
chr12:46593244(-) A-I      intronic
chr12:46593369(-) A-I      intronic
chr12:46595863(-) A-I      intronic
chr12:46595907(-) A-I      intronic
chr12:46593393(-) A-I      intronic
chr12:46593201(-) A-I      intronic
chr12:46610586(-) A-I      intronic
chr12:46609428(-) A-I      intronic
chr12:46609329(-) A-I      intronic
chr12:46610557(-) A-I      intronic
chr12:46610417(-) A-I      intronic
chr12:46610413(-) A-I      intronic
chr12:46609284(-) A-I      intronic
chr12:46636583(-) A-I      intronic
chr12:46636579(-) A-I      intronic
chr12:46610412(-) A-I      intronic
chr12:46636502(-) A-I      intronic
chr12:46636490(-) A-I      intronic
chr12:46636476(-) A-I      intronic
chr12:46636473(-) A-I      intronic
chr12:46636463(-) A-I      intronic
chr12:46636461(-) A-I      intronic
chr12:46633246(-) A-I      intronic
chr12:46620622(-) A-I      intronic
chr12:46609339(-) A-I      intronic
chr12:46634118(-) A-I      intronic
chr12:46609303(-) A-I      intronic
chr12:46636337(-) A-I      intronic
chr12:46609355(-) A-I      intronic
chr12:46609359(-) A-I      intronic
chr12:46610591(-) A-I      intronic
chr12:46652601(-) A-I      intronic
chr12:46636379(-) A-I      intronic
chr12:46595880(-) A-I      intronic
chr12:46652491(-) A-I      intronic
chr12:46633219(-) A-I      intronic
chr12:46628234(-) A-I      intronic
chr12:46595923(-) A-I      intronic
chr12:46649837(-) A-I      intronic
chr12:46652636(-) A-I      intronic
chr12:46633349(-) A-I      intronic
chr12:46593257(-) A-I      intronic
chr12:46620537(-) A-I      intronic
chr12:46652669(-) A-I      intronic
chr12:46609297(-) A-I      intronic
chr12:46620536(-) A-I      intronic
chr12:46598861(-) A-I      intronic
chr12:46595906(-) A-I      intronic
chr12:46649757(-) A-I      intronic
chr12:46610629(-) A-I      intronic
chr12:46655059(-) A-I      intronic
chr12:46610561(-) A-I      intronic
chr12:46578378(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SLC38A1
chr12:46655059(-) A-I intron -    22327324
chr12:46610532(-) T-C intron -    22484847
chr12:46655059(-) A-G intron -    22484847
chr12:46609297(-) A-G intron -    22484847
chr12:46609303(-) A-G intron -    22484847
chr12:46609339(-) A-G intron -    22484847
chr12:46609355(-) A-G intron -    22484847
chr12:46609359(-) A-G intron -    22484847
chr12:46610561(-) A-G intron -    22484847
chr12:46610591(-) A-G intron -    22484847
chr12:46610629(-) A-G intron -    22484847
chr12:46610642(-) G-T intron -    22484847
chr12:46620536(-) A-G intron -    22484847
chr12:46620537(-) A-G intron -    22484847
chr12:46620579(-) G-A intron -    22484847
chr12:46620589(-) C-T intron -    22484847
chr12:46633349(-) A-G intron -    22484847
chr12:46634118(-) A-G intron -    22484847
chr12:46652491(-) A-G intron -    22484847
chr12:46652601(-) A-G intron -    22484847
chr12:46652636(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLC38A1
chr12:46576854-46576855(-) m6A 3'UTR       27773535
chr12:46576870-46576871(-) m6A 3'UTR       27773535
chr12:46576956-46576957(-) m6A 3'UTR       27773535
chr12:46576985-46576986(-) m6A 3'UTR       27773535
chr12:46577037-46577038(-) m6A 3'UTR       27773535
chr12:46577089-46577090(-) m6A 3'UTR       27773535
chr12:46577147-46577148(-) m6A 3'UTR       24284625//27773535
chr12:46577173-46577174(-) m6A 3'UTR       24284625//27773535
chr12:46577242-46577243(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr12:46577249-46577250(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr12:46577290-46577291(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr12:46577321-46577322(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr12:46577376-46577377(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr12:46577459-46577460(-) m6A 3'UTR       26404942
