Basic Information:

  VIRBase ID:  

HHID00008610

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-100-3p:  MIMAT0004512          ZFYVE21:  NM_001198953     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-100-3p	ZFYVE21
miRBase Accession/Entrez ID	MIMAT0004512	79038
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCVP7TP1//ZF21

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-100-3p	rs1388368183 chr11:122152253    A/G rs530428149 chr11:122152245    C/T rs749039221 chr11:122152247    A/G rs775253529 chr11:122152245    CTA/C rs909526986 chr11:122152248    T/C rs1321972926 chr11:122152258    C/T rs770590792 chr11:122152255    A/G rs773933142 chr11:122152260    T/C rs773933142 chr11:122152260    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZFYVE21	chr14:104185726(+) A-I      intronic chr14:104189052(+) A-I      intronic chr14:104188778(+) A-I      intronic chr14:104188792(+) A-I      intronic chr14:104188893(+) A-I      intronic chr14:104188973(+) A-I      intronic chr14:104185721(+) A-I      intronic chr14:104193483(+) A-I      intronic chr14:104185650(+) A-I      intronic chr14:104185713(+) A-I      intronic chr14:104193492(+) A-I      intronic chr14:104185741(+) A-I      intronic chr14:104193480(+) A-I      intronic chr14:104189097(+) A-I      intronic chr14:104197432(+) A-I      intronic chr14:104188901(+) A-I      intronic chr14:104189035(+) A-I      intronic chr14:104189176(+) A-I      intronic chr14:104189261(+) A-I      intronic chr14:104188818(+) A-I      intronic chr14:104187260(+) A-I      intronic chr14:104188759(+) A-I      intronic chr14:104187183(+) A-I      intronic chr14:104187259(+) A-I      intronic chr14:104188831(+) A-I      intronic chr14:104185780(+) A-I      intronic chr14:104187277(+) A-I      intronic chr14:104188748(+) A-I      intronic chr14:104189101(+) A-I      intronic chr14:104197437(+) A-I      intronic chr14:104188902(+) A-I      intronic chr14:104188821(+) A-I      intronic chr14:104185686(+) A-I      intronic chr14:104188715(+) A-I      intronic chr14:104185494(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZFYVE21	chr14:104197572(+) A-I intron -    21960545 chr14:104197527(+) G-A intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFYVE21	chr14:104191030-104191031(+) m6A exon//intron       - chr14:104199347-104199348(+) m6A CDS//exon       24981863 chr14:104199396-104199397(+) m6A 3'UTR//exon       24981863 chr14:104199411-104199412(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-100-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	ZFYVE21	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-100-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-100-3p
Interactor2: ZFYVE21

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).