chr12:46577482-46577483(-) m6A 3'UTR       26404942
chr12:46577988-46577989(-) m6A 3'UTR       26404942
chr12:46578076-46578077(-) m6A 3'UTR       26404942
chr12:46578147-46578148(-) m6A 3'UTR       26404942
chr12:46578162-46578163(-) m6A 3'UTR       26404942
chr12:46578181-46578182(-) m6A 3'UTR       26404942
chr12:46578220-46578221(-) m6A 3'UTR       26404942
chr12:46578355-46578356(-) m6A 3'UTR       -
chr12:46579499-46579500(-) Y 3'UTR       26075521
chr12:46579633-46579634(-) m6A 3'UTR       22575960
chr12:46579659-46579660(-) m6A 3'UTR       26404942//22575960
chr12:46579684-46579685(-) m6A 3'UTR       26404942//22575960
chr12:46579716-46579717(-) m6A 3'UTR       26404942//22575960
chr12:46582430-46582431(-) m6A 3'UTR       26404942
chr12:46582439-46582440(-) m6A 3'UTR       26404942
chr12:46582599-46582600(-) m6A 3'UTR       24981863//26404942//27773535
chr12:46582605-46582606(-) m6A 3'UTR       24981863//26404942//27773535
chr12:46582653-46582654(-) m6A 3'UTR       24981863//26404942//27773535
chr12:46582732-46582733(-) m6A 3'UTR       27773535//22575960
chr12:46582750-46582751(-) m6A 3'UTR       27773535//22575960
chr12:46582770-46582771(-) Tm CDS       -
chr12:46589634-46589635(-) m6A 3'UTR//intron       24284625//25456834//22608085
chr12:46589747-46589748(-) m6A 3'UTR//intron       24284625//25456834//22608085
chr12:46589756-46589757(-) m6A 3'UTR//intron       24284625//25456834//22608085
chr12:46589847-46589848(-) m6A 3'UTR//intron       24284625
chr12:46591516-46591517(-) m6A CDS//exon       27773535
chr12:46591536-46591537(-) m6A CDS//exon       27773535
chr12:46623380-46623381(-) m6A CDS//exon       22575960
chr12:46633539-46633540(-) m6A CDS//intron       25456834//24981863//26404942//22575960//22608085
chr12:46633562-46633563(-) m6A CDS//intron       24981863//26404942//22575960//22608085
chr12:46633595-46633596(-) m6A 5'UTR//intron       24981863//26404942//22575960//22608085
chr12:46633602-46633603(-) m6A 5'UTR//intron       24981863//26404942//22575960//22608085
chr12:46633614-46633615(-) m6A 5'UTR//intron       24981863//26404942//22575960//22608085
chr12:46633629-46633630(-) m6A 5'UTR//intron       24981863//26404942//22575960//22608085
chr12:46637082-46637083(-) Y 5'UTR//intron       25219674
chr12:46653584-46653585(-) Am intron       -
chr12:46662352-46662353(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//27371828//22575960
chr12:46662367-46662368(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//27371828//22575960
chr12:46662383-46662384(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//27371828//27773536//22575960
chr12:46662390-46662391(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//27371828//27773536//22575960
chr12:46662405-46662406(-) m6A 5'UTR//exon//intron       24284625//24981863//26404942//27773535//27371828//27773536//22575960
chr12:46662546-46662547(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr12:46662737-46662738(-) m6A 5'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr12:46662777-46662778(-) m6A 5'UTR//exon       24284625//24981863//22575960//22608085
chr12:46663638-46663639(-) m6A 5'UTR//intron       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-100-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
SLC38A1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-100-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-100-3p
Interactor2: SLC38A1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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